Health-related quality of life predicts prognosis in individuals with COPD hospitalized with community-acquired pneumonia – a prospective cohort study
Abstract Community-acquired pneumonia (CAP) in chronic obstructive pulmonary disease (COPD) often result in sudden and persistent reduction in health-related quality of life (HRQoL), which may be alleviated with palliative care. Among individuals with COPD, we aimed to investigate potential associat...
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Nature Portfolio
2024-11-01
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| Online Access: | https://doi.org/10.1038/s41598-024-74933-0 |
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| author | Maria Hein Hegelund Laura Jagerova Mette Frahm Olsen Camilla Koch Ryrsø Christian Ritz Arnold Matovu Dungu Lone Braagaard Andreas Vestergaard Jensen Rikke Krogh-Madsen Birgitte Lindegaard Daniel Faurholt-Jepsen |
| author_facet | Maria Hein Hegelund Laura Jagerova Mette Frahm Olsen Camilla Koch Ryrsø Christian Ritz Arnold Matovu Dungu Lone Braagaard Andreas Vestergaard Jensen Rikke Krogh-Madsen Birgitte Lindegaard Daniel Faurholt-Jepsen |
| author_sort | Maria Hein Hegelund |
| collection | DOAJ |
| description | Abstract Community-acquired pneumonia (CAP) in chronic obstructive pulmonary disease (COPD) often result in sudden and persistent reduction in health-related quality of life (HRQoL), which may be alleviated with palliative care. Among individuals with COPD, we aimed to investigate potential associations between HRQoL at admission with CAP and the risk of re-hospitalization and mortality and potential associations between specific HRQoL domains and CAP treatment outcomes. HRQoL was assessed at admission and the participants were grouped into tertiles based on the HRQoL utility index and specific domains. The results revealed that participants in the middle and highest tertiles of HRQoL had a lower 90-day re-hospitalization risk compared to those in the lowest tertile, whereas no differences in re-hospitalization risk were observed 30 and 180 days after discharge. Almost one in four had severe pain or discomfort at admission and the domain pain or discomfort emerged as a predictor of re-hospitalization. In addition, participants in the middle and highest tertiles had lower risk of 180-day mortality compared to those in the lowest, while no differences were observed in 30-day or 90-day mortality risk. An increased focus on in-hospital palliative care could alleviate the pain and discomfort reported by many participants with potential to reduce re-hospitalization rates. |
| format | Article |
| id | doaj-art-31387004048b4a7b8cfc84ae6c5d8fcb |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-31387004048b4a7b8cfc84ae6c5d8fcb2024-11-10T12:20:33ZengNature PortfolioScientific Reports2045-23222024-11-0114111310.1038/s41598-024-74933-0Health-related quality of life predicts prognosis in individuals with COPD hospitalized with community-acquired pneumonia – a prospective cohort studyMaria Hein Hegelund0Laura Jagerova1Mette Frahm Olsen2Camilla Koch Ryrsø3Christian Ritz4Arnold Matovu Dungu5Lone Braagaard6Andreas Vestergaard Jensen7Rikke Krogh-Madsen8Birgitte Lindegaard9Daniel Faurholt-Jepsen10Department of Pulmonary and Infectious Diseases, Copenhagen University Hospital, North ZealandDepartment of Nutrition, Exercise and Sports, University of CopenhagenDepartment of Nutrition, Exercise and Sports, University of CopenhagenDepartment of Pulmonary and Infectious Diseases, Copenhagen University Hospital, North ZealandNational Institute of Public Health, University of Southern DenmarkDepartment of Pulmonary and Infectious Diseases, Copenhagen University Hospital, North ZealandDepartment of Pulmonary and Infectious Diseases, Copenhagen University Hospital, North ZealandDepartment of Pulmonary and Infectious Diseases, Copenhagen University Hospital, North ZealandCentre for Physical Activity Research, Copenhagen University Hospital, RigshospitaletDepartment of Pulmonary and Infectious Diseases, Copenhagen University Hospital, North ZealandNational Institute of Public Health, University of Southern DenmarkAbstract Community-acquired pneumonia (CAP) in chronic obstructive pulmonary disease (COPD) often result in sudden and persistent reduction in health-related quality of life (HRQoL), which may be alleviated with palliative care. Among individuals with COPD, we aimed to investigate potential associations between HRQoL at admission with CAP and the risk of re-hospitalization and mortality and potential associations between specific HRQoL domains and CAP treatment outcomes. HRQoL was assessed at admission and the participants were grouped into tertiles based on the HRQoL utility index and specific domains. The results revealed that participants in the middle and highest tertiles of HRQoL had a lower 90-day re-hospitalization risk compared to those in the lowest tertile, whereas no differences in re-hospitalization risk were observed 30 and 180 days after discharge. Almost one in four had severe pain or discomfort at admission and the domain pain or discomfort emerged as a predictor of re-hospitalization. In addition, participants in the middle and highest tertiles had lower risk of 180-day mortality compared to those in the lowest, while no differences were observed in 30-day or 90-day mortality risk. An increased focus on in-hospital palliative care could alleviate the pain and discomfort reported by many participants with potential to reduce re-hospitalization rates.https://doi.org/10.1038/s41598-024-74933-0Chronic obstructive pulmonary diseaseCommunity-acquired pneumoniaHealth-related quality of lifePalliative careRe-hospitalizationMortality |
| spellingShingle | Maria Hein Hegelund Laura Jagerova Mette Frahm Olsen Camilla Koch Ryrsø Christian Ritz Arnold Matovu Dungu Lone Braagaard Andreas Vestergaard Jensen Rikke Krogh-Madsen Birgitte Lindegaard Daniel Faurholt-Jepsen Health-related quality of life predicts prognosis in individuals with COPD hospitalized with community-acquired pneumonia – a prospective cohort study Scientific Reports Chronic obstructive pulmonary disease Community-acquired pneumonia Health-related quality of life Palliative care Re-hospitalization Mortality |
| title | Health-related quality of life predicts prognosis in individuals with COPD hospitalized with community-acquired pneumonia – a prospective cohort study |
| title_full | Health-related quality of life predicts prognosis in individuals with COPD hospitalized with community-acquired pneumonia – a prospective cohort study |
| title_fullStr | Health-related quality of life predicts prognosis in individuals with COPD hospitalized with community-acquired pneumonia – a prospective cohort study |
| title_full_unstemmed | Health-related quality of life predicts prognosis in individuals with COPD hospitalized with community-acquired pneumonia – a prospective cohort study |
| title_short | Health-related quality of life predicts prognosis in individuals with COPD hospitalized with community-acquired pneumonia – a prospective cohort study |
| title_sort | health related quality of life predicts prognosis in individuals with copd hospitalized with community acquired pneumonia a prospective cohort study |
| topic | Chronic obstructive pulmonary disease Community-acquired pneumonia Health-related quality of life Palliative care Re-hospitalization Mortality |
| url | https://doi.org/10.1038/s41598-024-74933-0 |
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