Computational epitope-based vaccine design with bioinformatics approach; a review
The significance of vaccine development has gained heightened importance in light of the COVID-19 pandemic. In such critical circumstances, global citizens anticipate researchers in this field to swiftly identify a vaccine candidate to combat the pandemic's root cause. It is widely recognized t...
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| Language: | English |
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Elsevier
2025-01-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844025000945 |
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| author | Esmaeil Roohparvar Basmenj Susan Radman Pajhouh Afsane Ebrahimi Fallah Rafe naijian Elmira Rahimi Hossein Atighy Shadan Ghiabi Shamim Ghiabi |
| author_facet | Esmaeil Roohparvar Basmenj Susan Radman Pajhouh Afsane Ebrahimi Fallah Rafe naijian Elmira Rahimi Hossein Atighy Shadan Ghiabi Shamim Ghiabi |
| author_sort | Esmaeil Roohparvar Basmenj |
| collection | DOAJ |
| description | The significance of vaccine development has gained heightened importance in light of the COVID-19 pandemic. In such critical circumstances, global citizens anticipate researchers in this field to swiftly identify a vaccine candidate to combat the pandemic's root cause. It is widely recognized that the vaccine design process is traditionally both time-consuming and costly. However, a specialized subfield within bioinformatics, known as ''multi-epitope vaccine design'' or ''reverse vaccinology,'' has significantly decreased the time and costs of the vaccine design process. The methodology reverses itself in this subfield and finds a potential vaccine candidate by analyzing the pathogen's genome. Leveraging the tools available in this domain, we strive to pinpoint the most suitable antigen for crafting a vaccine against our target. Once the optimal antigen is identified, the next step involves uncovering epitopes within this antigen. The immune system recognizes particular areas of an antigen as epitopes. By characterizing these crucial segments, we gain the opportunity to design a vaccine centered around these epitopes. Subsequently, after identifying and assembling the vital epitopes with the assistance of linkers and adjuvants, our vaccine candidate can be formulated. Finally, employing computational techniques, we can thoroughly evaluate the designed vaccine. This review article comprehensively covers the entire multi-epitope vaccine development process, starting from obtaining the pathogen's genome to identifying the relevant vaccine candidate and concluding with an evaluation. Furthermore, we will delve into the essential tools needed at each stage, comparing and introducing them. |
| format | Article |
| id | doaj-art-33f7a7ba4b9247e98281e7070117556c |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-33f7a7ba4b9247e98281e7070117556c2025-01-17T04:51:57ZengElsevierHeliyon2405-84402025-01-01111e41714Computational epitope-based vaccine design with bioinformatics approach; a reviewEsmaeil Roohparvar Basmenj0Susan Radman Pajhouh1Afsane Ebrahimi Fallah2Rafe naijian3Elmira Rahimi4Hossein Atighy5Shadan Ghiabi6Shamim Ghiabi7Biophysics Department, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran; Corresponding author.Faculty of Agricultural Sciences, Shahed University, Tehran, IranFaculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, IranStudent research committee, faculty of pharmacy, Mazandaran University of Medical Sciences, Sari, IranDepartment of Biology, Central Tehran Branch, Islamic Azad University, Tehran, IranSchool of Pharmacy, Centro Escolar University, Manila, PhilippinesFaculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, IranTehran Azad University of Medical Sciences, Faculty of Pharmaceutical Sciences, IranThe significance of vaccine development has gained heightened importance in light of the COVID-19 pandemic. In such critical circumstances, global citizens anticipate researchers in this field to swiftly identify a vaccine candidate to combat the pandemic's root cause. It is widely recognized that the vaccine design process is traditionally both time-consuming and costly. However, a specialized subfield within bioinformatics, known as ''multi-epitope vaccine design'' or ''reverse vaccinology,'' has significantly decreased the time and costs of the vaccine design process. The methodology reverses itself in this subfield and finds a potential vaccine candidate by analyzing the pathogen's genome. Leveraging the tools available in this domain, we strive to pinpoint the most suitable antigen for crafting a vaccine against our target. Once the optimal antigen is identified, the next step involves uncovering epitopes within this antigen. The immune system recognizes particular areas of an antigen as epitopes. By characterizing these crucial segments, we gain the opportunity to design a vaccine centered around these epitopes. Subsequently, after identifying and assembling the vital epitopes with the assistance of linkers and adjuvants, our vaccine candidate can be formulated. Finally, employing computational techniques, we can thoroughly evaluate the designed vaccine. This review article comprehensively covers the entire multi-epitope vaccine development process, starting from obtaining the pathogen's genome to identifying the relevant vaccine candidate and concluding with an evaluation. Furthermore, we will delve into the essential tools needed at each stage, comparing and introducing them.http://www.sciencedirect.com/science/article/pii/S2405844025000945Vaccine designReverse vaccinologyMulti epitope vaccineBioinformaticsImmunoinformatics |
| spellingShingle | Esmaeil Roohparvar Basmenj Susan Radman Pajhouh Afsane Ebrahimi Fallah Rafe naijian Elmira Rahimi Hossein Atighy Shadan Ghiabi Shamim Ghiabi Computational epitope-based vaccine design with bioinformatics approach; a review Heliyon Vaccine design Reverse vaccinology Multi epitope vaccine Bioinformatics Immunoinformatics |
| title | Computational epitope-based vaccine design with bioinformatics approach; a review |
| title_full | Computational epitope-based vaccine design with bioinformatics approach; a review |
| title_fullStr | Computational epitope-based vaccine design with bioinformatics approach; a review |
| title_full_unstemmed | Computational epitope-based vaccine design with bioinformatics approach; a review |
| title_short | Computational epitope-based vaccine design with bioinformatics approach; a review |
| title_sort | computational epitope based vaccine design with bioinformatics approach a review |
| topic | Vaccine design Reverse vaccinology Multi epitope vaccine Bioinformatics Immunoinformatics |
| url | http://www.sciencedirect.com/science/article/pii/S2405844025000945 |
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