Comparison of subfoveal choroidal thickness in pre-eclamptic, healthy pregnant, and non-pregnant women
Purpose: The purpose of the study was to compare the choroidal thickness (CT) in pre-eclamptic (PE), healthy pregnant, and age-matched healthy non-pregnant females by spectral-domain optical coherence tomography (SD-OCT) and to investigate any possible correlation between subfoveal CT (SFCT) and mea...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-01-01
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| Series: | Indian Journal of Ophthalmology |
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| Online Access: | https://journals.lww.com/10.4103/IJO.IJO_767_24 |
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| author | Aarshi Naharwal Ramanuj Samanta Ajai Agrawal Latika Chawla Amrita Gaurav Sreeram Jayaraj |
| author_facet | Aarshi Naharwal Ramanuj Samanta Ajai Agrawal Latika Chawla Amrita Gaurav Sreeram Jayaraj |
| author_sort | Aarshi Naharwal |
| collection | DOAJ |
| description | Purpose:
The purpose of the study was to compare the choroidal thickness (CT) in pre-eclamptic (PE), healthy pregnant, and age-matched healthy non-pregnant females by spectral-domain optical coherence tomography (SD-OCT) and to investigate any possible correlation between subfoveal CT (SFCT) and mean arterial pressure (MAP) in PE.
Methods:
This was a hospital-based, comparative study. A total of 90 females (30 in each group) aged 20-40 years were recruited prospectively over 1 year. Females with refractive error beyond ±3 D, intraocular pressure >21 mmHg, prior ocular trauma or surgeries, systemic diseases, pregnancy-related complications (except PE), and poor OCT scans were excluded. Following comprehensive ophthalmic evaluation, CT was measured bilaterally using SD-OCT (EDI) at the subfoveal region and at 1500 µm nasal and temporal to fovea. Systolic and diastolic blood pressures were recorded in all.
Results:
The PE group had significantly thinner choroid (SFCT: 337.5 ± 49.8 OD, 333.0 ± 50.8 OS) as compared to the healthy non-pregnant group (SFCT: 351.6 ± 34.4 OD, 365.3 ± 33.6 OS) and healthy pregnant group (SFCT: 374.2 ± 44.1 OD, 377.2 ± 49.5 OS) (P < 0.05) in all locations (nasal, temporal, and subfoveal) in both eyes (except for OD nasal CT). However, there was no significant correlation between SFCT and MAP in the PE group.
Conclusion:
Significantly lower CT in PE without any direct correlation between SFCT and MAP may implicate that choroidal thinning in PE is governed by multifactorial choroidal vasospasm and endothelial dysfunction, instead of MAP solely. |
| format | Article |
| id | doaj-art-326113b4d9db450fb8a91464614d6d87 |
| institution | Kabale University |
| issn | 0301-4738 1998-3689 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Ophthalmology |
| spelling | doaj-art-326113b4d9db450fb8a91464614d6d872025-01-07T06:28:38ZengWolters Kluwer Medknow PublicationsIndian Journal of Ophthalmology0301-47381998-36892025-01-0173Suppl 1S151S15710.4103/IJO.IJO_767_24Comparison of subfoveal choroidal thickness in pre-eclamptic, healthy pregnant, and non-pregnant womenAarshi NaharwalRamanuj SamantaAjai AgrawalLatika ChawlaAmrita GauravSreeram JayarajPurpose: The purpose of the study was to compare the choroidal thickness (CT) in pre-eclamptic (PE), healthy pregnant, and age-matched healthy non-pregnant females by spectral-domain optical coherence tomography (SD-OCT) and to investigate any possible correlation between subfoveal CT (SFCT) and mean arterial pressure (MAP) in PE. Methods: This was a hospital-based, comparative study. A total of 90 females (30 in each group) aged 20-40 years were recruited prospectively over 1 year. Females with refractive error beyond ±3 D, intraocular pressure >21 mmHg, prior ocular trauma or surgeries, systemic diseases, pregnancy-related complications (except PE), and poor OCT scans were excluded. Following comprehensive ophthalmic evaluation, CT was measured bilaterally using SD-OCT (EDI) at the subfoveal region and at 1500 µm nasal and temporal to fovea. Systolic and diastolic blood pressures were recorded in all. Results: The PE group had significantly thinner choroid (SFCT: 337.5 ± 49.8 OD, 333.0 ± 50.8 OS) as compared to the healthy non-pregnant group (SFCT: 351.6 ± 34.4 OD, 365.3 ± 33.6 OS) and healthy pregnant group (SFCT: 374.2 ± 44.1 OD, 377.2 ± 49.5 OS) (P < 0.05) in all locations (nasal, temporal, and subfoveal) in both eyes (except for OD nasal CT). However, there was no significant correlation between SFCT and MAP in the PE group. Conclusion: Significantly lower CT in PE without any direct correlation between SFCT and MAP may implicate that choroidal thinning in PE is governed by multifactorial choroidal vasospasm and endothelial dysfunction, instead of MAP solely.https://journals.lww.com/10.4103/IJO.IJO_767_24choroidal changes in pregnancychoroidal thicknesspre-eclampsiapregnancyspectral-domain oct |
| spellingShingle | Aarshi Naharwal Ramanuj Samanta Ajai Agrawal Latika Chawla Amrita Gaurav Sreeram Jayaraj Comparison of subfoveal choroidal thickness in pre-eclamptic, healthy pregnant, and non-pregnant women Indian Journal of Ophthalmology choroidal changes in pregnancy choroidal thickness pre-eclampsia pregnancy spectral-domain oct |
| title | Comparison of subfoveal choroidal thickness in pre-eclamptic, healthy pregnant, and non-pregnant women |
| title_full | Comparison of subfoveal choroidal thickness in pre-eclamptic, healthy pregnant, and non-pregnant women |
| title_fullStr | Comparison of subfoveal choroidal thickness in pre-eclamptic, healthy pregnant, and non-pregnant women |
| title_full_unstemmed | Comparison of subfoveal choroidal thickness in pre-eclamptic, healthy pregnant, and non-pregnant women |
| title_short | Comparison of subfoveal choroidal thickness in pre-eclamptic, healthy pregnant, and non-pregnant women |
| title_sort | comparison of subfoveal choroidal thickness in pre eclamptic healthy pregnant and non pregnant women |
| topic | choroidal changes in pregnancy choroidal thickness pre-eclampsia pregnancy spectral-domain oct |
| url | https://journals.lww.com/10.4103/IJO.IJO_767_24 |
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