Proteolysis targeting chimera (PROTAC)-driven antibody internalization of oncogenic cell surface receptors

Proteolysis targeting chimera (PROTAC)-driven antibody internalization of oncogenic cell surface receptors

Abstract Antibody-drug conjugates (ADCs) are increasingly used in clinic for multiple indications and may improve upon the activity of parental antibodies by delivering cytotoxic payloads into target cells. This activity is predicated upon internalization to release the cytotoxic payloads intracellu...

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Bibliographic Details
Main Authors: Ezequiel J. Tolosa, Lin Yang, Jennifer Ayers-Ringler, Shinichiro Suzuki, Jayapal Reddy Mallareddy, Janet Schaefer-Klein, Mitesh Borad, Farhad Kosari, Amarnath Natarajan, Aaron S. Mansfield
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-024-07439-0
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