Harnessing Bacillus Species for Antibiotic Discovery: A Review
The genus Bacillus is a group of rod-shaped, gram-positive bacteria known for their vast potential of the production of antibiotics. This review examines the potentials of various Bacillus species in the production of antibiotics. There is a global threat of antimicrobial resistance and have spurre...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Biotechnology Society of Nepal
2024-12-01
|
| Series: | Nepal Journal of Biotechnology |
| Subjects: | |
| Online Access: | https://www.nepjb.com/index.php/NJB/article/view/338 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841556027901739008 |
|---|---|
| author | Daniel Tunde Abbey Aisha Tajudeen Oganija Onyibo Leonard Ebube Dim Emmanuel Ifeanyi |
| author_facet | Daniel Tunde Abbey Aisha Tajudeen Oganija Onyibo Leonard Ebube Dim Emmanuel Ifeanyi |
| author_sort | Daniel Tunde Abbey |
| collection | DOAJ |
| description |
The genus Bacillus is a group of rod-shaped, gram-positive bacteria known for their vast potential of the production of antibiotics. This review examines the potentials of various Bacillus species in the production of antibiotics. There is a global threat of antimicrobial resistance and have spurred the need in scientific research for novel antibiotics and Bacillus species offers a ray of hope in the discovery of novel antibiotics. Notable among the antibiotics produced by Bacillus species include fengycin, gramicidin, iturin, polymyxin, subtilin, difficidin, surfactin, megacin, lichenysin, bacitracin, cerein, pumilicin, circulin, each with greater stability and wide spectrum of activity against gram-positive as well as gram-negative bacteria, fungi. This review highlights the various Bacillus species with antibiotics producing abilities such as B. subtilis, B. polymyxa, B. cereus, B. pumilus, B. megaterium, B. circulans, the antibiotics produced by these Bacillus species, mechanisms of actions of these antibiotics, potential application in medicine, agriculture, biotechnology and industry. Bacillus species with antibiotics producing potentials can be applied in combatting the threat posed by antibiotic-resistant pathogens as well as multi-drug-resistant pathogens.
|
| format | Article |
| id | doaj-art-30496ba70fbf4e9bbca91b0fd74b64f2 |
| institution | Kabale University |
| issn | 2091-1130 2467-9313 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Biotechnology Society of Nepal |
| record_format | Article |
| series | Nepal Journal of Biotechnology |
| spelling | doaj-art-30496ba70fbf4e9bbca91b0fd74b64f22025-01-07T14:47:04ZengBiotechnology Society of NepalNepal Journal of Biotechnology2091-11302467-93132024-12-0112210.54796/njb.v12i2.338Harnessing Bacillus Species for Antibiotic Discovery: A ReviewDaniel Tunde Abbey0Aisha Tajudeen Oganija1Onyibo Leonard Ebube2Dim Emmanuel Ifeanyi3Department of Microbiology and Biotechnology, Federal University Dutse, PMB 7156 Dutse, NigeriaDepartment of Microbiology and Biotechnology, Federal University Dutse, PMB 7156 Dutse, NigeriaDepartment of Microbiology and Biotechnology, Federal University Dutse, PMB 7156 Dutse, NigeriaDepartment of Microbiology and Biotechnology, Federal University Dutse, PMB 7156 Dutse, Nigeria The genus Bacillus is a group of rod-shaped, gram-positive bacteria known for their vast potential of the production of antibiotics. This review examines the potentials of various Bacillus species in the production of antibiotics. There is a global threat of antimicrobial resistance and have spurred the need in scientific research for novel antibiotics and Bacillus species offers a ray of hope in the discovery of novel antibiotics. Notable among the antibiotics produced by Bacillus species include fengycin, gramicidin, iturin, polymyxin, subtilin, difficidin, surfactin, megacin, lichenysin, bacitracin, cerein, pumilicin, circulin, each with greater stability and wide spectrum of activity against gram-positive as well as gram-negative bacteria, fungi. This review highlights the various Bacillus species with antibiotics producing abilities such as B. subtilis, B. polymyxa, B. cereus, B. pumilus, B. megaterium, B. circulans, the antibiotics produced by these Bacillus species, mechanisms of actions of these antibiotics, potential application in medicine, agriculture, biotechnology and industry. Bacillus species with antibiotics producing potentials can be applied in combatting the threat posed by antibiotic-resistant pathogens as well as multi-drug-resistant pathogens. https://www.nepjb.com/index.php/NJB/article/view/338Bacillus speciesantibiotics discoverysecondary metabolitesantimicrobial resistanceAntibiotics |
| spellingShingle | Daniel Tunde Abbey Aisha Tajudeen Oganija Onyibo Leonard Ebube Dim Emmanuel Ifeanyi Harnessing Bacillus Species for Antibiotic Discovery: A Review Nepal Journal of Biotechnology Bacillus species antibiotics discovery secondary metabolites antimicrobial resistance Antibiotics |
| title | Harnessing Bacillus Species for Antibiotic Discovery: A Review |
| title_full | Harnessing Bacillus Species for Antibiotic Discovery: A Review |
| title_fullStr | Harnessing Bacillus Species for Antibiotic Discovery: A Review |
| title_full_unstemmed | Harnessing Bacillus Species for Antibiotic Discovery: A Review |
| title_short | Harnessing Bacillus Species for Antibiotic Discovery: A Review |
| title_sort | harnessing bacillus species for antibiotic discovery a review |
| topic | Bacillus species antibiotics discovery secondary metabolites antimicrobial resistance Antibiotics |
| url | https://www.nepjb.com/index.php/NJB/article/view/338 |
| work_keys_str_mv | AT danieltundeabbey harnessingbacillusspeciesforantibioticdiscoveryareview AT aishatajudeenoganija harnessingbacillusspeciesforantibioticdiscoveryareview AT onyiboleonardebube harnessingbacillusspeciesforantibioticdiscoveryareview AT dimemmanuelifeanyi harnessingbacillusspeciesforantibioticdiscoveryareview |