Electrically conductive biopolymer-based hydrogels and fibrous materials fabricated using 3D printing and electrospinning for cardiac tissue engineering
Cardiovascular diseases pose a significant global health challenge, driving ongoing efforts to develop effective treatments. Various biofabrication technologies utilizing numerous materials have been employed to design functional cardiac tissues. Choosing the right material is crucial to support car...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
KeAi Communications Co., Ltd.
2025-09-01
|
| Series: | Bioactive Materials |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X25002002 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849249610028023808 |
|---|---|
| author | Arnaud Kamdem Tamo Ingo Doench Kaveh Roshanbinfar Alexandra Montembault Anatoli Serghei Felix B. Engel Anayancy Osorio-Madrazo |
| author_facet | Arnaud Kamdem Tamo Ingo Doench Kaveh Roshanbinfar Alexandra Montembault Anatoli Serghei Felix B. Engel Anayancy Osorio-Madrazo |
| author_sort | Arnaud Kamdem Tamo |
| collection | DOAJ |
| description | Cardiovascular diseases pose a significant global health challenge, driving ongoing efforts to develop effective treatments. Various biofabrication technologies utilizing numerous materials have been employed to design functional cardiac tissues. Choosing the right material is crucial to support cardiac cell growth, proliferation, tissue maturation and functionality. 3D printing enables the fabrication of structures that mimic the hierarchical organization of native cardiac tissue, further enhancing its function. Electrospinning produces nanofibrous scaffolds with a high surface area and porosity, mimicking the extracellular matrix and promoting the cell behaviors required for tissue formation. Although typically employed independently, combining these technologies can enable the fabrication of patches with properties closely resembling those of native cardiac tissues. Recent research focuses on the use of electroconductive materials, which enhance cell-to-cell communication and promote the maturation of cardiomyocytes, thereby preventing arrhythmic contractions and improving the functionality of engineered cardiac tissues. In this review, recent studies showcasing the applications of electroconductive biopolymer-based fibrous materials and hydrogels designed using 3D printing and/or electrospinning for cardiac tissue engineering are discussed. Furthermore, the review evaluates the synergistic effects of biopolymer-based materials and electrical components in 3D printed electroconductive hydrogels. It also discusses the challenges faced in fabricating these hydrogels and explores their future prospects for biomedical applications. |
| format | Article |
| id | doaj-art-3300a1535da34e53b3f9f56ccd71effe |
| institution | Kabale University |
| issn | 2452-199X |
| language | English |
| publishDate | 2025-09-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj-art-3300a1535da34e53b3f9f56ccd71effe2025-08-20T03:57:31ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2025-09-015165071910.1016/j.bioactmat.2025.05.014Electrically conductive biopolymer-based hydrogels and fibrous materials fabricated using 3D printing and electrospinning for cardiac tissue engineeringArnaud Kamdem Tamo0Ingo Doench1Kaveh Roshanbinfar2Alexandra Montembault3Anatoli Serghei4Felix B. Engel5Anayancy Osorio-Madrazo6Laboratory of Organ Printing, University of Bayreuth, 95447, Bayreuth, Germany; Laboratory for Bioinspired Materials for Biomedical Engineering, Department of Microsystems Engineering IMTEK, University of Freiburg, 79110, Freiburg, Germany; Ingénierie des Matériaux Polymères (IMP), UMR 5223, Université Claude Bernard Lyon 1, CNRS, INSA Lyon, Université Jean Monnet, 69622, Villeurbanne, France; Department of Nephropathology, Experimental Renal and Cardiovascular Research, Institute of Pathology and Department of Cardiology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054, Erlangen, Germany; Corresponding author. Laboratory of Organ Printing, University of Bayreuth, 95447, Bayreuth, Germany.Laboratory of Organ Printing, University of Bayreuth, 95447, Bayreuth, Germany; Laboratory for Bioinspired Materials for Biomedical Engineering, Department of Microsystems Engineering IMTEK, University of Freiburg, 79110, Freiburg, GermanyDepartment of Nephropathology, Experimental Renal and Cardiovascular Research, Institute of Pathology and Department of Cardiology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054, Erlangen, GermanyIngénierie des Matériaux Polymères (IMP), UMR 5223, Université Claude Bernard Lyon 1, CNRS, INSA Lyon, Université Jean Monnet, 69622, Villeurbanne, FranceIngénierie des Matériaux Polymères (IMP), UMR 5223, Université Claude Bernard Lyon 1, CNRS, INSA Lyon, Université Jean Monnet, 69622, Villeurbanne, FranceDepartment of Nephropathology, Experimental Renal and Cardiovascular Research, Institute of Pathology and Department of Cardiology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054, Erlangen, Germany; Corresponding author. Department of Nephropathology, Experimental