Extensive methylation analysis of circulating tumor DNA in plasma of patients with gastric cancer

Extensive methylation analysis of circulating tumor DNA in plasma of patients with gastric cancer

Abstract DNA methylation is known to be involved in tumor progression. This is the first study to perform an extensive methylation analysis of plasma circulating tumor DNA (ctDNA) using targeted bisulfite sequencing in gastric cancer (GC) patients to evaluate the usefulness of ctDNA methylation as a...

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Bibliographic Details
Main Authors: Shinnosuke Nagano, Yukinori Kurokawa, Takaomi Hagi, Ryo Yoshioka, Tsuyoshi Takahashi, Takuro Saito, Kazuyoshi Yamamoto, Kota Momose, Kotaro Yamashita, Koji Tanaka, Tomoki Makino, Kiyokazu Nakajima, Hidetoshi Eguchi, Yuichiro Doki
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Scientific Reports
Subjects:
DNA methylation
Gastric cancer
Target bisulfite sequencing
Biomarker
Liquid biopsy
Online Access:https://doi.org/10.1038/s41598-024-79252-y
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