Optical quality changes of the eye during peak SARS-CoV-2 pandemic in young adults
Introduction: To determine whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection affects corneal morphology and optical quality. Methods: In this cross-sectional study, ophthalmological indicators were examined during the peak of SARS-CoV-2 infection after adjusting for publ...
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Elsevier
2024-12-01
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| author | He Tian Qian Fan Wenjing Gao Yan Wang |
| author_facet | He Tian Qian Fan Wenjing Gao Yan Wang |
| author_sort | He Tian |
| collection | DOAJ |
| description | Introduction: To determine whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection affects corneal morphology and optical quality. Methods: In this cross-sectional study, ophthalmological indicators were examined during the peak of SARS-CoV-2 infection after adjusting for public health control measures. Participants were divided into control (remained uninfected), A (infected during follow-up), and B (infected prior to the first consultation) groups. Effects of varying SARS-CoV-2 infection levels were determined using reverse transcription polymerase chain reaction. Changes in corneal morphology, backscatter, and aberrations were measured. Corneal parameters, such as flat keratometry, steep keratometry, and surface variance, vertical asymmetry, height asymmetry, and height decentration indices were considered. Results: Overall, 110 participants (208 eyes, 42.7 % male; age 17–31 years) were enrolled. Eighteen (16.3 %) were infection-free during the outbreak with unchanged corneal morphology, backscatter, and aberration. In group A, 34.73 ± 9.30 days after infection, the backscatter of the anterior corneal layer and central layer (both p = 0.000) decreased. Total low-order aberration, defocus, horizontal coma, and spherical aberration of the cornea increased (p < 0.05), while corneal morphology after infection did not change (p > 0.05). In group B, a decrease in backscattering in the corneal middle layer and an increase in horizontal coma (p < 0.05) were noted. Conclusion: Backscattering of the anterior and intermediate layers of the cornea decreased and corneal aberrations increased after SARS-CoV-2 infection, which affected corneal optical quality. However, corneal morphology and thickness remained unchanged. Ophthalmological indicators and optical quality should be monitored during SARS-CoV-2 infection. |
| format | Article |
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| institution | Kabale University |
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| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
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| spelling | doaj-art-314b6e7a51dd46dea62cfe90781f519d2024-12-13T10:58:22ZengElsevierHeliyon2405-84402024-12-011023e39497Optical quality changes of the eye during peak SARS-CoV-2 pandemic in young adultsHe Tian0Qian Fan1Wenjing Gao2Yan Wang3Clinical College of Ophthalmology, Tianjin Medical University, Tianjin, China; Nankai University Eye Institute, Nankai University Affiliated Eye Hospital, Nankai University, Tianjin, China; Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin Eye Institute, Tianjin Eye Hospital, Tianjin, ChinaClinical College of Ophthalmology, Tianjin Medical University, Tianjin, China; Nankai University Eye Institute, Nankai University Affiliated Eye Hospital, Nankai University, Tianjin, China; Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin Eye Institute, Tianjin Eye Hospital, Tianjin, ChinaBeijing Friendship Hospital, Capital Medical University, Beijing, ChinaClinical College of Ophthalmology, Tianjin Medical University, Tianjin, China; Nankai University Eye Institute, Nankai University Affiliated Eye Hospital, Nankai University, Tianjin, China; Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin Eye Institute, Tianjin Eye Hospital, Tianjin, China; Corresponding author. Tianjin Key Laboratory of Ophthalmology and Visual Science, Tianjin Eye Institute, Tianjin Eye Hospital, No 4. Gansu Road, He-ping District, Tianjin, China, 300020.Introduction: To determine whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection affects corneal morphology and optical quality. Methods: In this cross-sectional study, ophthalmological indicators were examined during the peak of SARS-CoV-2 infection after adjusting for public health control measures. Participants were divided into control (remained uninfected), A (infected during follow-up), and B (infected prior to the first consultation) groups. Effects of varying SARS-CoV-2 infection levels were determined using reverse transcription polymerase chain reaction. Changes in corneal morphology, backscatter, and aberrations were measured. Corneal parameters, such as flat keratometry, steep keratometry, and surface variance, vertical asymmetry, height asymmetry, and height decentration indices were considered. Results: Overall, 110 participants (208 eyes, 42.7 % male; age 17–31 years) were enrolled. Eighteen (16.3 %) were infection-free during the outbreak with unchanged corneal morphology, backscatter, and aberration. In group A, 34.73 ± 9.30 days after infection, the backscatter of the anterior corneal layer and central layer (both p = 0.000) decreased. Total low-order aberration, defocus, horizontal coma, and spherical aberration of the cornea increased (p < 0.05), while corneal morphology after infection did not change (p > 0.05). In group B, a decrease in backscattering in the corneal middle layer and an increase in horizontal coma (p < 0.05) were noted. Conclusion: Backscattering of the anterior and intermediate layers of the cornea decreased and corneal aberrations increased after SARS-CoV-2 infection, which affected corneal optical quality. However, corneal morphology and thickness remained unchanged. Ophthalmological indicators and optical quality should be monitored during SARS-CoV-2 infection.http://www.sciencedirect.com/science/article/pii/S2405844024155284Corneal morphologyCoronavirusBackscatterCorneal aberrationOptical quality |
| spellingShingle | He Tian Qian Fan Wenjing Gao Yan Wang Optical quality changes of the eye during peak SARS-CoV-2 pandemic in young adults Heliyon Corneal morphology Coronavirus Backscatter Corneal aberration Optical quality |
| title | Optical quality changes of the eye during peak SARS-CoV-2 pandemic in young adults |
| title_full | Optical quality changes of the eye during peak SARS-CoV-2 pandemic in young adults |
| title_fullStr | Optical quality changes of the eye during peak SARS-CoV-2 pandemic in young adults |
| title_full_unstemmed | Optical quality changes of the eye during peak SARS-CoV-2 pandemic in young adults |
| title_short | Optical quality changes of the eye during peak SARS-CoV-2 pandemic in young adults |
| title_sort | optical quality changes of the eye during peak sars cov 2 pandemic in young adults |
| topic | Corneal morphology Coronavirus Backscatter Corneal aberration Optical quality |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024155284 |
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