Nanoarchitectonics of point-of-care diagnostics for sweat biomarkers analysis
Sweat contains numerous vital biomarkers such as metabolites, electrolytes, proteins, nucleic acids and antigens that reflect hydration status, exhaustion, nutrition, and physiological changes. Conventional healthcare diagnosis relies on disease diagnostics in sophisticated centralized laboratories...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2024-12-01
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| Series: | Nano Materials Science |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589965124000102 |
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| author | Xuan Lin Arya Vasanth Aditya Ashok Hoang-Phuong Phan Kevin M. Koo Mohammed A. Amin Yusuf Valentino Kaneti Carlos Salomon Md Shahriar A. Hossain Yusuke Yamauchi Mostafa Kamal Masud |
| author_facet | Xuan Lin Arya Vasanth Aditya Ashok Hoang-Phuong Phan Kevin M. Koo Mohammed A. Amin Yusuf Valentino Kaneti Carlos Salomon Md Shahriar A. Hossain Yusuke Yamauchi Mostafa Kamal Masud |
| author_sort | Xuan Lin |
| collection | DOAJ |
| description | Sweat contains numerous vital biomarkers such as metabolites, electrolytes, proteins, nucleic acids and antigens that reflect hydration status, exhaustion, nutrition, and physiological changes. Conventional healthcare diagnosis relies on disease diagnostics in sophisticated centralized laboratories with invasive sample collection (e.g., chemical analyses, plasma separation via centrifugation, tissue biopsy, etc.). Cutting-edge point-of-care diagnostics for sweat biomarker analysis allow for non-invasive monitoring of physiologically related biomarkers in sweat and real-time health status tracking. Moreover, using advanced nanoarchitectures, including nanostructured platforms and nanoparticles, can enhance the specificity, sensitivity, wearability and widen the sensing modality of sweat biosensors. Herein, we comprehensively review the secretory mechanisms, clinical uses of sweat biomarkers, and the design, principle, and latest technologies of sweat biosensors. With an emphasis on cutting-edge technologies for sweat biomarker analysis, this review chronicles the issues associated with the current sweat biomarkers analysis of sweat biomarkers and provides insights into strategies for enhancing the translation of such biosensors into routine clinical practice. |
| format | Article |
| id | doaj-art-343e583b4e7b4ad4a5ffcf396b0f6aa1 |
| institution | Kabale University |
| issn | 2589-9651 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Nano Materials Science |
| spelling | doaj-art-343e583b4e7b4ad4a5ffcf396b0f6aa12025-01-04T04:56:52ZengKeAi Communications Co., Ltd.Nano Materials Science2589-96512024-12-0166647671Nanoarchitectonics of point-of-care diagnostics for sweat biomarkers analysisXuan Lin0Arya Vasanth1Aditya Ashok2Hoang-Phuong Phan3Kevin M. Koo4Mohammed A. Amin5Yusuf Valentino Kaneti6Carlos Salomon7Md Shahriar A. Hossain8Yusuke Yamauchi9Mostafa Kamal Masud10School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, 4072, AustraliaAustralian Institute of Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD, 4076, AustraliaAustralian Institute of Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD, 4076, AustraliaGraduate School of Biomedical Engineering, The University of New South Wales, Sydney, NSW, 2052, AustraliaThe University of Queensland Centre for Clinical Research (UQCCR), Herston, Queensland, 4029, AustraliaDepartment of Chemistry, College of Science, Taif University, P.O. Box 11099, Taif, 21944, Saudi ArabiaAustralian Institute of Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD, 4076, AustraliaTranslational Extracellular Vesicles in Obstetrics and Gynae-Oncology Group, University of Queensland Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, QLD 4029, AustraliaAustralian Institute of Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD, 4076, Australia; School of Mechanical and Mining Engineering, Faculty of Engineering, Architecture and Information Technology (EAIT), The University of Queensland, Brisbane, QLD, 4072, Australia; Corresponding author. School of Mechanical and Mining Engineering, Faculty of Engineering, Architecture and Information Technology (EAIT), The University of Queensland, Brisbane, QLD, 4072, Australia.Australian Institute of Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD, 4076, Australia; Department of Materials Process Engineering, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Aichi, 464-8603, Japan; Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul 03722, South KoreaAustralian Institute of Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD, 4076, Australia; Corresponding author. Australian Institute of Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD, 4076, Australia.Sweat contains numerous vital biomarkers such as metabolites, electrolytes, proteins, nucleic acids and antigens that reflect hydration status, exhaustion, nutrition, and physiological changes. Conventional healthcare diagnosis relies on disease diagnostics in sophisticated centralized laboratories with invasive sample collection (e.g., chemical analyses, plasma separation via centrifugation, tissue biopsy, etc.). Cutting-edge point-of-care diagnostics for sweat biomarker analysis allow for non-invasive monitoring of physiologically related biomarkers in sweat and real-time health status tracking. Moreover, using advanced nanoarchitectures, including nanostructured platforms and nanoparticles, can enhance the specificity, sensitivity, wearability and widen the sensing modality of sweat biosensors. Herein, we comprehensively review the secretory mechanisms, clinical uses of sweat biomarkers, and the design, principle, and latest technologies of sweat biosensors. With an emphasis on cutting-edge technologies for sweat biomarker analysis, this review chronicles the issues associated with the current sweat biomarkers analysis of sweat biomarkers and provides insights into strategies for enhancing the translation of such biosensors into routine clinical practice.http://www.sciencedirect.com/science/article/pii/S2589965124000102Sweat biomarkerNanoarchitectonicsNanostructuresSweat biosensorPoint-of-care diagnosticsWearable sweat sensor |
| spellingShingle | Xuan Lin Arya Vasanth Aditya Ashok Hoang-Phuong Phan Kevin M. Koo Mohammed A. Amin Yusuf Valentino Kaneti Carlos Salomon Md Shahriar A. Hossain Yusuke Yamauchi Mostafa Kamal Masud Nanoarchitectonics of point-of-care diagnostics for sweat biomarkers analysis Nano Materials Science Sweat biomarker Nanoarchitectonics Nanostructures Sweat biosensor Point-of-care diagnostics Wearable sweat sensor |
| title | Nanoarchitectonics of point-of-care diagnostics for sweat biomarkers analysis |
| title_full | Nanoarchitectonics of point-of-care diagnostics for sweat biomarkers analysis |
| title_fullStr | Nanoarchitectonics of point-of-care diagnostics for sweat biomarkers analysis |
| title_full_unstemmed | Nanoarchitectonics of point-of-care diagnostics for sweat biomarkers analysis |
| title_short | Nanoarchitectonics of point-of-care diagnostics for sweat biomarkers analysis |
| title_sort | nanoarchitectonics of point of care diagnostics for sweat biomarkers analysis |
| topic | Sweat biomarker Nanoarchitectonics Nanostructures Sweat biosensor Point-of-care diagnostics Wearable sweat sensor |
| url | http://www.sciencedirect.com/science/article/pii/S2589965124000102 |
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