Prevalence of peripheral neuropathy in children with transfusion-dependent thalassemia: A hospital-based cross-sectional study
Background: Our study aimed to determine the prevalence of Peripheral Neuropathy (using nerve conduction studies (NCS)) in children with transfusion-dependent thalassemia aged between 5 to 18 years and to study its correlation with chronic anemia, ferritin levels, chelation status, annual transfusio...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2024-12-01
|
| Series: | Journal of Family Medicine and Primary Care |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/jfmpc.jfmpc_289_24 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841545807568830464 |
|---|---|
| author | Aniruddha Rathore Mukesh Dhankar Sharmila B. Mukherjee Suvasini Sharma Shailaja Shukla Piali Mandal |
| author_facet | Aniruddha Rathore Mukesh Dhankar Sharmila B. Mukherjee Suvasini Sharma Shailaja Shukla Piali Mandal |
| author_sort | Aniruddha Rathore |
| collection | DOAJ |
| description | Background:
Our study aimed to determine the prevalence of Peripheral Neuropathy (using nerve conduction studies (NCS)) in children with transfusion-dependent thalassemia aged between 5 to 18 years and to study its correlation with chronic anemia, ferritin levels, chelation status, annual transfusion requirement, deficiency of serum Vitamin B12, and Folate levels.
Methods:
In this hospital-based cross-sectional study, 100 eligible children were enrolled in a tertiary care teaching hospital in New Delhi, India. Neurological examinations focusing on peripheral neuropathy followed by NCS were performed on all the patients. Age-wise cutoff values outside of 2.5 SD of normal were taken as abnormal.
Results:
None of the children had clinical features of peripheral neuropathy, although 77% had abnormalities in NCS. Of these, 33% had pure motor nerve changes, 7% had pure sensory nerve changes, 1% had abnormal F responses, and 26% had mixed nerve changes. These changes correlated significantly with chronic anemia and duration of iron chelation but not with other factors.
Conclusion:
In children with transfusion-dependent thalassemia who do not exhibit any neurological signs or symptoms, however, it is not uncommon to observe abnormal NCS at an average hemoglobin (Hb) level of less than 9.5 g/dl. Further comprehensive case-control studies are necessary to determine if a more specific Hb target range of 9.5 to 10.5 g/dl is appropriate and to investigate the potential impact of chelation therapy on these changes. |
| format | Article |
| id | doaj-art-316bcc63582d46e6b8c2341e8a502085 |
| institution | Kabale University |
| issn | 2249-4863 2278-7135 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Family Medicine and Primary Care |
| spelling | doaj-art-316bcc63582d46e6b8c2341e8a5020852025-01-11T10:11:09ZengWolters Kluwer Medknow PublicationsJournal of Family Medicine and Primary Care2249-48632278-71352024-12-0113125847585210.4103/jfmpc.jfmpc_289_24Prevalence of peripheral neuropathy in children with transfusion-dependent thalassemia: A hospital-based cross-sectional studyAniruddha RathoreMukesh DhankarSharmila B. MukherjeeSuvasini SharmaShailaja ShuklaPiali MandalBackground: Our study aimed to determine the prevalence of Peripheral Neuropathy (using nerve conduction studies (NCS)) in children with transfusion-dependent thalassemia aged between 5 to 18 years and to study its correlation with chronic anemia, ferritin levels, chelation status, annual transfusion requirement, deficiency of serum Vitamin B12, and Folate levels. Methods: In this hospital-based cross-sectional study, 100 eligible children were enrolled in a tertiary care teaching hospital in New Delhi, India. Neurological examinations focusing on peripheral neuropathy followed by NCS were performed on all the patients. Age-wise cutoff values outside of 2.5 SD of normal were taken as abnormal. Results: None of the children had clinical features of peripheral neuropathy, although 77% had abnormalities in NCS. Of these, 33% had pure motor nerve changes, 7% had pure sensory nerve changes, 1% had abnormal F responses, and 26% had mixed nerve changes. These changes correlated significantly with chronic anemia and duration of iron chelation but not with other factors. Conclusion: In children with transfusion-dependent thalassemia who do not exhibit any neurological signs or symptoms, however, it is not uncommon to observe abnormal NCS at an average hemoglobin (Hb) level of less than 9.5 g/dl. Further comprehensive case-control studies are necessary to determine if a more specific Hb target range of 9.5 to 10.5 g/dl is appropriate and to investigate the potential impact of chelation therapy on these changes.https://journals.lww.com/10.4103/jfmpc.jfmpc_289_24anaemiaperipheral neuropathytransufuison dependent thalaseemia |
| spellingShingle | Aniruddha Rathore Mukesh Dhankar Sharmila B. Mukherjee Suvasini Sharma Shailaja Shukla Piali Mandal Prevalence of peripheral neuropathy in children with transfusion-dependent thalassemia: A hospital-based cross-sectional study Journal of Family Medicine and Primary Care anaemia peripheral neuropathy transufuison dependent thalaseemia |
| title | Prevalence of peripheral neuropathy in children with transfusion-dependent thalassemia: A hospital-based cross-sectional study |
| title_full | Prevalence of peripheral neuropathy in children with transfusion-dependent thalassemia: A hospital-based cross-sectional study |
| title_fullStr | Prevalence of peripheral neuropathy in children with transfusion-dependent thalassemia: A hospital-based cross-sectional study |
| title_full_unstemmed | Prevalence of peripheral neuropathy in children with transfusion-dependent thalassemia: A hospital-based cross-sectional study |
| title_short | Prevalence of peripheral neuropathy in children with transfusion-dependent thalassemia: A hospital-based cross-sectional study |
| title_sort | prevalence of peripheral neuropathy in children with transfusion dependent thalassemia a hospital based cross sectional study |
| topic | anaemia peripheral neuropathy transufuison dependent thalaseemia |
| url | https://journals.lww.com/10.4103/jfmpc.jfmpc_289_24 |
| work_keys_str_mv | AT aniruddharathore prevalenceofperipheralneuropathyinchildrenwithtransfusiondependentthalassemiaahospitalbasedcrosssectionalstudy AT mukeshdhankar prevalenceofperipheralneuropathyinchildrenwithtransfusiondependentthalassemiaahospitalbasedcrosssectionalstudy AT sharmilabmukherjee prevalenceofperipheralneuropathyinchildrenwithtransfusiondependentthalassemiaahospitalbasedcrosssectionalstudy AT suvasinisharma prevalenceofperipheralneuropathyinchildrenwithtransfusiondependentthalassemiaahospitalbasedcrosssectionalstudy AT shailajashukla prevalenceofperipheralneuropathyinchildrenwithtransfusiondependentthalassemiaahospitalbasedcrosssectionalstudy AT pialimandal prevalenceofperipheralneuropathyinchildrenwithtransfusiondependentthalassemiaahospitalbasedcrosssectionalstudy |