Effect of zinc oxide nanoparticles with matrix metalloproteinase inhibitors on the shear bond strength of a universal dentin bonding agent to caries affected dentin
Objective: This study evaluated the effect of zinc oxide (ZnO) nanoparticles combined with matrix metalloproteinase (MMP) inhibitors on the shear bond strength (SBS) of a universal bonding agent to caries-affected dentin (CAD).Methods: Forty extracted molar teeth were ground to expose dentin. CAD wa...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Mashhad University of Medical Sciences
2024-12-01
|
| Series: | Journal of Dental Materials and Techniques |
| Subjects: | |
| Online Access: | https://jdmt.mums.ac.ir/article_25375_5fa2fe4b5609af4431a34e4a868fb25f.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841527885871972352 |
|---|---|
| author | Divyanshi Agarwal Srinidhi Surya Raghavendra Shalini Aggarwal Neil Lewis Pushpal Ingle |
| author_facet | Divyanshi Agarwal Srinidhi Surya Raghavendra Shalini Aggarwal Neil Lewis Pushpal Ingle |
| author_sort | Divyanshi Agarwal |
| collection | DOAJ |
| description | Objective: This study evaluated the effect of zinc oxide (ZnO) nanoparticles combined with matrix metalloproteinase (MMP) inhibitors on the shear bond strength (SBS) of a universal bonding agent to caries-affected dentin (CAD).Methods: Forty extracted molar teeth were ground to expose dentin. CAD was induced by immersing specimens in 10% citric acid for 4 hours. Samples were divided into five groups (n=8) based on the surface treatment following acid etching: Group 1: CAD treated with hesperidin, Group 2: CAD treated with ZnO nanoparticles and hesperidin, Group 3: CAD treated with grape seed extract, Group 4: CAD treated with ZnO nanoparticles and grape seed extract, and Group V: Control (no surface treatment). G-Premio Bond was applied and then composite resin cylinders were bonded to the dentin surface. After thermocycling, the bond strength of the specimens was measured using a universal testing machine. The data were analyzed by ANOVA and Tukey’s post hoc test, at a significance level of P < 0.05.Results: A significant difference in SBS was observed between the study groups (P < 0.001). Group 2 demonstrated the highest SBS (9.73 ± 0.37 MPa), followed by group 4 (8.76 ± 0.11 MPa), group 1 (7.68 ± 0.27 MPa), and group 3 (6.47 ± 0.34 MPa). The lowest bond strength was observed in the control group (4.32 ± 0.46 MPa). All pairwise intergroup comparisons were statistically significant (P < 0. 05).Conclusions: Surface treatment with ZnO nanoparticles and MMP inhibitors enhances the bond strength of universal bonding agents to caries-affected dentin. |
| format | Article |
| id | doaj-art-330b55323bb84a4aa08f4b4b1c2bea2f |
| institution | Kabale University |
| issn | 2322-4150 2252-0317 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Journal of Dental Materials and Techniques |
| spelling | doaj-art-330b55323bb84a4aa08f4b4b1c2bea2f2025-01-15T05:33:18ZengMashhad University of Medical SciencesJournal of Dental Materials and Techniques2322-41502252-03172024-12-0113419520010.22038/jdmt.2024.81294.167725375Effect of zinc oxide nanoparticles with matrix metalloproteinase inhibitors on the shear bond strength of a universal dentin bonding agent to caries affected dentinDivyanshi Agarwal0Srinidhi Surya Raghavendra1Shalini Aggarwal2Neil Lewis3Pushpal Ingle4Department of Conservative Dentistry and Endodontics, Dr. D.Y Patil Dental College and Hospital, Pimpri, Maharashtra, India.Department of Conservative Dentistry and Endodontics, Dr. D.Y Patil Dental College and Hospital, Pimpri, Maharashtra, India.Department of Conservative Dentistry and Endodontics, Dr. D.Y Patil Dental College and Hospital, Pimpri, Maharashtra, India.Department of Conservative Dentistry and Endodontics, Dr. D.Y Patil Dental College and Hospital, Pimpri, Maharashtra, India.Department of Conservative Dentistry and Endodontics, Dr. D.Y Patil Dental College and Hospital, Pimpri, Maharashtra, India.Objective: This study evaluated the effect of zinc oxide (ZnO) nanoparticles combined with matrix metalloproteinase (MMP) inhibitors on the shear