The effects of coenzyme q10 on testes of rats with diabetes induced by streptozotocin
<b>Aim:</b> In this study, it was aimed to determine the effect of CoQ<sub>10</sub> on testes in streptozotocin (STZ) induced diabetic rats.<p> <b>Materials and Methods: </b>In this study, thirty-four adult male Wistar Albino rats were used. The animals were...
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| Language: | English |
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Selcuk University Press
2021-12-01
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| Series: | Eurasian Journal of Veterinary Sciences |
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| Online Access: | http://eurasianjvetsci.org/pdf.php3?id=1369 |
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| author | Tuğba Özaydın Yasemin Öznurlu Emrah Sur |
| author_facet | Tuğba Özaydın Yasemin Öznurlu Emrah Sur |
| author_sort | Tuğba Özaydın |
| collection | DOAJ |
| description | <b>Aim:</b> In this study, it was aimed to determine the effect of CoQ<sub>10</sub> on testes
in streptozotocin (STZ) induced diabetic rats.<p>
<b>Materials and Methods: </b>In this study, thirty-four adult male Wistar Albino
rats were used. The animals were divided into five groups: Control
group (K), oil group (Y; daily intraperitoneal injection of 0,3 ml corn oil),
CoQ<sub>10</sub> group (CoQ<sub>10</sub>; daily intraperitoneal injection of 10 mg/kg CoQ<sub>10</sub>), Diabetes
group (D; subcutan injection of 40 mg/kg STZ, single daily dose for
two days), and Diabetes+ CoQ<sub>10</sub> group (D+CoQ<sub>10</sub>; Diabetic rats was injected
daily intraperitoneally 10 mg/kg CoQ<sub>10</sub>). At the end of fourth week, tissue
samples were obtained from sacrified animals. Testes were weighed, then
fixed in Bouin's solution and processed by means of routine histological
techniques. Sections were stained with H&E staining method to determine
the general histological structure. Also, PCNA reactivity was determined
by immunohistochemical method.<p>
<b>Results: </b>The mean body weight was significantly decreased in diabetes
and diabetes+ CoQ<sub>10</sub> groups when compared to control, oil and CoQ<sub>10</sub>
groups but the gonadosomatic index (GSI) was found higher in diabetes
groups (p<0.05). Mean seminiferous tubular diameter (STD), height of
germinal epithelium (GEH) and PCNA index were significantly reduced in
diabetes groups in comparison with control, oil, CoQ<sub>10</sub> and diabetes+CoQ<sub>10</sub>
groups (p<0.05). In diabetes+CoQ<sub>10</sub> group showed significantly increase in
STD, GEH and PCNA index compared to diabetes group (p<0.05).<p>
<b>Conclusion: </b>In conclusion, CoQ<sub>10</sub> play a role in reducing the cellular damages
caused by diabetes. |
| format | Article |
| id | doaj-art-31aadcde6d7845b68a9b7bc66a2c620c |
| institution | Kabale University |
| issn | 1309-6958 2146-1953 |
| language | English |
| publishDate | 2021-12-01 |
| publisher | Selcuk University Press |
| record_format | Article |
| series | Eurasian Journal of Veterinary Sciences |
| spelling | doaj-art-31aadcde6d7845b68a9b7bc66a2c620c2025-01-03T01:37:30ZengSelcuk University PressEurasian Journal of Veterinary Sciences1309-69582146-19532021-12-013742352421369The effects of coenzyme q10 on testes of rats with diabetes induced by streptozotocinTuğba Özaydın0Yasemin Öznurlu1Emrah Sur2Selçuk Üniversitesi Veteriner Fakültesi Histoloji ve Embriyoloji Anabilim Dalı, Konya, TürkiyeSelçuk Üniversitesi Veteriner Fakültesi Histoloji ve Embriyoloji Anabilim Dalı, Konya, TürkiyeSelçuk Üniversitesi Veteriner Fakültesi Histoloji ve Embriyoloji Anabilim Dalı, Konya, Türkiye<b>Aim:</b> In this study, it was aimed to determine the effect of CoQ<sub>10</sub> on testes in streptozotocin (STZ) induced diabetic rats.<p> <b>Materials and Methods: </b>In this study, thirty-four adult male Wistar Albino rats were used. The animals were divided into five groups: Control group (K), oil group (Y; daily intraperitoneal injection of 0,3 ml corn oil), CoQ<sub>10</sub> group (CoQ<sub>10</sub>; daily intraperitoneal injection of 10 mg/kg CoQ<sub>10</sub>), Diabetes group (D; subcutan injection of 40 mg/kg STZ, single daily dose for two days), and Diabetes+ CoQ<sub>10</sub> group (D+CoQ<sub>10</sub>; Diabetic rats was injected daily intraperitoneally 10 mg/kg CoQ<sub>10</sub>). At the end of fourth week, tissue samples were obtained from sacrified animals. Testes were weighed, then fixed in Bouin's solution and processed by means of routine histological techniques. Sections were stained with H&E staining method to determine the general histological structure. Also, PCNA reactivity was determined by immunohistochemical method.<p> <b>Results: </b>The mean body weight was significantly decreased in diabetes and diabetes+ CoQ<sub>10</sub> groups when compared to control, oil and CoQ<sub>10</sub> groups but the gonadosomatic index (GSI) was found higher in diabetes groups (p<0.05). Mean seminiferous tubular diameter (STD), height of germinal epithelium (GEH) and PCNA index were significantly reduced in diabetes groups in comparison with control, oil, CoQ<sub>10</sub> and diabetes+CoQ<sub>10</sub> groups (p<0.05). In diabetes+CoQ<sub>10</sub> group showed significantly increase in STD, GEH and PCNA index compared to diabetes group (p<0.05).<p> <b>Conclusion: </b>In conclusion, CoQ<sub>10</sub> play a role in reducing the cellular damages caused by diabetes.http://eurasianjvetsci.org/pdf.php3?id=1369coq<sub>10</sub>diabetespcnarattestes |
| spellingShingle | Tuğba Özaydın Yasemin Öznurlu Emrah Sur The effects of coenzyme q10 on testes of rats with diabetes induced by streptozotocin Eurasian Journal of Veterinary Sciences coq<sub>10</sub> diabetes pcna rat testes |
| title | The effects of coenzyme q10 on testes of rats with diabetes induced by streptozotocin |
| title_full | The effects of coenzyme q10 on testes of rats with diabetes induced by streptozotocin |
| title_fullStr | The effects of coenzyme q10 on testes of rats with diabetes induced by streptozotocin |
| title_full_unstemmed | The effects of coenzyme q10 on testes of rats with diabetes induced by streptozotocin |
| title_short | The effects of coenzyme q10 on testes of rats with diabetes induced by streptozotocin |
| title_sort | effects of coenzyme q10 on testes of rats with diabetes induced by streptozotocin |
| topic | coq<sub>10</sub> diabetes pcna rat testes |
| url | http://eurasianjvetsci.org/pdf.php3?id=1369 |
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