Human induced pluripotent stem cell line XXMUFAi001-A generated from a patient harboring KCNH2 mutation (c. 2690 A>C)
Long QT syndrome type 2 (LQT2), caused by mutations in the KCNH2 gene, is an inherited ion channel disorder associated with sudden death in adolescents. In this study, we generated a patient-specific induced pluripotent stem cell (iPSC) line XXMUFAi001-A using non-integrative Sendai reprogramming te...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Stem Cell Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1873506124003337 |
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| _version_ | 1841543967650349056 |
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| author | Xiaolei Li Junbiao Zhang Xiaofeng Wang Dawei Pu Zhenling Zhang Yifang Niu Shuai Zhang Zhenping Fan Yuxuan Li Peicheng Li Hui Liu Fenghua Lv Yongchun Zhang Ya’nan Li |
| author_facet | Xiaolei Li Junbiao Zhang Xiaofeng Wang Dawei Pu Zhenling Zhang Yifang Niu Shuai Zhang Zhenping Fan Yuxuan Li Peicheng Li Hui Liu Fenghua Lv Yongchun Zhang Ya’nan Li |
| author_sort | Xiaolei Li |
| collection | DOAJ |
| description | Long QT syndrome type 2 (LQT2), caused by mutations in the KCNH2 gene, is an inherited ion channel disorder associated with sudden death in adolescents. In this study, we generated a patient-specific induced pluripotent stem cell (iPSC) line XXMUFAi001-A using non-integrative Sendai reprogramming technology from an individual carrying a heterozygous point mutation (c.2690 A>C) in KCNH2. XXMUFAi001-A cell line exhibited expression of pluripotency markers and demonstrated teratoma formation capability in vivo, as well as the potential to differentiate into all three germ layers. The establishment of XXMUFAi001-A is crucial for investigating the pathogenesis and drug screening of LQT2. |
| format | Article |
| id | doaj-art-33645525b9eb43668557099c270db70c |
| institution | Kabale University |
| issn | 1873-5061 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Stem Cell Research |
| spelling | doaj-art-33645525b9eb43668557099c270db70c2025-01-13T04:18:42ZengElsevierStem Cell Research1873-50612025-02-0182103635Human induced pluripotent stem cell line XXMUFAi001-A generated from a patient harboring KCNH2 mutation (c. 2690 A>C)Xiaolei Li0Junbiao Zhang1Xiaofeng Wang2Dawei Pu3Zhenling Zhang4Yifang Niu5Shuai Zhang6Zhenping Fan7Yuxuan Li8Peicheng Li9Hui Liu10Fenghua Lv11Yongchun Zhang12Ya’nan Li13Department of Cardiology, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang Medical University, Weihui 453100, ChinaDepartment of Cardiology, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang Medical University, Weihui 453100, ChinaDepartment of Cardiology, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang Medical University, Weihui 453100, ChinaDepartment of Cardiology, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang Medical University, Weihui 453100, ChinaDepartment of Cardiology, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang Medical University, Weihui 453100, ChinaDepartment of Cardiology, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang Medical University, Weihui 453100, ChinaDepartment of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, ChinaDepartment of Cardiology, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang Medical University, Weihui 453100, ChinaDepartment of Cardiology, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang Medical University, Weihui 453100, ChinaDepartment of Cardiology, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang Medical University, Weihui 453100, ChinaDepartment of Cardiology, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang Medical University, Weihui 453100, ChinaDepartment of Cardiology, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang Medical University, Weihui 453100, ChinaDepartment of Cardiology, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang Medical University, Weihui 453100, ChinaDepartment of Cardiology, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang Medical University, Weihui 453100, China; Corresponding author at: The First Affiliated Hospital of Xinxiang Medical University, Xinxiang Medical University, Jiankang Road No. 88, Weihui 453100, China.Long QT syndrome type 2 (LQT2), caused by mutations in the KCNH2 gene, is an inherited ion channel disorder associated with sudden death in adolescents. In this study, we generated a patient-specific induced pluripotent stem cell (iPSC) line XXMUFAi001-A using non-integrative Sendai reprogramming technology from an individual carrying a heterozygous point mutation (c.2690 A>C) in KCNH2. XXMUFAi001-A cell line exhibited expression of pluripotency markers and demonstrated teratoma formation capability in vivo, as well as the potential to differentiate into all three germ layers. The establishment of XXMUFAi001-A is crucial for investigating the pathogenesis and drug screening of LQT2.http://www.sciencedirect.com/science/article/pii/S1873506124003337 |
| spellingShingle | Xiaolei Li Junbiao Zhang Xiaofeng Wang Dawei Pu Zhenling Zhang Yifang Niu Shuai Zhang Zhenping Fan Yuxuan Li Peicheng Li Hui Liu Fenghua Lv Yongchun Zhang Ya’nan Li Human induced pluripotent stem cell line XXMUFAi001-A generated from a patient harboring KCNH2 mutation (c. 2690 A>C) Stem Cell Research |
| title | Human induced pluripotent stem cell line XXMUFAi001-A generated from a patient harboring KCNH2 mutation (c. 2690 A>C) |
| title_full | Human induced pluripotent stem cell line XXMUFAi001-A generated from a patient harboring KCNH2 mutation (c. 2690 A>C) |
| title_fullStr | Human induced pluripotent stem cell line XXMUFAi001-A generated from a patient harboring KCNH2 mutation (c. 2690 A>C) |
| title_full_unstemmed | Human induced pluripotent stem cell line XXMUFAi001-A generated from a patient harboring KCNH2 mutation (c. 2690 A>C) |
| title_short | Human induced pluripotent stem cell line XXMUFAi001-A generated from a patient harboring KCNH2 mutation (c. 2690 A>C) |
| title_sort | human induced pluripotent stem cell line xxmufai001 a generated from a patient harboring kcnh2 mutation c 2690 a c |
| url | http://www.sciencedirect.com/science/article/pii/S1873506124003337 |
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