bond strength (SBS) of a universal bonding agent to caries-affected dentin (CAD).Methods: Forty extracted molar teeth were ground to expose dentin. CAD was induced by immersing specimens in 10% citric acid for 4 hours. Samples were divided into five groups (n=8) based on the surface treatment following acid etching: Group 1: CAD treated with hesperidin, Group 2: CAD treated with ZnO nanoparticles and hesperidin, Group 3: CAD treated with grape seed extract, Group 4: CAD treated with ZnO nanoparticles and grape seed extract, and Group V: Control (no surface treatment). G-Premio Bond was applied and then composite resin cylinders were bonded to the dentin surface. After thermocycling, the bond strength of the specimens was measured using a universal testing machine. The data were analyzed by ANOVA and Tukey’s post hoc test, at a significance level of P < 0.05.Results: A significant difference in SBS was observed between the study groups (P < 0.001). Group 2 demonstrated the highest SBS (9.73 ± 0.37 MPa), followed by group 4 (8.76 ± 0.11 MPa), group 1 (7.68 ± 0.27 MPa), and group 3 (6.47 ± 0.34 MPa). The lowest bond strength was observed in the control group (4.32 ± 0.46 MPa). All pairwise intergroup comparisons were statistically significant (P < 0. 05).Conclusions: Surface treatment with ZnO nanoparticles and MMP inhibitors enhances the bond strength of universal bonding agents to caries-affected dentin.https://jdmt.mums.ac.ir/article_25375_5fa2fe4b5609af4431a34e4a868fb25f.pdfdental carieshesperidingrape seed extractmatrix metalloproteinase inhibitorszinc oxidenanoparticles |
| spellingShingle | Divyanshi Agarwal Srinidhi Surya Raghavendra Shalini Aggarwal Neil Lewis Pushpal Ingle Effect of zinc oxide nanoparticles with matrix metalloproteinase inhibitors on the shear bond strength of a universal dentin bonding agent to caries affected dentin Journal of Dental Materials and Techniques dental caries hesperidin grape seed extract matrix metalloproteinase inhibitors zinc oxide nanoparticles |
| title | Effect of zinc oxide nanoparticles with matrix metalloproteinase inhibitors on the shear bond strength of a universal dentin bonding agent to caries affected dentin |
| title_full | Effect of zinc oxide nanoparticles with matrix metalloproteinase inhibitors on the shear bond strength of a universal dentin bonding agent to caries affected dentin |
| title_fullStr | Effect of zinc oxide nanoparticles with matrix metalloproteinase inhibitors on the shear bond strength of a universal dentin bonding agent to caries affected dentin |
| title_full_unstemmed | Effect of zinc oxide nanoparticles with matrix metalloproteinase inhibitors on the shear bond strength of a universal dentin bonding agent to caries affected dentin |
| title_short | Effect of zinc oxide nanoparticles with matrix metalloproteinase inhibitors on the shear bond strength of a universal dentin bonding agent to caries affected dentin |
| title_sort | effect of zinc oxide nanoparticles with matrix metalloproteinase inhibitors on the shear bond strength of a universal dentin bonding agent to caries affected dentin |
| topic | dental caries hesperidin grape seed extract matrix metalloproteinase inhibitors zinc oxide nanoparticles |
| url | https://jdmt.mums.ac.ir/article_25375_5fa2fe4b5609af4431a34e4a868fb25f.pdf |
| work_keys_str_mv | AT divyanshiagarwal effectofzincoxidenanoparticleswithmatrixmetalloproteinaseinhibitorsontheshearbondstrengthofauniversaldentinbondingagenttocariesaffecteddentin AT srinidhisuryaraghavendra effectofzincoxidenanoparticleswithmatrixmetalloproteinaseinhibitorsontheshearbondstrengthofauniversaldentinbondingagenttocariesaffecteddentin AT shaliniaggarwal effectofzincoxidenanoparticleswithmatrixmetalloproteinaseinhibitorsontheshearbondstrengthofauniversaldentinbondingagenttocariesaffecteddentin AT neillewis effectofzincoxidenanoparticleswithmatrixmetalloproteinaseinhibitorsontheshearbondstrengthofauniversaldentinbondingagenttocariesaffecteddentin AT pushpalingle effectofzincoxidenanoparticleswithmatrixmetalloproteinaseinhibitorsontheshearbondstrengthofauniversaldentinbondingagenttocariesaffecteddentin |