Renal and Cardiovascular Research, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054, Erlangen, Germany.Laboratory of Organ Printing, University of Bayreuth, 95447, Bayreuth, Germany; Laboratory for Bioinspired Materials for Biomedical Engineering, Department of Microsystems Engineering IMTEK, University of Freiburg, 79110, Freiburg, Germany; Corresponding author. Laboratory of Organ Printing, University of Bayreuth, 95447, Bayreuth, Germany.Cardiovascular diseases pose a significant global health challenge, driving ongoing efforts to develop effective treatments. Various biofabrication technologies utilizing numerous materials have been employed to design functional cardiac tissues. Choosing the right material is crucial to support cardiac cell growth, proliferation, tissue maturation and functionality. 3D printing enables the fabrication of structures that mimic the hierarchical organization of native cardiac tissue, further enhancing its function. Electrospinning produces nanofibrous scaffolds with a high surface area and porosity, mimicking the extracellular matrix and promoting the cell behaviors required for tissue formation. Although typically employed independently, combining these technologies can enable the fabrication of patches with properties closely resembling those of native cardiac tissues. Recent research focuses on the use of electroconductive materials, which enhance cell-to-cell communication and promote the maturation of cardiomyocytes, thereby preventing arrhythmic contractions and improving the functionality of engineered cardiac tissues. In this review, recent studies showcasing the applications of electroconductive biopolymer-based fibrous materials and hydrogels designed using 3D printing and/or electrospinning for cardiac tissue engineering are discussed. Furthermore, the review evaluates the synergistic effects of biopolymer-based materials and electrical components in 3D printed electroconductive hydrogels. It also discusses the challenges faced in fabricating these hydrogels and explores their future prospects for biomedical applications.http://www.sciencedirect.com/science/article/pii/S2452199X25002002Cardiac tissue engineering3D (bio)printingElectrospinningBiopolymer-based hydrogelsFiber-filled hydrogelsElectroconductive materials |
| spellingShingle | Arnaud Kamdem Tamo Ingo Doench Kaveh Roshanbinfar Alexandra Montembault Anatoli Serghei Felix B. Engel Anayancy Osorio-Madrazo Electrically conductive biopolymer-based hydrogels and fibrous materials fabricated using 3D printing and electrospinning for cardiac tissue engineering Bioactive Materials Cardiac tissue engineering 3D (bio)printing Electrospinning Biopolymer-based hydrogels Fiber-filled hydrogels Electroconductive materials |
| title | Electrically conductive biopolymer-based hydrogels and fibrous materials fabricated using 3D printing and electrospinning for cardiac tissue engineering |
| title_full | Electrically conductive biopolymer-based hydrogels and fibrous materials fabricated using 3D printing and electrospinning for cardiac tissue engineering |
| title_fullStr | Electrically conductive biopolymer-based hydrogels and fibrous materials fabricated using 3D printing and electrospinning for cardiac tissue engineering |
| title_full_unstemmed | Electrically conductive biopolymer-based hydrogels and fibrous materials fabricated using 3D printing and electrospinning for cardiac tissue engineering |
| title_short | Electrically conductive biopolymer-based hydrogels and fibrous materials fabricated using 3D printing and electrospinning for cardiac tissue engineering |
| title_sort | electrically conductive biopolymer based hydrogels and fibrous materials fabricated using 3d printing and electrospinning for cardiac tissue engineering |
| topic | Cardiac tissue engineering 3D (bio)printing Electrospinning Biopolymer-based hydrogels Fiber-filled hydrogels Electroconductive materials |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X25002002 |
| work_keys_str_mv | AT arnaudkamdemtamo electricallyconductivebiopolymerbasedhydrogelsandfibrousmaterialsfabricatedusing3dprintingandelectrospinningforcardiactissueengineering AT ingodoench electricallyconductivebiopolymerbasedhydrogelsandfibrousmaterialsfabricatedusing3dprintingandelectrospinningforcardiactissueengineering AT kavehroshanbinfar electricallyconductivebiopolymerbasedhydrogelsandfibrousmaterialsfabricatedusing3dprintingandelectrospinningforcardiactissueengineering AT alexandramontembault electricallyconductivebiopolymerbasedhydrogelsandfibrousmaterialsfabricatedusing3dprintingandelectrospinningforcardiactissueengineering AT anatoliserghei electricallyconductivebiopolymerbasedhydrogelsandfibrousmaterialsfabricatedusing3dprintingandelectrospinningforcardiactissueengineering AT felixbengel electricallyconductivebiopolymerbasedhydrogelsandfibrousmaterialsfabricatedusing3dprintingandelectrospinningforcardiactissueengineering AT anayancyosoriomadrazo electricallyconductivebiopolymerbasedhydrogelsandfibrousmaterialsfabricatedusing3dprintingandelectrospinningforcardiactissueengineering |