Application and prospects of genetic engineering in CAR-NK cell therapy

Application and prospects of genetic engineering in CAR-NK cell therapy

With the rapid advancement of genetic engineering technologies, CAR-NK cell therapy, as an emerging immunotherapeutic approach, has demonstrated significant potential. CAR-NK cells recognize and eliminate tumor cells through chimeric antigen receptors (CARs). Genetic engineering techniques have enha...

Full description

Saved in:

Bibliographic Details
Main Authors:	Caidong Hu, Wenhong Lai, Bin Tian, Xi Xu, Shuiling Xie, Wenting Zhong, Huiqiang Kang, Xiaoyun Chen, Hailiang Li, Jingxin Xu, Liping Liu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-05-01
Series:	Frontiers in Immunology
Subjects:	natural killer cells CAR-NK cells genetic engineering NK cell expansion vectors for CAR expression tumor microenvironment
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1600411/full
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

NK cells expansion <i>in vitro</i> is followed by loss of inhibitory KIR expression
by: N. A. Alekseeva, et al.
Published: (2023-06-01)

Precision sniper for solid tumors: CAR-NK cell therapy
by: Sisi Li, et al.
Published: (2025-07-01)

PECULIARITIES OF NK CELLS DIFFERENTIATION: CD56dim AND CD56bright NK CELLS AT PREGNANCY AND IN NON-PREGNANT STATE
by: V. A. Mikhailova, et al.
Published: (2017-01-01)

Promising approach for targeting ROBO1 with CAR NK cells to combat ovarian cancer primary tumor cells and organoids
by: Yan Zhu, et al.
Published: (2024-12-01)

Transcriptomic and proteomic signatures of host NK cells delineate distinct immune states across tuberculosis infection statuses
by: Han Zhang, et al.
Published: (2025-06-01)

Targeting ATF5, CEBPB, and CEBPD with Cell-Penetrating Dpep Sensitizes Tumor Cells to NK-92MI Cell Cytotoxicity
by: Qing Zhou, et al.
Published: (2025-05-01)

The role of γδТ- and NK-сells in immune response
by: Ye. G. Churina, et al.
Published: (2010-10-01)

Comprehensive characterization of NK cell-related genes in cutaneous melanoma identified a novel prognostic signature for predicting the prognosis, immunotherapy, and chemotherapy efficacy
by: Haili Ma, et al.
Published: (2025-07-01)

Cell-targeted PD-1 agonists are potent NK-cell inhibitors
by: Harriet C. Pope, et al.
Published: (2025-08-01)

Chimeric Antigen Receptor (CAR)-NK92 cells effective against glioblastoma, breast- and pancreatic cancer in vitro and in a murine xenograft model of ovarian cancer
by: Abdelhadi Boulifa, et al.
Published: (2025-07-01)

Lower Number and Percentage of Activated Natural Killer Cells in Colorectal Cancer Patients
by: Amie Vidyani, et al.
Published: (2023-01-01)

A spreadable self-gelling hemostatic powder sensitizes CAR-NK cell therapy to prevent hepatocellular carcinoma recurrence postresection
by: Yusheng Cheng, et al.
Published: (2025-05-01)

Exosomes and immune modulation: implications for neuroblastoma immunotherapy
by: Martina Morini, et al.
Published: (2025-05-01)

Isolation andfunctional characterization of HO-hMSCs as NK-supportive cells derived from hematopoietic organoids
by: TANG Shili, et al.
Published: (2025-05-01)

The MICA‐129 dimorphism affects NKG2D signaling and outcome of hematopoietic stem cell transplantation
by: Antje Isernhagen, et al.
Published: (2015-10-01)

A high proportion of CD38 (high) CD16 (low) NK cells in colorectal cancer can interrupt immune surveillance and favor tumor growth
by: Xueling Wang, et al.
Published: (2025-07-01)

Case report of non-gene editing CD7 CAR T cell therapy in CD7+ Sézary syndrome: preclinical validation and first-in-human use
by: Haichan Xu, et al.
Published: (2025-08-01)

