Influence of Heat Treatment of Nitinol Wire on the Properties of Nitinol/Hybrid Layer for Ibuprofen Release
The efficiency of drug delivery from coatings of metallic implants is one of the key factors. The influence of chemical and thermal treatments of nitinol wire on the corrosion properties, deposition of hydroxyapatite(HA)/poly ε-caprolactone-polyethylene glycol (PEG-<i>b</i>-PCL), and the...
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MDPI AG
2024-11-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/29/21/5200 |
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| author | Robert Mroczka Agnieszka Słodkowska Jerzy Kubacki |
| author_facet | Robert Mroczka Agnieszka Słodkowska Jerzy Kubacki |
| author_sort | Robert Mroczka |
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| description | The efficiency of drug delivery from coatings of metallic implants is one of the key factors. The influence of chemical and thermal treatments of nitinol wire on the corrosion properties, deposition of hydroxyapatite(HA)/poly ε-caprolactone-polyethylene glycol (PEG-<i>b</i>-PCL), and the amount of ibuprofen released from that bilayer were studied. The hydroxyapatite layer was electrodeposited by pulse current, while the PEG-<i>b</i>-PCL layer was by drop-coating. It was shown that nitinol wire, chemically treated and thermally heated at 470 °C under optimized conditions, is the most optimal substrate for the deposition of uniform and compact hybrid HA/(PEG-<i>b</i>-PCL) bilayer. Ibuprofen incorporated into this hybrid bilayer exhibits the maximum release into phosphate-buffered saline (PBS) solution. About 80% of ibuprofen is released within 5 h. |
| format | Article |
| id | doaj-art-330897f764cd49a3b09b5cd18c74592a |
| institution | Kabale University |
| issn | 1420-3049 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj-art-330897f764cd49a3b09b5cd18c74592a2024-11-08T14:38:39ZengMDPI AGMolecules1420-30492024-11-012921520010.3390/molecules29215200Influence of Heat Treatment of Nitinol Wire on the Properties of Nitinol/Hybrid Layer for Ibuprofen ReleaseRobert Mroczka0Agnieszka Słodkowska1Jerzy Kubacki2Laboratory of X-ray Optics, Department of Chemistry, Institute of Biological Sciences, Faculty of Medicine, The John Paul II Catholic University of Lublin, Konstantynów 1J, 20-708 Lublin, PolandLaboratory of X-ray Optics, Department of Chemistry, Institute of Biological Sciences, Faculty of Medicine, The John Paul II Catholic University of Lublin, Konstantynów 1J, 20-708 Lublin, PolandFaculty of Science and Technology, A. Chełkowski Institute of Physics, University of Silesia in Katowice, 75 Pulku Piechoty 1A, 41-500 Chorzow, PolandThe efficiency of drug delivery from coatings of metallic implants is one of the key factors. The influence of chemical and thermal treatments of nitinol wire on the corrosion properties, deposition of hydroxyapatite(HA)/poly ε-caprolactone-polyethylene glycol (PEG-<i>b</i>-PCL), and the amount of ibuprofen released from that bilayer were studied. The hydroxyapatite layer was electrodeposited by pulse current, while the PEG-<i>b</i>-PCL layer was by drop-coating. It was shown that nitinol wire, chemically treated and thermally heated at 470 °C under optimized conditions, is the most optimal substrate for the deposition of uniform and compact hybrid HA/(PEG-<i>b</i>-PCL) bilayer. Ibuprofen incorporated into this hybrid bilayer exhibits the maximum release into phosphate-buffered saline (PBS) solution. About 80% of ibuprofen is released within 5 h.https://www.mdpi.com/1420-3049/29/21/5200drug delivery systemshydroxyapatite electrodepositionnitinol heat treatment |
| spellingShingle | Robert Mroczka Agnieszka Słodkowska Jerzy Kubacki Influence of Heat Treatment of Nitinol Wire on the Properties of Nitinol/Hybrid Layer for Ibuprofen Release Molecules drug delivery systems hydroxyapatite electrodeposition nitinol heat treatment |
| title | Influence of Heat Treatment of Nitinol Wire on the Properties of Nitinol/Hybrid Layer for Ibuprofen Release |
| title_full | Influence of Heat Treatment of Nitinol Wire on the Properties of Nitinol/Hybrid Layer for Ibuprofen Release |
| title_fullStr | Influence of Heat Treatment of Nitinol Wire on the Properties of Nitinol/Hybrid Layer for Ibuprofen Release |
| title_full_unstemmed | Influence of Heat Treatment of Nitinol Wire on the Properties of Nitinol/Hybrid Layer for Ibuprofen Release |
| title_short | Influence of Heat Treatment of Nitinol Wire on the Properties of Nitinol/Hybrid Layer for Ibuprofen Release |
| title_sort | influence of heat treatment of nitinol wire on the properties of nitinol hybrid layer for ibuprofen release |
| topic | drug delivery systems hydroxyapatite electrodeposition nitinol heat treatment |
| url | https://www.mdpi.com/1420-3049/29/21/5200 |
| work_keys_str_mv | AT robertmroczka influenceofheattreatmentofnitinolwireonthepropertiesofnitinolhybridlayerforibuprofenrelease AT agnieszkasłodkowska influenceofheattreatmentofnitinolwireonthepropertiesofnitinolhybridlayerforibuprofenrelease AT jerzykubacki influenceofheattreatmentofnitinolwireonthepropertiesofnitinolhybridlayerforibuprofenrelease |