Association between maternal smoking during pregnancy and smoking behaviors in adult offspring
BackgroundMaternal smoking during pregnancy (MSP) is associated with offspring smoking. However, there is still scant evidence to support the association between MSP and smoking behaviors in adult offspring.MethodsThis is a prospective cohort study based on the UK Biobank. Maternal smoking around bi...
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2025.1505418/full |
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| author | Lin Yang Jing Li Jing Li Yinzi Chen Yanling Wei Congying Song Jingwen Zhang Liang Dai Yu Shi Zuying Xiong Ying Shan Xiaoyan Huang Xiaoyan Huang |
| author_facet | Lin Yang Jing Li Jing Li Yinzi Chen Yanling Wei Congying Song Jingwen Zhang Liang Dai Yu Shi Zuying Xiong Ying Shan Xiaoyan Huang Xiaoyan Huang |
| author_sort | Lin Yang |
| collection | DOAJ |
| description | BackgroundMaternal smoking during pregnancy (MSP) is associated with offspring smoking. However, there is still scant evidence to support the association between MSP and smoking behaviors in adult offspring.MethodsThis is a prospective cohort study based on the UK Biobank. Maternal smoking around birth was reported by the offspring through a questionnaire. Participants with unknown maternal smoking status were classified as having missing values. Logistic regression, linear regression and negative binomial regression models were used to estimate the associations of exposure to maternal smoking around birth with four outcomes of offspring smoking behaviors, including smoking status, age started smoking, pack years of smoking, and number of unsuccessful stop-smoking attempts.ResultsWe included 156,604, 101,204, 96,466, and 70,308 participants in the analyses of smoking status, age started smoking, pack years of smoking, and number of unsuccessful stop-smoking attempts, respectively. After adjusted for potential confounders, MSP demonstrated significant associations with offspring smoking (OR: 1.08 [95% CI: 1.07, 1.10]), age started smoking (beta per year: −0.83 [95% CI: −0.89, −0.77]), pack years of smoking (beta per pack-year: 3.51 [95% CI: 3.28, 3.74]) and number of unsuccessful stop-smoking attempts (IRR: 1.11 [95% CI 1.09, 1.13]). Subgroup analysis showed the excessive risks for smoking status and age started smoking in females, pack years of smoking in males, and for number of unsuccessful stop-smoking attempts in the non-breastfeeding group.ConclusionThe unfavorable effects of maternal smoking around birth might reach at least up to offspring’s middle even older age. Smoking cessation before pregnancy should be encouraged to prevent the transmission to the next generation. |
| format | Article |
| id | doaj-art-3428d906b51a45a5a59bd0554557f38a |
| institution | Kabale University |
| issn | 2296-2565 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj-art-3428d906b51a45a5a59bd0554557f38a2025-08-20T03:44:28ZengFrontiers Media S.A.Frontiers in Public Health2296-25652025-03-011310.3389/fpubh.2025.15054181505418Association between maternal smoking during pregnancy and smoking behaviors in adult offspringLin Yang0Jing Li1Jing Li2Yinzi Chen3Yanling Wei4Congying Song5Jingwen Zhang6Liang Dai7Yu Shi8Zuying Xiong9Ying Shan10Xiaoyan Huang11Xiaoyan Huang12Health Management Center, Peking University Shenzhen Hospital, Peking University, Shenzhen, ChinaRenal Division, Peking University Shenzhen Hospital, Peking University, Shenzhen, ChinaClinical Research Academy, Peking University Shenzhen Hospital, Peking University, Shenzhen, ChinaSchool of Public Health, Fudan University, Shanghai, ChinaClinical Research Academy, Peking University Shenzhen Hospital, Peking University, Shenzhen, ChinaClinical Research Academy, Peking University Shenzhen Hospital, Peking University, Shenzhen, ChinaRenal Division, Peking University Shenzhen Hospital, Peking University, Shenzhen, ChinaClinical Research Academy, Peking University Shenzhen Hospital, Peking University, Shenzhen, ChinaDepartment of Ultrasound, Peking University Shenzhen Hospital, Peking University, Shenzhen, ChinaRenal Division, Peking University Shenzhen Hospital, Peking University, Shenzhen, ChinaClinical Research Academy, Peking University Shenzhen Hospital, Peking University, Shenzhen, ChinaRenal Division, Peking University Shenzhen Hospital, Peking University, Shenzhen, ChinaClinical Research Academy, Peking University Shenzhen Hospital, Peking University, Shenzhen, ChinaBackgroundMaternal smoking during pregnancy (MSP) is associated with offspring smoking. However, there is still scant evidence to support the association between MSP and smoking behaviors in adult offspring.MethodsThis is a prospective cohort study based on the UK Biobank. Maternal smoking around birth was reported by the offspring through a questionnaire. Participants with unknown maternal smoking status were classified as having missing values. Logistic regression, linear regression and negative binomial regression models were used to estimate the associations of exposure to maternal smoking around birth with four outcomes of offspring smoking behaviors, including smoking status, age started smoking, pack years of smoking, and number of unsuccessful stop-smoking attempts.ResultsWe included 156,604, 101,204, 96,466, and 70,308 participants in the analyses of smoking status, age started smoking, pack years of smoking, and number of unsuccessful stop-smoking attempts, respectively. After adjusted for potential confounders, MSP demonstrated significant associations with offspring smoking (OR: 1.08 [95% CI: 1.07, 1.10]), age started smoking (beta per year: −0.83 [95% CI: −0.89, −0.77]), pack years of smoking (beta per pack-year: 3.51 [95% CI: 3.28, 3.74]) and number of unsuccessful stop-smoking attempts (IRR: 1.11 [95% CI 1.09, 1.13]). Subgroup analysis showed the excessive risks for smoking status and age started smoking in females, pack years of smoking in males, and for number of unsuccessful stop-smoking attempts in the non-breastfeeding group.ConclusionThe unfavorable effects of maternal smoking around birth might reach at least up to offspring’s middle even older age. Smoking cessation before pregnancy should be encouraged to prevent the transmission to the next generation.https://www.frontiersin.org/articles/10.3389/fpubh.2025.1505418/fullmaternal smokingpregnancyoffspringsmokingUK Biobank |
| spellingShingle | Lin Yang Jing Li Jing Li Yinzi Chen Yanling Wei Congying Song Jingwen Zhang Liang Dai Yu Shi Zuying Xiong Ying Shan Xiaoyan Huang Xiaoyan Huang Association between maternal smoking during pregnancy and smoking behaviors in adult offspring Frontiers in Public Health maternal smoking pregnancy offspring smoking UK Biobank |
| title | Association between maternal smoking during pregnancy and smoking behaviors in adult offspring |
| title_full | Association between maternal smoking during pregnancy and smoking behaviors in adult offspring |
| title_fullStr | Association between maternal smoking during pregnancy and smoking behaviors in adult offspring |
| title_full_unstemmed | Association between maternal smoking during pregnancy and smoking behaviors in adult offspring |
| title_short | Association between maternal smoking during pregnancy and smoking behaviors in adult offspring |
| title_sort | association between maternal smoking during pregnancy and smoking behaviors in adult offspring |
| topic | maternal smoking pregnancy offspring smoking UK Biobank |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2025.1505418/full |
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