Photobiomodulation and Its Therapeutic Potential in Sleep Disturbances
Photobiomodulation (PBM) is a non-invasive therapeutic technique employing specific wavelengths of red and near-infrared light to induce photochemical reactions in biological tissues without generating significant heat. PBM operates at low power densities, primarily acting through mitochondrial chro...
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| Format: | Article |
| Language: | English |
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Korean Society of Sleep Medicine
2024-12-01
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| Series: | Sleep Medicine Research |
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| Online Access: | http://sleepmedres.org/upload/pdf/smr-2024-02593.pdf |
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| author | Jieun Jung Tae Kim |
| author_facet | Jieun Jung Tae Kim |
| author_sort | Jieun Jung |
| collection | DOAJ |
| description | Photobiomodulation (PBM) is a non-invasive therapeutic technique employing specific wavelengths of red and near-infrared light to induce photochemical reactions in biological tissues without generating significant heat. PBM operates at low power densities, primarily acting through mitochondrial chromophores like cytochrome c oxidase to enhance cellular metabolism, energy production, and repair mechanisms. Based upon this foundational understanding, a critical evaluation was conducted to assess its impact on sleep-wake regulation. Current scientific evidence from both preclinical and clinical research suggests that PBM has the potential to influence sleep architecture, duration, and quality through complex interactions with cellular metabolic pathways and neurophysiological mechanisms governing the sleep-wake cycle. Despite growing scientific interest, significant research gaps persist; elucidating the precise cellular and molecular mechanisms by which PBM affects sleep physiology remains a primary challenge. There is an urgent need to standardize intervention protocols, including determining optimal wavelengths, dosage parameters, treatment durations, and delivery methods, to ensure consistent and reproducible results. Future research should focus on identifying predictive biomarkers for personalized treatment, examining transcranial PBM’s effects on neural pathways involved in sleep regulation, and assessing long-term safety to address potential cumulative effects. In conclusion, while PBM shows promise as a non-invasive therapeutic approach for sleep regulation, rigorous research is needed to establish its clinical efficacy and understand its molecular mechanisms, ultimately advancing it from an experimental therapy to a standardized treatment for sleep disorders. |
| format | Article |
| id | doaj-art-32506441f94f4fefaeb3e3f7c19545c8 |
| institution | Kabale University |
| issn | 2093-9175 2233-8853 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Korean Society of Sleep Medicine |
| record_format | Article |
| series | Sleep Medicine Research |
| spelling | doaj-art-32506441f94f4fefaeb3e3f7c19545c82025-01-14T06:14:41ZengKorean Society of Sleep MedicineSleep Medicine Research2093-91752233-88532024-12-0115421822710.17241/smr.2024.02593297Photobiomodulation and Its Therapeutic Potential in Sleep DisturbancesJieun Jung0Tae Kim1 Sleep Research Lab, TEDi MEDi. Co., Ltd., Gwangju, Korea Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, KoreaPhotobiomodulation (PBM) is a non-invasive therapeutic technique employing specific wavelengths of red and near-infrared light to induce photochemical reactions in biological tissues without generating significant heat. PBM operates at low power densities, primarily acting through mitochondrial chromophores like cytochrome c oxidase to enhance cellular metabolism, energy production, and repair mechanisms. Based upon this foundational understanding, a critical evaluation was conducted to assess its impact on sleep-wake regulation. Current scientific evidence from both preclinical and clinical research suggests that PBM has the potential to influence sleep architecture, duration, and quality through complex interactions with cellular metabolic pathways and neurophysiological mechanisms governing the sleep-wake cycle. Despite growing scientific interest, significant research gaps persist; elucidating the precise cellular and molecular mechanisms by which PBM affects sleep physiology remains a primary challenge. There is an urgent need to standardize intervention protocols, including determining optimal wavelengths, dosage parameters, treatment durations, and delivery methods, to ensure consistent and reproducible results. Future research should focus on identifying predictive biomarkers for personalized treatment, examining transcranial PBM’s effects on neural pathways involved in sleep regulation, and assessing long-term safety to address potential cumulative effects. In conclusion, while PBM shows promise as a non-invasive therapeutic approach for sleep regulation, rigorous research is needed to establish its clinical efficacy and understand its molecular mechanisms, ultimately advancing it from an experimental therapy to a standardized treatment for sleep disorders.http://sleepmedres.org/upload/pdf/smr-2024-02593.pdfsleepphotobiomodulationsleep disordersphototherapylow-level light therapy |
| spellingShingle | Jieun Jung Tae Kim Photobiomodulation and Its Therapeutic Potential in Sleep Disturbances Sleep Medicine Research sleep photobiomodulation sleep disorders phototherapy low-level light therapy |
| title | Photobiomodulation and Its Therapeutic Potential in Sleep Disturbances |
| title_full | Photobiomodulation and Its Therapeutic Potential in Sleep Disturbances |
| title_fullStr | Photobiomodulation and Its Therapeutic Potential in Sleep Disturbances |
| title_full_unstemmed | Photobiomodulation and Its Therapeutic Potential in Sleep Disturbances |
| title_short | Photobiomodulation and Its Therapeutic Potential in Sleep Disturbances |
| title_sort | photobiomodulation and its therapeutic potential in sleep disturbances |
| topic | sleep photobiomodulation sleep disorders phototherapy low-level light therapy |
| url | http://sleepmedres.org/upload/pdf/smr-2024-02593.pdf |
| work_keys_str_mv | AT jieunjung photobiomodulationanditstherapeuticpotentialinsleepdisturbances AT taekim photobiomodulationanditstherapeuticpotentialinsleepdisturbances |