The Neurological Impact of Leprosy: Manifestations and Treatment Approaches
Background and Objectives: Leprosy primarily affects peripheral nerves, leading to significant neurological complications such as polyneuritis, mononeurosis, and autonomic dysfunction, which contribute to severe disabilities and impaired quality of life for patients. This scoping review aims to inve...
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MDPI AG
2024-11-01
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| Series: | Neurology International |
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| Online Access: | https://www.mdpi.com/2035-8377/16/6/111 |
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| author | Andrea Calderone Maria Catena Aloisi Carmela Casella Salvatore Fiannacca Bruno Cosenza Angelo Quartarone Rocco Salvatore Calabrò |
| author_facet | Andrea Calderone Maria Catena Aloisi Carmela Casella Salvatore Fiannacca Bruno Cosenza Angelo Quartarone Rocco Salvatore Calabrò |
| author_sort | Andrea Calderone |
| collection | DOAJ |
| description | Background and Objectives: Leprosy primarily affects peripheral nerves, leading to significant neurological complications such as polyneuritis, mononeurosis, and autonomic dysfunction, which contribute to severe disabilities and impaired quality of life for patients. This scoping review aims to investigate the neurological manifestations and main treatments of leprosy patients. Materials and Methods: Studies were identified from an online search of PubMed, Web of Science, Cochrane Library, Embase, and Scopus databases. This review has been registered on OSF (n) PQBYH. Results: Neurological complications of leprosy, such as neuropathy and paralysis, necessitate accurate diagnosis and treatment, as immunological reactions can exacerbate nerve damage. Various studies highlight the effectiveness of personalized therapies, such as corticosteroids, multi-drug therapy (MDT), and surgical interventions, in improving symptoms and neurological function in leprosy patients. Conclusions: Managing neurological complications of leprosy necessitates careful diagnosis and treatment, as many patients experience unresolved peripheral neuropathy despite multidrug therapy. Future research should focus on improving diagnostic tools, exploring the link between neuropathic pain and psychological issues, and developing effective vaccines and treatments to enhance patient outcomes. |
| format | Article |
| id | doaj-art-33c2039843f149d7be2ef904c83c5778 |
| institution | Kabale University |
| issn | 2035-8377 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Neurology International |
| spelling | doaj-art-33c2039843f149d7be2ef904c83c57782024-12-27T14:43:50ZengMDPI AGNeurology International2035-83772024-11-011661492150810.3390/neurolint16060111The Neurological Impact of Leprosy: Manifestations and Treatment ApproachesAndrea Calderone0Maria Catena Aloisi1Carmela Casella2Salvatore Fiannacca3Bruno Cosenza4Angelo Quartarone5Rocco Salvatore Calabrò6Department of Clinical and Experimental Medicine, University of Messina, Piazza Pugliatti, 1, 98122 Messina, ItalyIRCCS Centro Neurolesi Bonino-Pulejo, S.S. 113 Via Palermo, C.da Casazza, 98124 Messina, ItalyStroke Unit, University of Messina, Piazza Pugliatti, 1, 98122 Messina, ItalyIRCCS Centro Neurolesi Bonino-Pulejo, S.S. 113 Via Palermo, C.da Casazza, 98124 Messina, ItalyIRCCS Centro Neurolesi Bonino-Pulejo, S.S. 113 Via Palermo, C.da Casazza, 98124 Messina, ItalyIRCCS Centro Neurolesi Bonino-Pulejo, S.S. 113 Via Palermo, C.da Casazza, 98124 Messina, ItalyIRCCS Centro Neurolesi Bonino-Pulejo, S.S. 113 Via Palermo, C.da Casazza, 98124 Messina, ItalyBackground and Objectives: Leprosy primarily affects peripheral nerves, leading to significant neurological complications such as polyneuritis, mononeurosis, and autonomic dysfunction, which contribute to severe disabilities and impaired quality of life for patients. This scoping review aims to investigate the neurological manifestations and main treatments of leprosy patients. Materials and Methods: Studies were identified from an online search of PubMed, Web of Science, Cochrane Library, Embase, and Scopus databases. This review has been registered on OSF (n) PQBYH. Results: Neurological complications of leprosy, such as neuropathy and paralysis, necessitate accurate diagnosis and treatment, as immunological reactions can exacerbate nerve damage. Various studies highlight the effectiveness of personalized therapies, such as corticosteroids, multi-drug therapy (MDT), and surgical interventions, in improving symptoms and neurological function in leprosy patients. Conclusions: Managing neurological complications of leprosy necessitates careful diagnosis and treatment, as many patients experience unresolved peripheral neuropathy despite multidrug therapy. Future research should focus on improving diagnostic tools, exploring the link between neuropathic pain and psychological issues, and developing effective vaccines and treatments to enhance patient outcomes.https://www.mdpi.com/2035-8377/16/6/111leprosyneurological complicationsneuropathytreatments |
| spellingShingle | Andrea Calderone Maria Catena Aloisi Carmela Casella Salvatore Fiannacca Bruno Cosenza Angelo Quartarone Rocco Salvatore Calabrò The Neurological Impact of Leprosy: Manifestations and Treatment Approaches Neurology International leprosy neurological complications neuropathy treatments |
| title | The Neurological Impact of Leprosy: Manifestations and Treatment Approaches |
| title_full | The Neurological Impact of Leprosy: Manifestations and Treatment Approaches |
| title_fullStr | The Neurological Impact of Leprosy: Manifestations and Treatment Approaches |
| title_full_unstemmed | The Neurological Impact of Leprosy: Manifestations and Treatment Approaches |
| title_short | The Neurological Impact of Leprosy: Manifestations and Treatment Approaches |
| title_sort | neurological impact of leprosy manifestations and treatment approaches |
| topic | leprosy neurological complications neuropathy treatments |
| url | https://www.mdpi.com/2035-8377/16/6/111 |
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