The Role of Gut Microbiota in Neurodegenerative Diseases
Introduction: The gut microbiota is a key component of the gut-brain axis, and its dysbiosis promotes neuroinflammation. The microbiome plays a significant role in the pathogenesis of neurodegenerative diseases. This article focuses on Alzheimer's and Parkinson's diseases. Materials an...
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| Format: | Article |
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Kazimierz Wielki University
2025-01-01
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| Series: | Journal of Education, Health and Sport |
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| Online Access: | https://apcz.umk.pl/JEHS/article/view/56676 |
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| author | Hanna Porwolik Agnieszka Porwolik Magdalena Bodera Radosław Szydłowski Agata Porwolik Barbara Skrzypiec Anna Hamerla Anna Kaźmierska Julia Gawron |
| author_facet | Hanna Porwolik Agnieszka Porwolik Magdalena Bodera Radosław Szydłowski Agata Porwolik Barbara Skrzypiec Anna Hamerla Anna Kaźmierska Julia Gawron |
| author_sort | Hanna Porwolik |
| collection | DOAJ |
| description |
Introduction: The gut microbiota is a key component of the gut-brain axis, and its dysbiosis promotes neuroinflammation. The microbiome plays a significant role in the pathogenesis of neurodegenerative diseases. This article focuses on Alzheimer's and Parkinson's diseases.
Materials and methods: PubMed and Google Scholar databases were searched using the keywords: "gut microbiota," "neurodegenerative diseases," "probiotics," and "fecal microbiota transplantation." A selection of relevant materials was then analyzed.
Aim of the study: The aim of this study is to investigate the impact of the gut microbiota on the development of neurodegenerative diseases, with a particular focus on Parkinson's and Alzheimer's, and to explore the possibility of slowing their progression or improving their treatment by subjecting the microbiota to change.
Description of the state of knowledge: Targeting the gut microbiota represents a novel avenue for managing NDDs. Therapeutic strategies focusing on microbiota modulation, including probiotics and FMT, show significant potential. Further research is essential to validate these approaches and optimize personalized treatments for AD and PD.
Results: Gut microbiota dysbiosis was found to significantly contribute to the progression of AD and PD diseases by promoting neuroinflammation, disrupting the blood-brain barrier, and altering neurotransmitter levels. Probiotics, particularly Lactobacillus and Bifidobacterium strains and FMT showed potential in restoring microbial balance and reducing inflammation and improved cognitive and motor functions. Despite these promising findings, clinical evidence remains limited, and further research is necessary.
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| format | Article |
| id | doaj-art-31b008abd6e341b8b862fd014e6ec0d6 |
| institution | Kabale University |
| issn | 2391-8306 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Kazimierz Wielki University |
| record_format | Article |
| series | Journal of Education, Health and Sport |
| spelling | doaj-art-31b008abd6e341b8b862fd014e6ec0d62025-01-11T08:16:45ZengKazimierz Wielki UniversityJournal of Education, Health and Sport2391-83062025-01-017710.12775/JEHS.2025.77.56676The Role of Gut Microbiota in Neurodegenerative DiseasesHanna Porwolik0https://orcid.org/0009-0001-5004-3725Agnieszka Porwolik1https://orcid.org/0009-0007-9667-5676Magdalena Bodera2https://orcid.org/0009-0002-8890-214XRadosław Szydłowski3https://orcid.org/0009-0000-5771-3990Agata Porwolik4https://orcid.org/0009-0003-5533-5377Barbara Skrzypiec5https://orcid.org/0009-0005-1961-6627Anna Hamerla6https://orcid.org/0009-0006-4001-0256Anna Kaźmierska7https://orcid.org/0009-0005-2625-6260Julia Gawron8https://orcid.org/0009-0009-5869-7377Professor Zbigniew Religa Student Scientific Association at the Department of Biophysics, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Jordana 19, 41-808 Zabrze, PolandSilesia Orthodontics, Juliusza Słowackiego 13, 40-094 Katowice, PolandProfessor Zbigniew Religa Student Scientific Association at the Department of Biophysics, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Jordana 19, 41-808 Zabrze, PolandProfessor Zbigniew Religa Student Scientific Association at the Department of Biophysics, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Jordana 19, 41-808 Zabrze, PolandProfessor Zbigniew Religa Student Scientific Association at the Department of Biophysics, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Jordana 19, 41-808 Zabrze, PolandMedical University of Silesia in Katowice, Józefa Poniatowskiego 15, 40–055 Katowice, PolandMedical University of Silesia in Katowice, Józefa Poniatowskiego 15, 40–055 Katowice, PolandProfessor Zbigniew Religa Student Scientific Association at the Department of Biophysics, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Jordana 19, 41-808 Zabrze, PolandProfessor Zbigniew Religa Student Scientific Association at the Department of Biophysics, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Jordana 19, 41-808 Zabrze, PolandProfessor Zbigniew Religa Student Scientific Association at the Department of Biophysics, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Jordana 19, 41-808 Zabrze, Poland Introduction: The gut microbiota is a key component of the gut-brain axis, and its dysbiosis promotes neuroinflammation. The microbiome plays a significant role in the pathogenesis of neurodegenerative diseases. This article focuses on Alzheimer's and Parkinson's diseases. Materials and methods: PubMed and Google Scholar databases were searched using the keywords: "gut microbiota," "neurodegenerative diseases," "probiotics," and "fecal microbiota transplantation." A selection of relevant materials was then analyzed. Aim of the study: The aim of this study is to investigate the impact of the gut microbiota on the development of neurodegenerative diseases, with a particular focus on Parkinson's and Alzheimer's, and to explore the possibility of slowing their progression or improving their treatment by subjecting the microbiota to change. Description of the state of knowledge: Targeting the gut microbiota represents a novel avenue for managing NDDs. Therapeutic strategies focusing on microbiota modulation, including probiotics and FMT, show significant potential. Further research is essential to validate these approaches and optimize personalized treatments for AD and PD. Results: Gut microbiota dysbiosis was found to significantly contribute to the progression of AD and PD diseases by promoting neuroinflammation, disrupting the blood-brain barrier, and altering neurotransmitter levels. Probiotics, particularly Lactobacillus and Bifidobacterium strains and FMT showed potential in restoring microbial balance and reducing inflammation and improved cognitive and motor functions. Despite these promising findings, clinical evidence remains limited, and further research is necessary. https://apcz.umk.pl/JEHS/article/view/56676gut microbiotaneurodegenerative diseasesprobioticsfecal microbiota transplantation |
| spellingShingle | Hanna Porwolik Agnieszka Porwolik Magdalena Bodera Radosław Szydłowski Agata Porwolik Barbara Skrzypiec Anna Hamerla Anna Kaźmierska Julia Gawron The Role of Gut Microbiota in Neurodegenerative Diseases Journal of Education, Health and Sport gut microbiota neurodegenerative diseases probiotics fecal microbiota transplantation |
| title | The Role of Gut Microbiota in Neurodegenerative Diseases |
| title_full | The Role of Gut Microbiota in Neurodegenerative Diseases |
| title_fullStr | The Role of Gut Microbiota in Neurodegenerative Diseases |
| title_full_unstemmed | The Role of Gut Microbiota in Neurodegenerative Diseases |
| title_short | The Role of Gut Microbiota in Neurodegenerative Diseases |
| title_sort | role of gut microbiota in neurodegenerative diseases |
| topic | gut microbiota neurodegenerative diseases probiotics fecal microbiota transplantation |
| url | https://apcz.umk.pl/JEHS/article/view/56676 |
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