Urinary mycoestrogens and gestational weight gain in the UPSIDE pregnancy cohort
Abstract Background Zearalenone (ZEN), a secondary metabolite of Fusarium fungi, is one of the most common mycotoxins in global food supplies such as cereal grains and processed food. ZEN and its metabolites are commonly referred to as mycoestrogens, due to their ability to directly bind nuclear est...
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2024-11-01
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| Online Access: | https://doi.org/10.1186/s12940-024-01141-8 |
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| author | Carolyn W. Kinkade Zorimar Rivera-Núñez Anita Brinker Brian Buckley Olivia Waysack Amber Kautz Ying Meng Pamela Ohman Strickland Robert Block Susan W. Groth Thomas G. O’Connor Lauren M. Aleksunes Emily S. Barrett |
| author_facet | Carolyn W. Kinkade Zorimar Rivera-Núñez Anita Brinker Brian Buckley Olivia Waysack Amber Kautz Ying Meng Pamela Ohman Strickland Robert Block Susan W. Groth Thomas G. O’Connor Lauren M. Aleksunes Emily S. Barrett |
| author_sort | Carolyn W. Kinkade |
| collection | DOAJ |
| description | Abstract Background Zearalenone (ZEN), a secondary metabolite of Fusarium fungi, is one of the most common mycotoxins in global food supplies such as cereal grains and processed food. ZEN and its metabolites are commonly referred to as mycoestrogens, due to their ability to directly bind nuclear estrogen receptors α (ER-α) and β (ER-β). Zeranol, a synthetic mycoestrogen, is administered to U.S. cattle as a growth promoter. Despite widespread human exposure and ample evidence of adverse reproductive impacts in vitro and in vivo, there has been little epidemiological research on the health impacts of ZEN exposure during pregnancy. The objective of our study was to examine associations between ZEN and gestational weight gain (GWG). Methods Urine samples were collected in each trimester from pregnant participants in the UPSIDE cohort (n = 286, Rochester, NY, USA). High performance liquid chromatography and high-resolution tandem mass spectrometry were used to quantify concentrations of ZEN as well as ∑mycoestrogens (composite sum of ZEN metabolites; ng/ml). Maternal weights at clinical visits were abstracted from medical records. We fitted longitudinal models of specific-gravity adjusted, log-transformed ZEN and ∑mycoestrogens in relation to total GWG (kilograms) and GWG rate (kilograms/week). We additionally examined risk of excessive GWG (in relation to Institute of Medicine guidelines) and considered effect modification by fetal sex. Results ZEN and ∑mycoestrogens were detected in > 93% and > 95% of samples, respectively. Mycoestrogen concentrations were positively associated with total GWG (ZEN β:0.50 kg; 95%CI: 0.13, 0.87) and GWG rate (ZEN β:0.20 kg/week; 95%CI: 0.01, 0.03). Associations tended to be stronger among participants carrying male (versus female) fetuses and results were robust to adjustment for diet. Conclusions Mycoestrogen exposure during pregnancy may contribute to greater GWG. Future research is needed to understand potential influences on downstream maternal and offspring health. |
| format | Article |
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| institution | Kabale University |
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| spelling | doaj-art-313f34ae1ca24c8b98c4aa9092e721c02024-11-24T12:41:49ZengBMCEnvironmental Health1476-069X2024-11-0123111210.1186/s12940-024-01141-8Urinary mycoestrogens and gestational weight gain in the UPSIDE pregnancy cohortCarolyn W. Kinkade0Zorimar Rivera-Núñez1Anita Brinker2Brian Buckley3Olivia Waysack4Amber Kautz5Ying Meng6Pamela Ohman Strickland7Robert Block8Susan W. Groth9Thomas G. O’Connor10Lauren M. Aleksunes11Emily S. Barrett12Environmental and Occupational Health Sciences Institute, Rutgers UniversityEnvironmental and Occupational Health Sciences Institute, Rutgers UniversityEnvironmental and Occupational Health Sciences Institute, Rutgers UniversityEnvironmental and Occupational Health