Hippocampal volumes in UK Biobank are associated with APOE only in older adults
Abstract INTRODUCTION The hippocampus atrophies with age and is implicated in neurodegenerative disorders including Alzheimer's disease (AD). We examined the interplay between age and apolipoprotein E (APOE) genotype on total hippocampal volume. METHODS Using neuroimaging data from 37,463 UK Bi...
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Wiley
2024-10-01
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| Series: | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
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| Online Access: | https://doi.org/10.1002/dad2.70024 |
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| author | Ariya Chaloemtoem Vera Thornton Yoonhoo Chang Andrey P. Anokhin Michaël E. Belloy Janine Bijsterbosch Brian A. Gordon Sarah M. Hartz Laura J. Bierut |
| author_facet | Ariya Chaloemtoem Vera Thornton Yoonhoo Chang Andrey P. Anokhin Michaël E. Belloy Janine Bijsterbosch Brian A. Gordon Sarah M. Hartz Laura J. Bierut |
| author_sort | Ariya Chaloemtoem |
| collection | DOAJ |
| description | Abstract INTRODUCTION The hippocampus atrophies with age and is implicated in neurodegenerative disorders including Alzheimer's disease (AD). We examined the interplay between age and apolipoprotein E (APOE) genotype on total hippocampal volume. METHODS Using neuroimaging data from 37,463 UK Biobank participants, we applied linear regression to quantify the association of age and APOE with hippocampal volume and identified the age when volumes of ε2/ε3, ε3/ε4, and ε4/ε4 carriers significantly deviated from ε3/ε3 using generalized additive modeling. RESULTS Total hippocampal volume declined with age, with significant differences by APOE genotype emerging after age 60. ε3/ε4 and ε4/ε4 carriers displayed reduced volumes from ages 69 and 61, respectively, while ε2/ε3 showed delayed decline starting at the age of 76. DISCUSSION The association of APOE and hippocampal volume is age‐dependent, with differences in volumes of ε4/ε4 carriers detected as early as age 61. This work underscores the importance of APOE genotype in determining when to begin screening for AD. Highlights Apolipoprotein E (APOE) genotype shows an age‐dependent association with total hippocampal volume. No association between APOE and total hippocampal volume was detected before age 60. Accelerated decline was observed in ε4/ε4 carriers at age 61 and ε3/ε4 at age 69. Delayed decline was evident in ε2/ε3 carriers starting at age 76. |
| format | Article |
| id | doaj-art-33e67a190a7b4d7eb827099a560454c7 |
| institution | Kabale University |
| issn | 2352-8729 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| spelling | doaj-art-33e67a190a7b4d7eb827099a560454c72024-12-27T13:08:30ZengWileyAlzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring2352-87292024-10-01164n/an/a10.1002/dad2.70024Hippocampal volumes in UK Biobank are associated with APOE only in older adultsAriya Chaloemtoem0Vera Thornton1Yoonhoo Chang2Andrey P. Anokhin3Michaël E. Belloy4Janine Bijsterbosch5Brian A. Gordon6Sarah M. Hartz7Laura J. Bierut8Department of Psychiatry Washington University School of Medicine St. Louis Missouri USADepartment of Psychiatry Washington University School of Medicine St. Louis Missouri USADepartment of Psychiatry Washington University School of Medicine St. Louis Missouri USADepartment of Psychiatry Washington University School of Medicine St. Louis Missouri USANeuroGenomics and Informatics Center Washington University School of Medicine St. Louis Missouri USADepartment of Radiology Washington University School of Medicine St. Louis Missouri USANeuroGenomics and Informatics Center Washington University School of Medicine St. Louis Missouri USADepartment of Psychiatry Washington University School of Medicine St. Louis Missouri USADepartment of Psychiatry Washington University School of Medicine St. Louis Missouri USAAbstract INTRODUCTION The hippocampus atrophies with age and is implicated in neurodegenerative disorders including Alzheimer's disease (AD). We examined the interplay between age and apolipoprotein E (APOE) genotype on total hippocampal volume. METHODS Using neuroimaging data from 37,463 UK Biobank participants, we applied linear regression to quantify the association of age and APOE with hippocampal volume and identified the age when volumes of ε2/ε3, ε3/ε4, and ε4/ε4 carriers significantly deviated from ε3/ε3 using generalized additive modeling. RESULTS Total hippocampal volume declined with age, with significant differences by APOE genotype emerging after age 60. ε3/ε4 and ε4/ε4 carriers displayed reduced volumes from ages 69 and 61, respectively, while ε2/ε3 showed delayed decline starting at the age of 76. DISCUSSION The association of APOE and hippocampal volume is age‐dependent, with differences in volumes of ε4/ε4 carriers detected as early as age 61. This work underscores the importance of APOE genotype in determining when to begin screening for AD. Highlights Apolipoprotein E (APOE) genotype shows an age‐dependent association with total hippocampal volume. No association between APOE and total hippocampal volume was detected before age 60. Accelerated decline was observed in ε4/ε4 carriers at age 61 and ε3/ε4 at age 69. Delayed decline was evident in ε2/ε3 carriers starting at age 76.https://doi.org/10.1002/dad2.70024ageAlzheimer's diseaseapolipoprotein EhippocampusneurodegenerationUK Biobank |
| spellingShingle | Ariya Chaloemtoem Vera Thornton Yoonhoo Chang Andrey P. Anokhin Michaël E. Belloy Janine Bijsterbosch Brian A. Gordon Sarah M. Hartz Laura J. Bierut Hippocampal volumes in UK Biobank are associated with APOE only in older adults Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring age Alzheimer's disease apolipoprotein E hippocampus neurodegeneration UK Biobank |
| title | Hippocampal volumes in UK Biobank are associated with APOE only in older adults |
| title_full | Hippocampal volumes in UK Biobank are associated with APOE only in older adults |
| title_fullStr | Hippocampal volumes in UK Biobank are associated with APOE only in older adults |
| title_full_unstemmed | Hippocampal volumes in UK Biobank are associated with APOE only in older adults |
| title_short | Hippocampal volumes in UK Biobank are associated with APOE only in older adults |
| title_sort | hippocampal volumes in uk biobank are associated with apoe only in older adults |
| topic | age Alzheimer's disease apolipoprotein E hippocampus neurodegeneration UK Biobank |
| url | https://doi.org/10.1002/dad2.70024 |
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