Effect and safety of sivelestat on acute severe pancreatitis with systemic inflammatory response syndrome: a retrospective study
Abstract The study was to explore the efficacy and safety of sivelestat (SV) in the treatment of severe acute pancreatitis (SAP) with systemic inflammatory response syndrome (SIRS). A total of 102 SAP patients diagnosed and treated in the Emergency Intensive Care Unit of the First Affiliated Hospita...
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Nature Portfolio
2025-01-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-84600-z |
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| author | Jiafeng Xie Ruyi Lei Hui Pei Yulei Gu Luanluan Zhang Jingrong Liu Yahui Huang Yepeng Zhang Yanan Zi Changju Zhu Zhiqiang Zhu |
| author_facet | Jiafeng Xie Ruyi Lei Hui Pei Yulei Gu Luanluan Zhang Jingrong Liu Yahui Huang Yepeng Zhang Yanan Zi Changju Zhu Zhiqiang Zhu |
| author_sort | Jiafeng Xie |
| collection | DOAJ |
| description | Abstract The study was to explore the efficacy and safety of sivelestat (SV) in the treatment of severe acute pancreatitis (SAP) with systemic inflammatory response syndrome (SIRS). A total of 102 SAP patients diagnosed and treated in the Emergency Intensive Care Unit of the First Affiliated Hospital of Zhengzhou University from January 2021 to August 2024 were selected. The changes of disease outcome, hospital stays and mortality were compared between the two groups. A total of 102 patients were recruited to control group (n = 56) or SV group (n = 46) according to whether SV was applied or not. There was no significant difference in baseline data at admission between the two groups. After 1 week of treatment, all the indexes in both groups improved. The duration of ventilator use (p = 0.0400) and ICU stays (p = 0.0495) in SV group was shorter than that in control group, but there was no significant difference in mortality between the two groups. Although SV did not reduce the mortality of patients with SAP, it reduced the length of ventilator use and ICU stay. |
| format | Article |
| id | doaj-art-307c9f8032ec4389ae02b6e12baf1a2b |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-307c9f8032ec4389ae02b6e12baf1a2b2025-01-05T12:22:48ZengNature PortfolioScientific Reports2045-23222025-01-011511710.1038/s41598-024-84600-zEffect and safety of sivelestat on acute severe pancreatitis with systemic inflammatory response syndrome: a retrospective studyJiafeng Xie0Ruyi Lei1Hui Pei2Yulei Gu3Luanluan Zhang4Jingrong Liu5Yahui Huang6Yepeng Zhang7Yanan Zi8Changju Zhu9Zhiqiang Zhu10Department of emergency ICU, the first affiliated hospital of Zhengzhou UniversityDepartment of emergency ICU, the first affiliated hospital of Zhengzhou UniversityDepartment of emergency ICU, the first affiliated hospital of Zhengzhou UniversityDepartment of emergency ICU, the first affiliated hospital of Zhengzhou UniversityDepartment of emergency ICU, the first affiliated hospital of Zhengzhou UniversityDepartment of emergency ICU, the first affiliated hospital of Zhengzhou UniversityDepartment of emergency ICU, the first affiliated hospital of Zhengzhou UniversityDepartment of emergency ICU, the first affiliated hospital of Zhengzhou UniversityDepartment of emergency ICU, the first affiliated hospital of Zhengzhou UniversityDepartment of emergency ICU, the first affiliated hospital of Zhengzhou UniversityDepartment of emergency ICU, the first affiliated hospital of Zhengzhou UniversityAbstract The study was to explore the efficacy and safety of sivelestat (SV) in the treatment of severe acute pancreatitis (SAP) with systemic inflammatory response syndrome (SIRS). A total of 102 SAP patients diagnosed and treated in the Emergency Intensive Care Unit of the First Affiliated Hospital of Zhengzhou University from January 2021 to August 2024 were selected. The changes of disease outcome, hospital stays and mortality were compared between the two groups. A total of 102 patients were recruited to control group (n = 56) or SV group (n = 46) according to whether SV was applied or not. There was no significant difference in baseline data at admission between the two groups. After 1 week of treatment, all the indexes in both groups improved. The duration of ventilator use (p = 0.0400) and ICU stays (p = 0.0495) in SV group was shorter than that in control group, but there was no significant difference in mortality between the two groups. Although SV did not reduce the mortality of patients with SAP, it reduced the length of ventilator use and ICU stay.https://doi.org/10.1038/s41598-024-84600-zSivelestatSevere acute pancreatitisSystemic inflammatory response syndrome |
| spellingShingle | Jiafeng Xie Ruyi Lei Hui Pei Yulei Gu Luanluan Zhang Jingrong Liu Yahui Huang Yepeng Zhang Yanan Zi Changju Zhu Zhiqiang Zhu Effect and safety of sivelestat on acute severe pancreatitis with systemic inflammatory response syndrome: a retrospective study Scientific Reports Sivelestat Severe acute pancreatitis Systemic inflammatory response syndrome |
| title | Effect and safety of sivelestat on acute severe pancreatitis with systemic inflammatory response syndrome: a retrospective study |
| title_full | Effect and safety of sivelestat on acute severe pancreatitis with systemic inflammatory response syndrome: a retrospective study |
| title_fullStr | Effect and safety of sivelestat on acute severe pancreatitis with systemic inflammatory response syndrome: a retrospective study |
| title_full_unstemmed | Effect and safety of sivelestat on acute severe pancreatitis with systemic inflammatory response syndrome: a retrospective study |
| title_short | Effect and safety of sivelestat on acute severe pancreatitis with systemic inflammatory response syndrome: a retrospective study |
| title_sort | effect and safety of sivelestat on acute severe pancreatitis with systemic inflammatory response syndrome a retrospective study |
| topic | Sivelestat Severe acute pancreatitis Systemic inflammatory response syndrome |
| url | https://doi.org/10.1038/s41598-024-84600-z |
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