Indirect effects of serum metabolites in the influence of the DASH diet on systolic blood pressure: The Taizhou imaging study
The DASH dietary pattern has been shown to decrease systolic blood pressure (SBP), whereas the mechanisms remain incompletely understood. The objective of this cross-sectional study was to ascertain whether serum metabolites mediated the association between the DASH diet and SBP utilizing non-target...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-01-01
|
| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464624006352 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841545492679360512 |
|---|---|
| author | Yawen Wang Yi Zheng Xin Zhang Jincheng Li Yucan Li Chengjun Zhang Ningxin Gao Jiacheng Wang Min Fan Weizhong Tian Yanfeng Jiang Yingzhe Wang Mei Cui Chen Suo Tiejun Zhang Li Jin Xingdong Chen Kelin Xu |
| author_facet | Yawen Wang Yi Zheng Xin Zhang Jincheng Li Yucan Li Chengjun Zhang Ningxin Gao Jiacheng Wang Min Fan Weizhong Tian Yanfeng Jiang Yingzhe Wang Mei Cui Chen Suo Tiejun Zhang Li Jin Xingdong Chen Kelin Xu |
| author_sort | Yawen Wang |
| collection | DOAJ |
| description | The DASH dietary pattern has been shown to decrease systolic blood pressure (SBP), whereas the mechanisms remain incompletely understood. The objective of this cross-sectional study was to ascertain whether serum metabolites mediated the association between the DASH diet and SBP utilizing non-targeted metabolomic techniques in the Taizhou Imaging Study. The DASH score was calculated using data collected by food frequency questionnaires. Adherence to the DASH diet was linked to lower SBP (β = −2.61; 95 % CI: −4.12, −1.20). It was observed that lipid and lipoprotein metabolites suppressed the relationship between the DASH score and SBP (The ratio of suppressing effect was 0.059). Moreover, acetic acid and glucose demonstrated significant mediation effects in the parallel mediation model (The proportion of mediation effect was 22.87 %). Among the components of the DASH diet, we revealed that 2 subfractions of very low-density lipoprotein had suppression effects, while acetic acid mediated the association between vegetable intake and SBP. These findings provide evidence for indirect effects of serum metabolites in the influence of DASH diet on SBP. |
| format | Article |
| id | doaj-art-300f216ccdf24bfb975fe58113bef85e |
| institution | Kabale University |
| issn | 1756-4646 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj-art-300f216ccdf24bfb975fe58113bef85e2025-01-12T05:24:44ZengElsevierJournal of Functional Foods1756-46462025-01-01124106632Indirect effects of serum metabolites in the influence of the DASH diet on systolic blood pressure: The Taizhou imaging studyYawen Wang0Yi Zheng1Xin Zhang2Jincheng Li3Yucan Li4Chengjun Zhang5Ningxin Gao6Jiacheng Wang7Min Fan8Weizhong Tian9Yanfeng Jiang10Yingzhe Wang11Mei Cui12Chen Suo13Tiejun Zhang14Li Jin15Xingdong Chen16Kelin Xu17Department of Biostatistics, School of Public Health, and the Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, ChinaState Key Laboratory of Genetic Engineering, Zhangjiang Fudan International Innovation Center, Human Phenome Institute, Fudan University, Shanghai, ChinaDepartment of Epidemiology, School of Public Health, and the Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, ChinaState Key Laboratory of Genetic Engineering, Zhangjiang Fudan International Innovation Center, Human Phenome Institute, Fudan University, Shanghai, ChinaState Key Laboratory of Genetic Engineering, Zhangjiang Fudan International Innovation Center, Human Phenome Institute, Fudan University, Shanghai, ChinaDepartment of Epidemiology, School of Public Health, and the Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, ChinaDepartment of Biostatistics, School of Public Health, and the Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, ChinaDepartment of Epidemiology, School of Public Health, and the Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, ChinaTaixing Disease Control and Prevention Center, Taizhou, Jiangsu, ChinaTaizhou People's Hospital Affiliated to Nantong University, Taizhou, Jiangsu, ChinaState Key Laboratory of Genetic Engineering, Zhangjiang Fudan International Innovation Center, Human Phenome Institute, Fudan University, Shanghai, China; Fudan University Taizhou Institute of Health Sciences, Taizhou, Jiangsu, ChinaState Key Laboratory of Genetic Engineering, Zhangjiang Fudan International Innovation Center, Human Phenome Institute, Fudan University, Shanghai, China; Fudan University Taizhou Institute of Health Sciences, Taizhou, Jiangsu, ChinaFudan University Taizhou Institute of Health Sciences, Taizhou, Jiangsu, China; Department of Neurology, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Epidemiology, School of Public Health, and the Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, China; Fudan University Taizhou Institute of Health Sciences, Taizhou, Jiangsu, ChinaDepartment of Epidemiology, School of Public Health, and the Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, China; Fudan University Taizhou Institute of Health Sciences, Taizhou, Jiangsu, ChinaState Key Laboratory of Genetic Engineering, Zhangjiang Fudan International Innovation Center, Human Phenome Institute, Fudan University, Shanghai, China; Fudan University Taizhou Institute of Health Sciences, Taizhou, Jiangsu, ChinaState Key Laboratory of Genetic Engineering, Zhangjiang Fudan International Innovation Center, Human Phenome Institute, Fudan University, Shanghai, China; Fudan University Taizhou Institute of Health