Multistep Modelling and Monitoring of Bioprocesses
A new approach is proposed for modelling and monitoring bioprocesses dynamics characterized by different metabolic states. Bioprocesses cannot be described by a single model. For this reason, three phases characterised by the bioprocess are defined – periodic, exponential, and stationary. During eac...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Bulgarian Academy of Sciences
2024-12-01
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| Series: | International Journal Bioautomation |
| Subjects: | |
| Online Access: | http://www.biomed.bas.bg/bioautomation/2024/vol_28.4/files/28.4_01.pdf |
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| Summary: | A new approach is proposed for modelling and monitoring bioprocesses dynamics characterized by different metabolic states. Bioprocesses cannot be described by a single model. For this reason, three phases characterised by the bioprocess are defined – periodic, exponential, and stationary. During each phase, the process passes through one or more physiological states. Each physiological state is described by a sub-model with a different structure and parameter values. The transition of the process from one physiological state to another is carried out by switching the sub-models based on a predefined key parameter. Monitoring is performed by a cascade of software sensors using the sub-models and real-time measurement of the concentrations of the main process variables. The proposed approach was tested by modelling and monitoring the Escherichia coli phytase production process. |
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| ISSN: | 1314-1902 1314-2321 |