Discovery of a broad-spectrum monoclonal antibody recognizing a conserved, linear epitope WFYDGYPT on VP1 protein of Enterovirus A species

Discovery of a broad-spectrum monoclonal antibody recognizing a conserved, linear epitope WFYDGYPT on VP1 protein of Enterovirus A species

Abstract Background The hand, foot and mouth disease (HFMD) was caused by species of Enterovirus A and Enterovirus B in the Asian-Pacific region. Broad-spectrum monoclonal antibodies (mAb) that can bind multiple serotypes of enteroviruses have gradually become a research hotspot in the diagnosis, pr...

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Bibliographic Details
Main Authors: Lie Fu, Wei-Ping Jin, Wen-Hui Wang, Chen Wang, Sha-Sha Qian, Meng-Jun Wang, Rui-Lun Liu, Song-Zhuang Li, Ya-Xin Du, Sheng-Li Meng, Jing Guo, Ze-Jun Wang, Xiao-Qi Chen, Shuo Shen
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Virology Journal
Subjects:
Hand foot and mouth disease
Enterovirus A species
Broad-spectrum monoclonal antibody
Structural protein VP1
Epitope mapping
Online Access:https://doi.org/10.1186/s12985-024-02596-4
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