Oropharyngeal colostrum immunotherapy and late-onset neonatal sepsis: an intervention study
Abstract Objectives: to evaluate the effect of oropharyngeal colostrum immunotherapy in reducing cases of late-onset neonatal sepsis in preterm infants with very low birth weight. Methods: this is an intervention study, with a comparative analysis between the incidence of late-onset neonatal sepsi...
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Instituto Materno Infantil de Pernambuco
2024-12-01
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| Series: | Revista Brasileira de Saúde Materno Infantil |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1519-38292024000100450&lng=en&tlng=en |
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| author | Gabriela Cintra dos Santos Tatiana de Oliveira Vieira Camilla da Cruz Martins Matheus Gomes Reis Costa Graciete Oliveira Vieira |
| author_facet | Gabriela Cintra dos Santos Tatiana de Oliveira Vieira Camilla da Cruz Martins Matheus Gomes Reis Costa Graciete Oliveira Vieira |
| author_sort | Gabriela Cintra dos Santos |
| collection | DOAJ |
| description | Abstract Objectives: to evaluate the effect of oropharyngeal colostrum immunotherapy in reducing cases of late-onset neonatal sepsis in preterm infants with very low birth weight. Methods: this is an intervention study, with a comparative analysis between the incidence of late-onset neonatal sepsis in the treatment group (in use of oropharyngeal colostrum immunotherapy) and the historical control group (newborns monitored in the same intensive care unit prior to the implementation of the oropharyngeal colostrum immunotherapy protocol). 81 premature babies born between 2016 and 2022 participated in the study separated according to whether or not they received oropharyngeal colostrum immunotherapy. The intervention consisted of eight daily applications of 0.2 mL of the mother's own raw colostrum to the newborns oral mucosa during the first seven days of life. Relative Risk and Absolute Risk Reduction and Number needed to Treat were calculated. Results: a protective effect of oropharyngeal colostrum immunotherapy against late neonatal sepsis was noted. Relative Risk: 0.43; CI95% = 0.21-0.91; Absolute Risk Reduction: 0.26; CI95%= 6.51 - 45.92 and Number Needed to Treat: 4 (2.17-15.34). Conclusion: administration of oropharyngeal colostrum proved to be a promising measure in protecting preterm newborns with VLBW against late-onset sepsis. |
| format | Article |
| id | doaj-art-30c443cb7f2d4bad8e6e12841ac9968a |
| institution | Kabale University |
| issn | 1806-9304 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Instituto Materno Infantil de Pernambuco |
| record_format | Article |
| series | Revista Brasileira de Saúde Materno Infantil |
| spelling | doaj-art-30c443cb7f2d4bad8e6e12841ac9968a2024-12-17T07:52:20ZengInstituto Materno Infantil de PernambucoRevista Brasileira de Saúde Materno Infantil1806-93042024-12-012410.1590/1806-9304202400000104-enOropharyngeal colostrum immunotherapy and late-onset neonatal sepsis: an intervention studyGabriela Cintra dos Santoshttps://orcid.org/0000-0002-8681-5635Tatiana de Oliveira Vieirahttps://orcid.org/0000-0002-5039-5077Camilla da Cruz Martinshttps://orcid.org/0000-0002-6946-4618Matheus Gomes Reis Costahttps://orcid.org/0000-0003-1288-5646Graciete Oliveira Vieirahttps://orcid.org/0000-0001-5354-718XAbstract Objectives: to evaluate the effect of oropharyngeal colostrum immunotherapy in reducing cases of late-onset neonatal sepsis in preterm infants with very low birth weight. Methods: this is an intervention study, with a comparative analysis between the incidence of late-onset neonatal sepsis in the treatment group (in use of oropharyngeal colostrum immunotherapy) and the historical control group (newborns monitored in the same intensive care unit prior to the implementation of the oropharyngeal colostrum immunotherapy protocol). 81 premature babies born between 2016 and 2022 participated in the study separated according to whether or not they received oropharyngeal colostrum immunotherapy. The intervention consisted of eight daily applications of 0.2 mL of the mother's own raw colostrum to the newborns oral mucosa during the first seven days of life. Relative Risk and Absolute Risk Reduction and Number needed to Treat were calculated. Results: a protective effect of oropharyngeal colostrum immunotherapy against late neonatal sepsis was noted. Relative Risk: 0.43; CI95% = 0.21-0.91; Absolute Risk Reduction: 0.26; CI95%= 6.51 - 45.92 and Number Needed to Treat: 4 (2.17-15.34). Conclusion: administration of oropharyngeal colostrum proved to be a promising measure in protecting preterm newborns with VLBW against late-onset sepsis.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1519-38292024000100450&lng=en&tlng=enPremature newbornColostrumNeonatal sepsisImmunotherapyIntervention studies |
| spellingShingle | Gabriela Cintra dos Santos Tatiana de Oliveira Vieira Camilla da Cruz Martins Matheus Gomes Reis Costa Graciete Oliveira Vieira Oropharyngeal colostrum immunotherapy and late-onset neonatal sepsis: an intervention study Revista Brasileira de Saúde Materno Infantil Premature newborn Colostrum Neonatal sepsis Immunotherapy Intervention studies |
| title | Oropharyngeal colostrum immunotherapy and late-onset neonatal sepsis: an intervention study |
| title_full | Oropharyngeal colostrum immunotherapy and late-onset neonatal sepsis: an intervention study |
| title_fullStr | Oropharyngeal colostrum immunotherapy and late-onset neonatal sepsis: an intervention study |
| title_full_unstemmed | Oropharyngeal colostrum immunotherapy and late-onset neonatal sepsis: an intervention study |
| title_short | Oropharyngeal colostrum immunotherapy and late-onset neonatal sepsis: an intervention study |
| title_sort | oropharyngeal colostrum immunotherapy and late onset neonatal sepsis an intervention study |
| topic | Premature newborn Colostrum Neonatal sepsis Immunotherapy Intervention studies |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1519-38292024000100450&lng=en&tlng=en |
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