Evaluation of the cytotoxic activity and toxicity of a tropolone derivative with a potential antitumor effect

Evaluation of the cytotoxic activity and toxicity of a tropolone derivative with a potential antitumor effect

The aim. To study the toxicity of 2-(6,8-dimethyl-5-nitro-4-chloroquinoline-2-yl)-5,6,7-trichloro-1,3-tropolone in vitro and in vivo.Materials and methods. 2-(6,8-dimethyl-5-nitro-4-chloroquinoline-2-yl)-5,6,7-trichloro-1,3-tropolone was synthesized using a method for expanding the o-quinone cycle d...

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Main Authors: O. I. Kit, V. I. Minkin, E. A. Lukbanova, Yu. A. Sayapin, E. A. Gusakov, A. O. Sitkovskaya, S. Yu. Filippova, E. F. Komarova, A. V. Volkova, D. V. Khodakova, M. V. Mindar, Yu. N. Lazutin, M. A. Engibaryan, V. E. Kolesnikov
Format: Article
Language:English
Published: Siberian State Medical University (Tomsk) 2022-07-01
Series:Бюллетень сибирской медицины
Subjects:
tropolones
antitumor effect4 human non-small-cell lung cancer а549 cell line
mtt assay
Online Access:https://bulletin.ssmu.ru/jour/article/view/4814
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