Bone measurements interact with phenotypic measures in canine Duchenne muscular dystrophy
Duchenne muscular dystrophy (DMD) is an X-linked muscle disease with weakness, loss of ambulation, and premature death. DMD patients have reduced bone health, including decreased femur length (FL), density, and fractures. The mdx mouse model has paradoxically greater FL, density, and strength, posit...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Veterinary Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2024.1339833/full |
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| author | Sarah M. Schneider Macie L. Mackey Savannah Wilkinson Lee-Jae Guo Peter P. Nghiem |
| author_facet | Sarah M. Schneider Macie L. Mackey Savannah Wilkinson Lee-Jae Guo Peter P. Nghiem |
| author_sort | Sarah M. Schneider |
| collection | DOAJ |
| description | Duchenne muscular dystrophy (DMD) is an X-linked muscle disease with weakness, loss of ambulation, and premature death. DMD patients have reduced bone health, including decreased femur length (FL), density, and fractures. The mdx mouse model has paradoxically greater FL, density, and strength, positively correlating with muscle mass. Bone morphology has not been extensively studied in the genetic homolog, golden retriever muscular dystrophy (GRMD). The aim of this study was to compare bone and muscle characteristics in GRMD dogs to understand their relationship to muscle function and density. We hypothesized that GRMD bone measurements would be altered similarly to DMD and would correlate with muscle strength and density. Eighteen variably aged and mixed gender dogs (6 each dystrophic, carrier, normal) were studied by computed tomography (CT) and bone measures were compared with various muscle functional measurements. FL, density, and volume and muscle density of several pelvic limb muscles were assessed. Dystrophic dogs showed some boney and muscle density changes on CT analysis compared to carriers and normal dogs. In GRMD, bone measurements were highly correlated with several other functional outcome measures, including eccentric contraction decrement, hip joint angle, and muscle volume/density. This novel experiment demonstrates an impact of dystrophy on bone outcome measures and provides observations on their correlation with functional outcomes. |
| format | Article |
| id | doaj-art-3197a5c1d8884207be4a2a0b85ba5dd4 |
| institution | Kabale University |
| issn | 2297-1769 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Veterinary Science |
| spelling | doaj-art-3197a5c1d8884207be4a2a0b85ba5dd42025-01-06T07:32:06ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692025-01-011110.3389/fvets.2024.13398331339833Bone measurements interact with phenotypic measures in canine Duchenne muscular dystrophySarah M. Schneider0Macie L. Mackey1Savannah Wilkinson2Lee-Jae Guo3Peter P. Nghiem4College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, United StatesDepartment of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX, United StatesCollege of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, United StatesDepartment of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX, United StatesDepartment of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX, United StatesDuchenne muscular dystrophy (DMD) is an X-linked muscle disease with weakness, loss of ambulation, and premature death. DMD patients have reduced bone health, including decreased femur length (FL), density, and fractures. The mdx mouse model has paradoxically greater FL, density, and strength, positively correlating with muscle mass. Bone morphology has not been extensively studied in the genetic homolog, golden retriever muscular dystrophy (GRMD). The aim of this study was to compare bone and muscle characteristics in GRMD dogs to understand their relationship to muscle function and density. We hypothesized that GRMD bone measurements would be altered similarly to DMD and would correlate with muscle strength and density. Eighteen variably aged and mixed gender dogs (6 each dystrophic, carrier, normal) were studied by computed tomography (CT) and bone measures were compared with various muscle functional measurements. FL, density, and volume and muscle density of several pelvic limb muscles were assessed. Dystrophic dogs showed some boney and muscle density changes on CT analysis compared to carriers and normal dogs. In GRMD, bone measurements were highly correlated with several other functional outcome measures, including eccentric contraction decrement, hip joint angle, and muscle volume/density. This novel experiment demonstrates an impact of dystrophy on bone outcome measures and provides observations on their correlation with functional outcomes.https://www.frontiersin.org/articles/10.3389/fvets.2024.1339833/fullDuchenne muscular dystrophygolden retriever muscular dystrophyGRMDcomputed tomographybonemuscle |
| spellingShingle | Sarah M. Schneider Macie L. Mackey Savannah Wilkinson Lee-Jae Guo Peter P. Nghiem Bone measurements interact with phenotypic measures in canine Duchenne muscular dystrophy Frontiers in Veterinary Science Duchenne muscular dystrophy golden retriever muscular dystrophy GRMD computed tomography bone muscle |
| title | Bone measurements interact with phenotypic measures in canine Duchenne muscular dystrophy |
| title_full | Bone measurements interact with phenotypic measures in canine Duchenne muscular dystrophy |
| title_fullStr | Bone measurements interact with phenotypic measures in canine Duchenne muscular dystrophy |
| title_full_unstemmed | Bone measurements interact with phenotypic measures in canine Duchenne muscular dystrophy |
| title_short | Bone measurements interact with phenotypic measures in canine Duchenne muscular dystrophy |
| title_sort | bone measurements interact with phenotypic measures in canine duchenne muscular dystrophy |
| topic | Duchenne muscular dystrophy golden retriever muscular dystrophy GRMD computed tomography bone muscle |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2024.1339833/full |
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