Effects of a ciliary neurotrophic factor (CNTF) small-molecule peptide mimetic in an in vitro and in vivo model of CDKL5 deficiency disorder

Effects of a ciliary neurotrophic factor (CNTF) small-molecule peptide mimetic in an in vitro and in vivo model of CDKL5 deficiency disorder

Abstract Background Mutations in the X-linked CDKL5 gene underlie a severe epileptic encephalopathy, CDKL5 deficiency disorder (CDD), characterized by gross motor impairment, autistic features and intellectual disability. Absence of Cdkl5 negatively impacts neuronal proliferation, survival, and matu...

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Bibliographic Details
Main Authors: Nicola Mottolese, Manuela Loi, Stefania Trazzi, Marianna Tassinari, Beatrice Uguagliati, Giulia Candini, Khalid Iqbal, Giorgio Medici, Elisabetta Ciani
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Journal of Neurodevelopmental Disorders
Subjects:
Cdkl5 KO mice
CNTF
Brain development
Dendritic pathology
Neuronal survival
Neuroinflammation
Online Access:https://doi.org/10.1186/s11689-024-09583-4
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