Impact of Exon 1 polymorphism in the MBL2 gene on MBL serum levels and infection susceptibility in acute lymphoid leukemia

Impact of Exon 1 polymorphism in the MBL2 gene on MBL serum levels and infection susceptibility in acute lymphoid leukemia

Abstract Polymorphisms in the MBL2 gene exon 1 can decrease serum levels of mannose-binding lectin (MBL), increasing the risk of infection in immunocompromised individuals. This study evaluated the association between the polymorphism in exon 1 of the MBL2 gene, genotypes, serum MBL levels, and infe...

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Bibliographic Details
Main Authors: Leonardo Calheiros de Oliveira, Paulo Henrique Rodrigues de Souza, Anderson Nogueira Barbosa, Luma Silva Mineiro, Gemilson Soares Pontes
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Mannose-binding lectin
Polymorphism
Susceptibility
Acute lymphoid leukemia
Infectious diseases
Online Access:https://doi.org/10.1038/s41598-024-81971-1
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