Functionalized Amyloid‐Like Protein Nanofilm‐Mediated Synergistic Disulfidptosis and Photodynamic Therapy for Preventing Postoperative Recurrence of Colorectal Cancer
Colorectal cancer (CRC) has a postoperative recurrence rate of up to 50%. Local treatment at the surgical site offers a new strategy to prevent recurrence, minimizing systemic side effects. However, these treatments often face issues like poor stability, insufficient targeting, and significant local...
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2024-11-01
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| Series: | Small Science |
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| Online Access: | https://doi.org/10.1002/smsc.202400323 |
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| author | Man Zhang Ke Li Junhao Kou Guozhi Lu Ling Qiu Chunzhao Yang Yongchun Liu Qi Xue Peng Yang |
| author_facet | Man Zhang Ke Li Junhao Kou Guozhi Lu Ling Qiu Chunzhao Yang Yongchun Liu Qi Xue Peng Yang |
| author_sort | Man Zhang |
| collection | DOAJ |
| description | Colorectal cancer (CRC) has a postoperative recurrence rate of up to 50%. Local treatment at the surgical site offers a new strategy to prevent recurrence, minimizing systemic side effects. However, these treatments often face issues like poor stability, insufficient targeting, and significant local side effects. Research shows glucose starvation can induce disulfidptosis, a novel cell death pathway, in CRC cells, suitable for precise intervention in residual tumor cells postsurgery. This study develops a biocompatible 2D therapeutic platform using amyloid‐like protein nanofilm technology for precise local synergistic intervention in disulfidptosis and photodynamic therapy (PDT) after CRC surgery. The nanofilm boasts excellent drug‐loading capacity, enzyme activity retention, ultrathin dimensions, wet adhesion, and biocompatibility. A model simulating incomplete tumor resection post‐CRC surgery shows that the GCI@nanofilm effectively inhibits recurrence through an enzyme‐catalyzed cascade reaction inducing disulfidptosis and synergizing with PDT. In summary, GCI@nanofilm overcomes multiple challenges in local postsurgical intervention, providing a foundation for precise and efficient treatment of residual tumors. |
| format | Article |
| id | doaj-art-3236ab98d7ab48b788e42a0a7cfc7b93 |
| institution | Kabale University |
| issn | 2688-4046 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Small Science |
| spelling | doaj-art-3236ab98d7ab48b788e42a0a7cfc7b932024-11-11T15:33:39ZengWiley-VCHSmall Science2688-40462024-11-01411n/an/a10.1002/smsc.202400323Functionalized Amyloid‐Like Protein Nanofilm‐Mediated Synergistic Disulfidptosis and Photodynamic Therapy for Preventing Postoperative Recurrence of Colorectal CancerMan Zhang0Ke Li1Junhao Kou2Guozhi Lu3Ling Qiu4Chunzhao Yang5Yongchun Liu6Qi Xue7Peng Yang8Department of General Surgery Southern Medical University Hospital of Integrated Traditional Chinese and Western Medicine Southern Medical University Guangdong 510315 ChinaXi'an Key Laboratory for Prevention and Treatment of Common Aging Diseases Translational and Research Centre for Prevention and Therapy of Chronic Disease Institute of Basic and Translational Medicine Xi'an Medical University Xi'an 710021 ChinaCollege of Pharmacy Xi'an Medical University Xi'an 710021 ChinaCollege of Clinical Medicine Xi'an Medical University Xi'an 710021 ChinaDepartment of General Surgery Southern Medical University Hospital of Integrated Traditional Chinese and Western Medicine Southern Medical University Guangdong 510315 ChinaDepartment of General Surgery Southern Medical University Hospital of Integrated Traditional Chinese and Western Medicine Southern Medical University Guangdong 510315 ChinaKey Laboratory of Applied Surface and Colloid Chemistry Ministry of Education School of Chemistry and Chemical Engineering Shaanxi Normal University Xi'an 710119 ChinaDepartment of General Surgery Southern Medical University Hospital of Integrated Traditional Chinese and Western Medicine Southern Medical University Guangdong 510315 ChinaKey Laboratory of Applied Surface and Colloid Chemistry Ministry of Education School of Chemistry and Chemical Engineering Shaanxi Normal University Xi'an 710119 ChinaColorectal cancer (CRC) has a postoperative recurrence rate of up to 50%. Local treatment at the surgical site offers a new strategy to prevent recurrence, minimizing systemic side effects. However, these treatments often face issues like poor stability, insufficient targeting, and significant local side effects. Research shows glucose starvation can induce disulfidptosis, a novel cell death pathway, in CRC cells, suitable for precise intervention in residual tumor cells postsurgery. This study develops a biocompatible 2D therapeutic platform using amyloid‐like protein nanofilm technology for precise local synergistic intervention in disulfidptosis and photodynamic therapy (PDT) after CRC surgery. The nanofilm boasts excellent drug‐loading capacity, enzyme activity retention, ultrathin dimensions, wet adhesion, and biocompatibility. A model simulating incomplete tumor resection post‐CRC surgery shows that the GCI@nanofilm effectively inhibits recurrence through an enzyme‐catalyzed cascade reaction inducing disulfidptosis and synergizing with PDT. In summary, GCI@nanofilm overcomes multiple challenges in local postsurgical intervention, providing a foundation for precise and efficient treatment of residual tumors.https://doi.org/10.1002/smsc.2024003232D protein filmcolorectal cancer recurrencedisulfidptosissynergismwet interface adhesion |
| spellingShingle | Man Zhang Ke Li Junhao Kou Guozhi Lu Ling Qiu Chunzhao Yang Yongchun Liu Qi Xue Peng Yang Functionalized Amyloid‐Like Protein Nanofilm‐Mediated Synergistic Disulfidptosis and Photodynamic Therapy for Preventing Postoperative Recurrence of Colorectal Cancer Small Science 2D protein film colorectal cancer recurrence disulfidptosis synergism wet interface adhesion |
| title | Functionalized Amyloid‐Like Protein Nanofilm‐Mediated Synergistic Disulfidptosis and Photodynamic Therapy for Preventing Postoperative Recurrence of Colorectal Cancer |
| title_full | Functionalized Amyloid‐Like Protein Nanofilm‐Mediated Synergistic Disulfidptosis and Photodynamic Therapy for Preventing Postoperative Recurrence of Colorectal Cancer |
| title_fullStr | Functionalized Amyloid‐Like Protein Nanofilm‐Mediated Synergistic Disulfidptosis and Photodynamic Therapy for Preventing Postoperative Recurrence of Colorectal Cancer |
| title_full_unstemmed | Functionalized Amyloid‐Like Protein Nanofilm‐Mediated Synergistic Disulfidptosis and Photodynamic Therapy for Preventing Postoperative Recurrence of Colorectal Cancer |
| title_short | Functionalized Amyloid‐Like Protein Nanofilm‐Mediated Synergistic Disulfidptosis and Photodynamic Therapy for Preventing Postoperative Recurrence of Colorectal Cancer |
| title_sort | functionalized amyloid like protein nanofilm mediated synergistic disulfidptosis and photodynamic therapy for preventing postoperative recurrence of colorectal cancer |
| topic | 2D protein film colorectal cancer recurrence disulfidptosis synergism wet interface adhesion |
| url | https://doi.org/10.1002/smsc.202400323 |
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