Efficient Gene-Editing in Human Pluripotent Stem Cells Through Simplified Assembly of Adeno-Associated Viral (AAV) Donor Templates

Efficient Gene-Editing in Human Pluripotent Stem Cells Through Simplified Assembly of Adeno-Associated Viral (AAV) Donor Templates

Gene-edited human pluripotent stem cells provide attractive model systems to functionally interrogate the role of specific genetic variants in relevant cell types. However, the need to isolate and screen edited clones often remains a bottleneck, in particular when recombination rates are sub-optimal...

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Main Authors: Berta de La Cruz, Sanhita Mitra, Bingqing He, Melis Çelik, Debora Kaminski, Erik Smedler, Fredrik Sterky
Format: Article
Language:English
Published: Bio-protocol LLC 2024-11-01
Series:Bio-Protocol
Online Access:https://bio-protocol.org/en/bpdetail?id=5097&type=0
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