Role and interactions of organelle stress in septic cardiomyopathy
Septic cardiomyopathy (SCM) refers to the cardiac dysfunction induced by sepsis, a longstanding focus in clinical research. It usually presents as reversible myocardial dysfunction with a complex pathogenesis. The excessive inflammatory response, immune dysfunction, and dysregulation of homeostasis...
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| Format: | Article |
| Language: | zho |
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Lanzhou University Press
2024-12-01
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| Series: | 生物医学转化 |
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| Online Access: | http://swyxzh.ijournals.cn/swyxzh/article/html/20240401 |
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| author | Wei Wei Zhang Jinbo Zhang Zhaocai |
| author_facet | Wei Wei Zhang Jinbo Zhang Zhaocai |
| author_sort | Wei Wei |
| collection | DOAJ |
| description | Septic cardiomyopathy (SCM) refers to the cardiac dysfunction induced by sepsis, a longstanding focus in clinical research. It usually presents as reversible myocardial dysfunction with a complex pathogenesis. The excessive inflammatory response, immune dysfunction, and dysregulation of homeostasis induced by sepsis can trigger abnormal stress responses in organelles such as endoplasmic reticulum, mitochondria, and Golgi apparatus, regulating the pathophysiological progression of SCM. This article focuses on organelle stress responses, analyzing their roles and mechanisms in SCM. In addition, we further discuss the interactions between different organelle stress responses in the disease progression, providing a valuable reference for advancing the understanding of SCM and developing corresponding therapeutic strategies. |
| format | Article |
| id | doaj-art-31bf2466c47a4daaa5b69a0dabadd094 |
| institution | Kabale University |
| issn | 2096-8965 |
| language | zho |
| publishDate | 2024-12-01 |
| publisher | Lanzhou University Press |
| record_format | Article |
| series | 生物医学转化 |
| spelling | doaj-art-31bf2466c47a4daaa5b69a0dabadd0942025-01-13T08:01:54ZzhoLanzhou University Press生物医学转化2096-89652024-12-015421210.12287/j.issn.2096-8965.20240401Role and interactions of organelle stress in septic cardiomyopathyWei Wei0Zhang Jinbo1Zhang Zhaocai2The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009 , Zhejiang, China ；Affiliated Huzhou Hospital, Zhejiang University School of Medicine, Huzhou 313000 , Zhejiang, ChinaThe First Peoples Hospital of Wenling, Taizhou 317500 , Zhejiang, ChinaThe Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009 , Zhejiang, ChinaSeptic cardiomyopathy (SCM) refers to the cardiac dysfunction induced by sepsis, a longstanding focus in clinical research. It usually presents as reversible myocardial dysfunction with a complex pathogenesis. The excessive inflammatory response, immune dysfunction, and dysregulation of homeostasis induced by sepsis can trigger abnormal stress responses in organelles such as endoplasmic reticulum, mitochondria, and Golgi apparatus, regulating the pathophysiological progression of SCM. This article focuses on organelle stress responses, analyzing their roles and mechanisms in SCM. In addition, we further discuss the interactions between different organelle stress responses in the disease progression, providing a valuable reference for advancing the understanding of SCM and developing corresponding therapeutic strategies.http://swyxzh.ijournals.cn/swyxzh/article/html/20240401sepsisseptic myocardial injuryorganelle stress responsecrosstalk |
| spellingShingle | Wei Wei Zhang Jinbo Zhang Zhaocai Role and interactions of organelle stress in septic cardiomyopathy 生物医学转化 sepsis septic myocardial injury organelle stress response crosstalk |
| title | Role and interactions of organelle stress in septic cardiomyopathy |
| title_full | Role and interactions of organelle stress in septic cardiomyopathy |
| title_fullStr | Role and interactions of organelle stress in septic cardiomyopathy |
| title_full_unstemmed | Role and interactions of organelle stress in septic cardiomyopathy |
| title_short | Role and interactions of organelle stress in septic cardiomyopathy |
| title_sort | role and interactions of organelle stress in septic cardiomyopathy |
| topic | sepsis septic myocardial injury organelle stress response crosstalk |
| url | http://swyxzh.ijournals.cn/swyxzh/article/html/20240401 |
| work_keys_str_mv | AT weiwei roleandinteractionsoforganellestressinsepticcardiomyopathy AT zhangjinbo roleandinteractionsoforganellestressinsepticcardiomyopathy AT zhangzhaocai roleandinteractionsoforganellestressinsepticcardiomyopathy |