CD2-targeted nanoparticles encapsulating IL-2 induce tolerogenic Tregs and TGF-β-producing NK cells that stabilize Tregs for long-term therapeutic efficacy in immune-mediated disorders
by: David A. Horwitz, et al.
Published: (2025-07-01)

Unlocking Apoptotic Pathways: Overcoming Tumor Resistance in CAR‐T‐Cell Therapy
by: Zhanna Zhang, et al.
Published: (2024-10-01)

EFFECTS OF DEHYDROEPIANDROSTERONE SULFATE UPON PHENOTYPE AND IN VITRO FUNCTIONS OF DENDRITIC CELLS
by: N. V. Seledzova, et al.
Published: (2014-07-01)

Advances and obstacles of T cell-based immunotherapy in gynecological malignancies
by: Xi Zhao, et al.
Published: (2025-07-01)

Prognostic value of the ratio of red cell volume distribution width to absolute lymphocyte count in patients with extranodal NK/T-cell lymphoma
by: Tian-Zi XU, et al.
Published: (2023-12-01)

Editorial: Immune cell therapy approaches targeting tumor microenvironment
by: Santosh K. Patnaik, et al.
Published: (2025-05-01)

Cell-based medicinal products: a review of current research
by: E. V. Galitsyna, et al.
Published: (2024-12-01)

FEATURES OF NK-CELL CONTENTS IN PATIENTS WITH CHRONIC HEPATITIS C
by: M. S. Selkova, et al.
Published: (2014-07-01)

The Potential Use of Digital Twin Technology for Advancing CAR-T Cell Therapy
by: Sara Sadat Aghamiri, et al.
Published: (2025-04-01)

IMMUNE DYSFUNCTIONS IN WOMEN WITH INFERTILITY OF UNKNOWN ORIGIN
by: N. A. Khonina, et al.
Published: (2014-07-01)

Identification of hub biomarkers in coronary artery disease patients using machine learning and bioinformatic analyses
by: Xindi Chang, et al.
Published: (2025-05-01)

Research on strategies to inhibit CAR-T cell exhaustion
by: FU Qiongyu, HAO Xinbao, TAO Shi
Published: (2025-04-01)

Extranodal NK/T-cell lymphoma of nasal type with midline symmetry oral ulcer as the main symptom: A case report and literature review
by: YU Donglin, et al.
Published: (2025-04-01)

Cytokine release syndrome and CAR T Cell therapy: Modulating the intensity of the inflammatory response and resolution within the tumor microenvironment
by: David F. Driscoll, et al.
Published: (2025-06-01)

Extranodal NK/T-cell lymphoma: a review of literature and case report
by: N. G. Chernova, et al.
Published: (2016-10-01)

Expression features of CD16 and NKG2D receptors by NK cells, NKT cells and T lymphocytes of peripheral blood associated with female infertility
by: V. A. Mikhailova, et al.
Published: (2025-07-01)

iPSC-derived NK cells engineered with CD226 effectively control acute myeloid leukemia
by: Runze Cai, et al.
Published: (2025-07-01)

Arachidonic acid impairs natural killer cell functions by disrupting signaling pathways driven by activating receptors and reactive oxygen species
by: Mohamad K. Hammoud, et al.
Published: (2024-11-01)

Unusual Case of Midline Middle Skull Base Lymphoma Mimicking as Invasive Pituitary Adenoma
by: Harish Naik, et al.
Published: (2017-05-01)

Robo1 CAR-NK92 and radiotherapy exert synergistic efficacy in solid tumors
by: Mengdi Wu, et al.
Published: (2025-07-01)

SCAN-ACT: adoptive T cell therapy target discovery through single-cell transcriptomics
by: Stefano Testa, et al.
Published: (2025-08-01)

CHARACTERISTICS OF SIGNALING PATHWAYS MEDIATING A CYTOTOXIC EFFECT OF DENDRITIC CELLS UPON ACTIVATED Т LYMPHOCYTES AND NK CELLS
by: T. V. Tyrinova, et al.
Published: (2014-07-01)

M‐CSF directs myeloid and NK cell differentiation to protect from CMV after hematopoietic cell transplantation
by: Prashanth K Kandalla, et al.
Published: (2023-08-01)