Sciences, Taizhou, Jiangsu, China; National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China; Yiwu Research Institute of Fudan University, Yiwu, Zhejiang, China; Corresponding author at: State Key Laboratory of Genetic Engineering, Zhangjiang Fudan International Innovation Center, Human Phenome Institute, Fudan University, Shanghai, China.Department of Biostatistics, School of Public Health, and the Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, China; Fudan University Taizhou Institute of Health Sciences, Taizhou, Jiangsu, China; Corresponding author at: Department of Biostatistics, School of Public Health, and the Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, China.The DASH dietary pattern has been shown to decrease systolic blood pressure (SBP), whereas the mechanisms remain incompletely understood. The objective of this cross-sectional study was to ascertain whether serum metabolites mediated the association between the DASH diet and SBP utilizing non-targeted metabolomic techniques in the Taizhou Imaging Study. The DASH score was calculated using data collected by food frequency questionnaires. Adherence to the DASH diet was linked to lower SBP (β = −2.61; 95 % CI: −4.12, −1.20). It was observed that lipid and lipoprotein metabolites suppressed the relationship between the DASH score and SBP (The ratio of suppressing effect was 0.059). Moreover, acetic acid and glucose demonstrated significant mediation effects in the parallel mediation model (The proportion of mediation effect was 22.87 %). Among the components of the DASH diet, we revealed that 2 subfractions of very low-density lipoprotein had suppression effects, while acetic acid mediated the association between vegetable intake and SBP. These findings provide evidence for indirect effects of serum metabolites in the influence of DASH diet on SBP.http://www.sciencedirect.com/science/article/pii/S1756464624006352Blood pressureDASH dietary patternMediation analysisSerum metabolites |
| spellingShingle | Yawen Wang Yi Zheng Xin Zhang Jincheng Li Yucan Li Chengjun Zhang Ningxin Gao Jiacheng Wang Min Fan Weizhong Tian Yanfeng Jiang Yingzhe Wang Mei Cui Chen Suo Tiejun Zhang Li Jin Xingdong Chen Kelin Xu Indirect effects of serum metabolites in the influence of the DASH diet on systolic blood pressure: The Taizhou imaging study Journal of Functional Foods Blood pressure DASH dietary pattern Mediation analysis Serum metabolites |
| title | Indirect effects of serum metabolites in the influence of the DASH diet on systolic blood pressure: The Taizhou imaging study |
| title_full | Indirect effects of serum metabolites in the influence of the DASH diet on systolic blood pressure: The Taizhou imaging study |
| title_fullStr | Indirect effects of serum metabolites in the influence of the DASH diet on systolic blood pressure: The Taizhou imaging study |
| title_full_unstemmed | Indirect effects of serum metabolites in the influence of the DASH diet on systolic blood pressure: The Taizhou imaging study |
| title_short | Indirect effects of serum metabolites in the influence of the DASH diet on systolic blood pressure: The Taizhou imaging study |
| title_sort | indirect effects of serum metabolites in the influence of the dash diet on systolic blood pressure the taizhou imaging study |
| topic | Blood pressure DASH dietary pattern Mediation analysis Serum metabolites |
| url | http://www.sciencedirect.com/science/article/pii/S1756464624006352 |
| work_keys_str_mv | AT yawenwang indirecteffectsofserummetabolitesintheinfluenceofthedashdietonsystolicbloodpressurethetaizhouimagingstudy AT yizheng indirecteffectsofserummetabolitesintheinfluenceofthedashdietonsystolicbloodpressurethetaizhouimagingstudy AT xinzhang indirecteffectsofserummetabolitesintheinfluenceofthedashdietonsystolicbloodpressurethetaizhouimagingstudy AT jinchengli indirecteffectsofserummetabolitesintheinfluenceofthedashdietonsystolicbloodpressurethetaizhouimagingstudy AT yucanli indirecteffectsofserummetabolitesintheinfluenceofthedashdietonsystolicbloodpressurethetaizhouimagingstudy AT chengjunzhang indirecteffectsofserummetabolitesintheinfluenceofthedashdietonsystolicbloodpressurethetaizhouimagingstudy AT ningxingao indirecteffectsofserummetabolitesintheinfluenceofthedashdietonsystolicbloodpressurethetaizhouimagingstudy AT jiachengwang indirecteffectsofserummetabolitesintheinfluenceofthedashdietonsystolicbloodpressurethetaizhouimagingstudy AT minfan indirecteffectsofserummetabolitesintheinfluenceofthedashdietonsystolicbloodpressurethetaizhouimagingstudy AT weizhongtian indirecteffectsofserummetabolitesintheinfluenceofthedashdietonsystolicbloodpressurethetaizhouimagingstudy AT yanfengjiang indirecteffectsofserummetabolitesintheinfluenceofthedashdietonsystolicbloodpressurethetaizhouimagingstudy AT yingzhewang indirecteffectsofserummetabolitesintheinfluenceofthedashdietonsystolicbloodpressurethetaizhouimagingstudy AT meicui indirecteffectsofserummetabolitesintheinfluenceofthedashdietonsystolicbloodpressurethetaizhouimagingstudy AT chensuo indirecteffectsofserummetabolitesintheinfluenceofthedashdietonsystolicbloodpressurethetaizhouimagingstudy AT tiejunzhang indirecteffectsofserummetabolitesintheinfluenceofthedashdietonsystolicbloodpressurethetaizhouimagingstudy AT lijin indirecteffectsofserummetabolitesintheinfluenceofthedashdietonsystolicbloodpressurethetaizhouimagingstudy AT xingdongchen indirecteffectsofserummetabolitesintheinfluenceofthedashdietonsystolicbloodpressurethetaizhouimagingstudy AT kelinxu indirecteffectsofserummetabolitesintheinfluenceofthedashdietonsystolicbloodpressurethetaizhouimagingstudy |