Sciences Institute, Rutgers UniversityDepartment of Public Health Sciences, University of Rochester Medical CenterDepartment of Public Health Sciences, University of Rochester Medical CenterSchool of Nursing, University of RochesterDepartment of Biostatistics and Epidemiology, Rutgers University School of Public HealthDepartment of Public Health Sciences, University of Rochester Medical CenterSchool of Nursing, University of RochesterDepartment of Obstetrics and Gynecology, University of Rochester Medical CenterEnvironmental and Occupational Health Sciences Institute, Rutgers UniversityEnvironmental and Occupational Health Sciences Institute, Rutgers UniversityAbstract Background Zearalenone (ZEN), a secondary metabolite of Fusarium fungi, is one of the most common mycotoxins in global food supplies such as cereal grains and processed food. ZEN and its metabolites are commonly referred to as mycoestrogens, due to their ability to directly bind nuclear estrogen receptors α (ER-α) and β (ER-β). Zeranol, a synthetic mycoestrogen, is administered to U.S. cattle as a growth promoter. Despite widespread human exposure and ample evidence of adverse reproductive impacts in vitro and in vivo, there has been little epidemiological research on the health impacts of ZEN exposure during pregnancy. The objective of our study was to examine associations between ZEN and gestational weight gain (GWG). Methods Urine samples were collected in each trimester from pregnant participants in the UPSIDE cohort (n = 286, Rochester, NY, USA). High performance liquid chromatography and high-resolution tandem mass spectrometry were used to quantify concentrations of ZEN as well as ∑mycoestrogens (composite sum of ZEN metabolites; ng/ml). Maternal weights at clinical visits were abstracted from medical records. We fitted longitudinal models of specific-gravity adjusted, log-transformed ZEN and ∑mycoestrogens in relation to total GWG (kilograms) and GWG rate (kilograms/week). We additionally examined risk of excessive GWG (in relation to Institute of Medicine guidelines) and considered effect modification by fetal sex. Results ZEN and ∑mycoestrogens were detected in > 93% and > 95% of samples, respectively. Mycoestrogen concentrations were positively associated with total GWG (ZEN β:0.50 kg; 95%CI: 0.13, 0.87) and GWG rate (ZEN β:0.20 kg/week; 95%CI: 0.01, 0.03). Associations tended to be stronger among participants carrying male (versus female) fetuses and results were robust to adjustment for diet. Conclusions Mycoestrogen exposure during pregnancy may contribute to greater GWG. Future research is needed to understand potential influences on downstream maternal and offspring health.https://doi.org/10.1186/s12940-024-01141-8ZearalenonePregnancyGestational weight gainMycoestrogensEndocrine disrupting chemicals |
| spellingShingle | Carolyn W. Kinkade Zorimar Rivera-Núñez Anita Brinker Brian Buckley Olivia Waysack Amber Kautz Ying Meng Pamela Ohman Strickland Robert Block Susan W. Groth Thomas G. O’Connor Lauren M. Aleksunes Emily S. Barrett Urinary mycoestrogens and gestational weight gain in the UPSIDE pregnancy cohort Environmental Health Zearalenone Pregnancy Gestational weight gain Mycoestrogens Endocrine disrupting chemicals |
| title | Urinary mycoestrogens and gestational weight gain in the UPSIDE pregnancy cohort |
| title_full | Urinary mycoestrogens and gestational weight gain in the UPSIDE pregnancy cohort |
| title_fullStr | Urinary mycoestrogens and gestational weight gain in the UPSIDE pregnancy cohort |
| title_full_unstemmed | Urinary mycoestrogens and gestational weight gain in the UPSIDE pregnancy cohort |
| title_short | Urinary mycoestrogens and gestational weight gain in the UPSIDE pregnancy cohort |
| title_sort | urinary mycoestrogens and gestational weight gain in the upside pregnancy cohort |
| topic | Zearalenone Pregnancy Gestational weight gain Mycoestrogens Endocrine disrupting chemicals |
| url | https://doi.org/10.1186/s12940-024-01141-8 |
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