Clinical and biological determinants of P-wave duration: cross-sectional data from the population-based CoLaus|PsyCoLaus study
Objectives P-wave duration (PWD) is associated with the development of atrial arrhythmias, cardiovascular and all-cause mortality. With this study, we aimed to assess the distribution and determinants of PWD in the general population.Design Cross-sectional study using data collected between 2014 and...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2020-11-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/10/11/e038828.full |
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| author | Pedro Marques-Vidal Peter Vollenweider Federica Bocchi Etienne Pruvot Gerard Waeber David Gachoud |
| author_facet | Pedro Marques-Vidal Peter Vollenweider Federica Bocchi Etienne Pruvot Gerard Waeber David Gachoud |
| author_sort | Pedro Marques-Vidal |
| collection | DOAJ |
| description | Objectives P-wave duration (PWD) is associated with the development of atrial arrhythmias, cardiovascular and all-cause mortality. With this study, we aimed to assess the distribution and determinants of PWD in the general population.Design Cross-sectional study using data collected between 2014 and 2016.Setting In the population-based cohort CoLaus|PsyCoLaus, Lausanne, Switzerland, we used 12-lead ECGs to measure PWD. Potential demographic, clinical and biological determinants of PWD were collected by questionnaire, anthropometry, blood pressure measurement and biological assays.Participants Data from 3459 participants (55% women, 62±10 years, 93% Caucasian) were included. Participants were excluded if they presented with (1) no sinus rhythm or paced rhythm on the study ECG or Wolff-Parkinson-White ECG pattern; (2) missing or non-interpretable ECG; and (3) missing phenotypic data.Primary outcome measure Determine (1) the PWD distribution and (2) the demographic, clinical and biological determinants of PWD in a large population-based cohort.Results Median and IQR of PWD was 112 (102–120) ms . In the multivariable analyses, PWD was significantly associated with age (p<0.001) and height (p<0.001), with an adjusted regression coefficient (95% CI) of 0.29 ms/years (0.23 to 0.36) and 0.32 ms/cm (0.28 to 0.37), respectively. PWD, given thereafter in ms with adjusted mean±SE, was significantly (p<0.05) associated with (a) gender (woman 110.0±0.4; man 112.1±0.4), (b) body mass index (normal 110.1±0.4; overweight 110.9±0.4; obese 113.0±0.5), (c) abdominal obesity (no 110.5±0.3; yes 111.7±0.4) and (d) hypertension (no 110.4±0.3; yes 111.7±0.4).Conclusion PWD is positively associated with age, height, male gender, obesity markers and hypertension. Clinical interpretation of PWD should take these factors into consideration. |
| format | Article |
| id | doaj-art-31303faa6ae04e738f41b3f5252e79f4 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2020-11-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-31303faa6ae04e738f41b3f5252e79f42024-11-27T21:30:11ZengBMJ Publishing GroupBMJ Open2044-60552020-11-01101110.1136/bmjopen-2020-038828Clinical and biological determinants of P-wave duration: cross-sectional data from the population-based CoLaus|PsyCoLaus studyPedro Marques-Vidal0Peter Vollenweider1Federica Bocchi2Etienne Pruvot3Gerard Waeber4David Gachoud5Medicine, Internal Medicine, Lausanne University Hospital (CHUV), Lausanne, SwitzerlandInternal Medicine, CHUV, Lausanne, SwitzerlandInternal Medicine, CHUV, Lausanne, SwitzerlandCardiology, CHUV, Lausanne, SwitzerlandInternal Medicine, CHUV, Lausanne, SwitzerlandInternal Medicine, CHUV, Lausanne, SwitzerlandObjectives P-wave duration (PWD) is associated with the development of atrial arrhythmias, cardiovascular and all-cause mortality. With this study, we aimed to assess the distribution and determinants of PWD in the general population.Design Cross-sectional study using data collected between 2014 and 2016.Setting In the population-based cohort CoLaus|PsyCoLaus, Lausanne, Switzerland, we used 12-lead ECGs to measure PWD. Potential demographic, clinical and biological determinants of PWD were collected by questionnaire, anthropometry, blood pressure measurement and biological assays.Participants Data from 3459 participants (55% women, 62±10 years, 93% Caucasian) were included. Participants were excluded if they presented with (1) no sinus rhythm or paced rhythm on the study ECG or Wolff-Parkinson-White ECG pattern; (2) missing or non-interpretable ECG; and (3) missing phenotypic data.Primary outcome measure Determine (1) the PWD distribution and (2) the demographic, clinical and biological determinants of PWD in a large population-based cohort.Results Median and IQR of PWD was 112 (102–120) ms . In the multivariable analyses, PWD was significantly associated with age (p<0.001) and height (p<0.001), with an adjusted regression coefficient (95% CI) of 0.29 ms/years (0.23 to 0.36) and 0.32 ms/cm (0.28 to 0.37), respectively. PWD, given thereafter in ms with adjusted mean±SE, was significantly (p<0.05) associated with (a) gender (woman 110.0±0.4; man 112.1±0.4), (b) body mass index (normal 110.1±0.4; overweight 110.9±0.4; obese 113.0±0.5), (c) abdominal obesity (no 110.5±0.3; yes 111.7±0.4) and (d) hypertension (no 110.4±0.3; yes 111.7±0.4).Conclusion PWD is positively associated with age, height, male gender, obesity markers and hypertension. Clinical interpretation of PWD should take these factors into consideration.https://bmjopen.bmj.com/content/10/11/e038828.full |
| spellingShingle | Pedro Marques-Vidal Peter Vollenweider Federica Bocchi Etienne Pruvot Gerard Waeber David Gachoud Clinical and biological determinants of P-wave duration: cross-sectional data from the population-based CoLaus|PsyCoLaus study BMJ Open |
| title | Clinical and biological determinants of P-wave duration: cross-sectional data from the population-based CoLaus|PsyCoLaus study |
| title_full | Clinical and biological determinants of P-wave duration: cross-sectional data from the population-based CoLaus|PsyCoLaus study |
| title_fullStr | Clinical and biological determinants of P-wave duration: cross-sectional data from the population-based CoLaus|PsyCoLaus study |
| title_full_unstemmed | Clinical and biological determinants of P-wave duration: cross-sectional data from the population-based CoLaus|PsyCoLaus study |
| title_short | Clinical and biological determinants of P-wave duration: cross-sectional data from the population-based CoLaus|PsyCoLaus study |
| title_sort | clinical and biological determinants of p wave duration cross sectional data from the population based colaus psycolaus study |
| url | https://bmjopen.bmj.com/content/10/11/e038828.full |
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