Representation of non-coding RNA-mediated regulation of gene expression using the Gene Ontology
Regulatory non-coding RNAs (ncRNAs) are increasingly recognized as integral to the control of biological processes. This is often through the targeted regulation of mRNA expression, but this is by no means the only mechanism through which regulatory ncRNAs act. The Gene Ontology (GO) has long been u...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | RNA Biology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/15476286.2024.2408523 |
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| author | Giulia Antonazzo Pascale Gaudet Ruth C. Lovering Helen Attrill |
| author_facet | Giulia Antonazzo Pascale Gaudet Ruth C. Lovering Helen Attrill |
| author_sort | Giulia Antonazzo |
| collection | DOAJ |
| description | Regulatory non-coding RNAs (ncRNAs) are increasingly recognized as integral to the control of biological processes. This is often through the targeted regulation of mRNA expression, but this is by no means the only mechanism through which regulatory ncRNAs act. The Gene Ontology (GO) has long been used for the systematic annotation of protein-coding and ncRNA gene function, but rapid progress in the understanding of ncRNAs meant that the ontology needed to be revised to accurately reflect current knowledge. Here, a targeted effort to revise GO terms used for the annotation of regulatory ncRNAs is described, focusing on microRNAs (miRNAs), long non-coding RNAs (lncRNAs), small interfering RNAs (siRNAs) and PIWI-interacting RNAs (piRNAs). This paper provides guidance to biocurators annotating ncRNA-mediated processes using the GO and serves as background for researchers wishing to make use of the GO in their studies of ncRNAs and the biological processes they regulate. |
| format | Article |
| id | doaj-art-32f12a305fae49e4a0b09c902363a06a |
| institution | Kabale University |
| issn | 1547-6286 1555-8584 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | RNA Biology |
| spelling | doaj-art-32f12a305fae49e4a0b09c902363a06a2024-12-11T07:55:05ZengTaylor & Francis GroupRNA Biology1547-62861555-85842024-12-0121198199310.1080/15476286.2024.2408523Representation of non-coding RNA-mediated regulation of gene expression using the Gene OntologyGiulia Antonazzo0Pascale Gaudet1Ruth C. Lovering2Helen Attrill3Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UKSIB Swiss Institute of Bioinformatics, Swiss-Prot Group, Geneva, SwitzerlandFunctional Gene Annotation, Institute of Cardiovascular Science, University College London, London, UKDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UKRegulatory non-coding RNAs (ncRNAs) are increasingly recognized as integral to the control of biological processes. This is often through the targeted regulation of mRNA expression, but this is by no means the only mechanism through which regulatory ncRNAs act. The Gene Ontology (GO) has long been used for the systematic annotation of protein-coding and ncRNA gene function, but rapid progress in the understanding of ncRNAs meant that the ontology needed to be revised to accurately reflect current knowledge. Here, a targeted effort to revise GO terms used for the annotation of regulatory ncRNAs is described, focusing on microRNAs (miRNAs), long non-coding RNAs (lncRNAs), small interfering RNAs (siRNAs) and PIWI-interacting RNAs (piRNAs). This paper provides guidance to biocurators annotating ncRNA-mediated processes using the GO and serves as background for researchers wishing to make use of the GO in their studies of ncRNAs and the biological processes they regulate.https://www.tandfonline.com/doi/10.1080/15476286.2024.2408523Gene Ontologynon-coding RNAbioinformaticsbiocurationgene silencingguidelines |
| spellingShingle | Giulia Antonazzo Pascale Gaudet Ruth C. Lovering Helen Attrill Representation of non-coding RNA-mediated regulation of gene expression using the Gene Ontology RNA Biology Gene Ontology non-coding RNA bioinformatics biocuration gene silencing guidelines |
| title | Representation of non-coding RNA-mediated regulation of gene expression using the Gene Ontology |
| title_full | Representation of non-coding RNA-mediated regulation of gene expression using the Gene Ontology |
| title_fullStr | Representation of non-coding RNA-mediated regulation of gene expression using the Gene Ontology |
| title_full_unstemmed | Representation of non-coding RNA-mediated regulation of gene expression using the Gene Ontology |
| title_short | Representation of non-coding RNA-mediated regulation of gene expression using the Gene Ontology |
| title_sort | representation of non coding rna mediated regulation of gene expression using the gene ontology |
| topic | Gene Ontology non-coding RNA bioinformatics biocuration gene silencing guidelines |
| url | https://www.tandfonline.com/doi/10.1080/15476286.2024.2408523 |
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