Morinda officinalis oligosaccharides alleviate chronic unpredictable mild stress-induced depression through the BDNF/TrkB/CREB pathway and symptoms of sexual dysfunction in mice
BackgroundIn recent years, depression has become a global public health concern, and one of the common concomitant symptoms are diminished sexual motivation and impaired sexual performance. The aim of this study was to investigate the potential effects of Morinda officinalis oligosaccharides (MOO) o...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2024.1509543/full |
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| author | Mengjie He Mengying Hu Tingqiao Wang Zeping Zuo Hongkai Li Zhiwei Zhao Yunwen Hao Xueling Dai Jianfang Wang Yaxuan Sun |
| author_facet | Mengjie He Mengying Hu Tingqiao Wang Zeping Zuo Hongkai Li Zhiwei Zhao Yunwen Hao Xueling Dai Jianfang Wang Yaxuan Sun |
| author_sort | Mengjie He |
| collection | DOAJ |
| description | BackgroundIn recent years, depression has become a global public health concern, and one of the common concomitant symptoms are diminished sexual motivation and impaired sexual performance. The aim of this study was to investigate the potential effects of Morinda officinalis oligosaccharides (MOO) on depression and its concomitant symptom, sexual dysfunction.MethodsChronic unpredictable mild stress (CUMS)-induced depression model was constructed, and the effects of MOO on depression and sexual abilities were evaluated.ResultsThe results revealed that MOO was able to alleviate CUMS-induced depression-like behavior in mice, to inhibit hippocampal neuron apoptosis, to reverse monoamine neurotransmitter imbalance, increase Brain-derived neurotrophic factor (BDNF) expression levels in the hippocampus, to modulate the composition and distribution of gut microbiota, and to increase the abundance of probiotics after continuous gavage of MOO for 28 days. MOO further confirmed that sexual dysfunction is closely related to the development of depression by improving the lack of sexual motivation and low sexual performance in CUMS-induced depressed mice, modulating the disruption of sex hormone secretion in serum, and alleviating sperm morphology and functional defects in the epididymis.ConclusionThese findings on MOO provide a basis for exploring its antidepressant mechanism, its use to improve hypogonadotropic symptoms, and for future development of new antidepressant drug to improves hypogonadotropic symptoms. |
| format | Article |
| id | doaj-art-3325e558956d421c810510e76cb56f63 |
| institution | Kabale University |
| issn | 1662-453X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj-art-3325e558956d421c810510e76cb56f632025-01-08T06:11:41ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2025-01-011810.3389/fnins.2024.15095431509543Morinda officinalis oligosaccharides alleviate chronic unpredictable mild stress-induced depression through the BDNF/TrkB/CREB pathway and symptoms of sexual dysfunction in miceMengjie He0Mengying Hu1Tingqiao Wang2Zeping Zuo3Hongkai Li4Zhiwei Zhao5Yunwen Hao6Xueling Dai7Jianfang Wang8Yaxuan Sun9Beijing Key Laboratory of Bioactive Substances and Functional Food, Beijing Union University, Beijing, ChinaSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, ChinaBeijing Key Laboratory of Bioactive Substances and Functional Food, Beijing Union University, Beijing, ChinaBeijing Tongrentang Company Limited, Beijing, China, ChinaBeijing Tongrentang Company Limited, Beijing, China, ChinaBeijing Tongrentang Company Limited, Beijing, China, ChinaFaculty of Land and Food Systems, University of British Columbia, Vancouver, BC, CanadaBeijing Key Laboratory of Bioactive Substances and Functional Food, Beijing Union University, Beijing, ChinaDongfang Hospital, Beijing University of Chinese Medicine, Beijing, ChinaBeijing Key Laboratory of Bioactive Substances and Functional Food, Beijing Union University, Beijing, ChinaBackgroundIn recent years, depression has become a global public health concern, and one of the common concomitant symptoms are diminished sexual motivation and impaired sexual performance. The aim of this study was to investigate the potential effects of Morinda officinalis oligosaccharides (MOO) on depression and its concomitant symptom, sexual dysfunction.MethodsChronic unpredictable mild stress (CUMS)-induced depression model was constructed, and the effects of MOO on depression and sexual abilities were evaluated.ResultsThe results revealed that MOO was able to alleviate CUMS-induced depression-like behavior in mice, to inhibit hippocampal neuron apoptosis, to reverse monoamine neurotransmitter imbalance, increase Brain-derived neurotrophic factor (BDNF) expression levels in the hippocampus, to modulate the composition and distribution of gut microbiota, and to increase the abundance of probiotics after continuous gavage of MOO for 28 days. MOO further confirmed that sexual dysfunction is closely related to the development of depression by improving the lack of sexual motivation and low sexual performance in CUMS-induced depressed mice, modulating the disruption of sex hormone secretion in serum, and alleviating sperm morphology and functional defects in the epididymis.ConclusionThese findings on MOO provide a basis for exploring its antidepressant mechanism, its use to improve hypogonadotropic symptoms, and for future development of new antidepressant drug to improves hypogonadotropic symptoms.https://www.frontiersin.org/articles/10.3389/fnins.2024.1509543/fullMorinda officinalis oligosaccharidesdepressionCUMSBDNF/TrkB/CREB pathwaygut microbiotasexual dysfunction |
| spellingShingle | Mengjie He Mengying Hu Tingqiao Wang Zeping Zuo Hongkai Li Zhiwei Zhao Yunwen Hao Xueling Dai Jianfang Wang Yaxuan Sun Morinda officinalis oligosaccharides alleviate chronic unpredictable mild stress-induced depression through the BDNF/TrkB/CREB pathway and symptoms of sexual dysfunction in mice Frontiers in Neuroscience Morinda officinalis oligosaccharides depression CUMS BDNF/TrkB/CREB pathway gut microbiota sexual dysfunction |
| title | Morinda officinalis oligosaccharides alleviate chronic unpredictable mild stress-induced depression through the BDNF/TrkB/CREB pathway and symptoms of sexual dysfunction in mice |
| title_full | Morinda officinalis oligosaccharides alleviate chronic unpredictable mild stress-induced depression through the BDNF/TrkB/CREB pathway and symptoms of sexual dysfunction in mice |
| title_fullStr | Morinda officinalis oligosaccharides alleviate chronic unpredictable mild stress-induced depression through the BDNF/TrkB/CREB pathway and symptoms of sexual dysfunction in mice |
| title_full_unstemmed | Morinda officinalis oligosaccharides alleviate chronic unpredictable mild stress-induced depression through the BDNF/TrkB/CREB pathway and symptoms of sexual dysfunction in mice |
| title_short | Morinda officinalis oligosaccharides alleviate chronic unpredictable mild stress-induced depression through the BDNF/TrkB/CREB pathway and symptoms of sexual dysfunction in mice |
| title_sort | morinda officinalis oligosaccharides alleviate chronic unpredictable mild stress induced depression through the bdnf trkb creb pathway and symptoms of sexual dysfunction in mice |
| topic | Morinda officinalis oligosaccharides depression CUMS BDNF/TrkB/CREB pathway gut microbiota sexual dysfunction |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2024.1509543/full |
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