Innovative pan-tumor target strategy for CAR-T therapy: cancer-specific exons as novel targets for pediatric solid and brain tumors

Innovative pan-tumor target strategy for CAR-T therapy: cancer-specific exons as novel targets for pediatric solid and brain tumors

Abstract Chimeric antigen receptor T-cell (CAR-T) immunotherapy has achieved remarkable success in treating chemotherapy-refractory hematological malignancies. However, its efficacy in solid and brain tumors remains limited due to challenges such as insufficient target antigens, poor T-cell adaptabi...

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Bibliographic Details
Main Authors: Yuqing Luo, Jianqiao Shentu, Hening Xu, Yongming Xia, Lili Fang, Shiwei Duan
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Journal of Translational Medicine
Subjects:
CAR-T immunotherapy
Cancer-specific exons
Pediatric tumors
Solid tumors
Tumor microenvironment
Online Access:https://doi.org/10.1186/s12967-024-05861-w
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