Inhibition of the E3 ligase UBR5 stabilizes TERT and protects vascular organoids from oxidative stress

Inhibition of the E3 ligase UBR5 stabilizes TERT and protects vascular organoids from oxidative stress

Abstract Background Excessive oxidative stress is known to cause endothelial dysfunction and drive cardiovascular diseases (CVD). While telomerase reverse transcriptase (TERT) shows protective effects against oxidative stress in rodents and is associated to human flow-mediated dilation in CVD, its r...

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Main Authors: Haijing Zhao, Nian Cao, Qi Liu, Yingyue Zhang, Rui Jin, Huiying Lai, Li Zheng, Honghong Zhang, Yue Zhu, Yuhan Ma, Zengao Yang, Zhengfeng Wu, Weini Li, Yuqi Liu, Long Cheng, Yundai Chen
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Journal of Translational Medicine
Subjects:
Vascular organoids
UBR5
TERT
Senescence
Oxidative stress
Online Access:https://doi.org/10.1186/s12967-024-05887-0
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