Isoleucine gate blocks K+ conduction in C-type inactivation

Isoleucine gate blocks K+ conduction in C-type inactivation

Many voltage-gated potassium (Kv) channels display a time-dependent phenomenon called C-type inactivation, whereby prolonged activation by voltage leads to the inhibition of ionic conduction, a process that involves a conformational change at the selectivity filter toward a non-conductive state. Rec...

Full description

Saved in:
Bibliographic Details
Main Authors: Werner Treptow, Yichen Liu, Carlos AZ Bassetto, Bernardo I Pinto, Joao Antonio Alves Nunes, Ramon Mendoza Uriarte, Christophe J Chipot, Francisco Bezanilla, Benoit Roux
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-11-01
Series:eLife
Subjects:
ion conduction
membrane
free energy
conformation
electrophysioloby
molecular dynamics
Online Access:https://elifesciences.org/articles/97696
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://elifesciences.org/articles/97696

Similar Items