Evaluation of clinical efficacy of gamithromycin in the treatment of naturally infected neonatal calves with cryptosporidiosis
<b>Aim: </b>The purpose of this study was to investigate the clinical efficacy of gamithromycin in the treatment of naturally infected neonatal calves with cryptosporidiosis.<p> <b>Materials and Methods: </b>5-20 days old 20 diarrheic neonatal calves were used as materi...
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| Format: | Article |
| Language: | English |
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Selcuk University Press
2021-03-01
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| Series: | Eurasian Journal of Veterinary Sciences |
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| Online Access: | http://eurasianjvetsci.org/pdf.php3?id=1346 |
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| author | Mahmut Ok Ferda Sevinç Merve İder Onur Ceylan Alper Ertürk Ceylan Ceylan Murat Kaan Durgut |
| author_facet | Mahmut Ok Ferda Sevinç Merve İder Onur Ceylan Alper Ertürk Ceylan Ceylan Murat Kaan Durgut |
| author_sort | Mahmut Ok |
| collection | DOAJ |
| description | <b>Aim: </b>The purpose of this study was to investigate the clinical efficacy of gamithromycin
in the treatment of naturally infected neonatal calves with
cryptosporidiosis.<p>
<b>Materials and Methods: </b>5-20 days old 20 diarrheic neonatal calves were used
as material in this study. Diagnosis of cryptosporidiosis was made by microscopic
examination and ELISA test. Calves shedding Cryptosporidium oocysts
between 4 x 10<sup>4</sup> and 15 x 10<sup>6</sup> per gram in feces were included in the study. Hemogram
and blood gases were measured at the beginning of the treatment and
after the treatment. A single dose of 6 mg/kg body weight of gamithromycin
was administered subcutaneously. Drug efficacy was assessed by evaluating
the existence of diarrhea, oocyst shedding and body condition from day 1 to 5.<p>
<b>Results: </b>On 5<sup>th</sup> day, the medicated 6 calves had no oocysts, and number of
oocysts in feces had been decreased in 11 calves on 5th day. Statistically significant
difference (p<0.05) was observed in the blood values at the beginning of
the treatment and after the treatment.<p>
<b>Conclusion: </b>It has been determined that based on both clinical improvement
and decrease in oocyst count in feces, gamithromycin was found to have moderate
effect in the treatment of cryptosporidiosis in naturally infected neonatal
calves. |
| format | Article |
| id | doaj-art-3009ce398838426aa0bd87245a243926 |
| institution | Kabale University |
| issn | 1309-6958 2146-1953 |
| language | English |
| publishDate | 2021-03-01 |
| publisher | Selcuk University Press |
| record_format | Article |
| series | Eurasian Journal of Veterinary Sciences |
| spelling | doaj-art-3009ce398838426aa0bd87245a2439262025-01-03T01:36:18ZengSelcuk University PressEurasian Journal of Veterinary Sciences1309-69582146-19532021-03-0137149541346Evaluation of clinical efficacy of gamithromycin in the treatment of naturally infected neonatal calves with cryptosporidiosisMahmut Ok0Ferda Sevinç1Merve İder2Onur Ceylan3Alper Ertürk4Ceylan Ceylan5Murat Kaan Durgut6Selcuk University, Veterinary Faculty, Department of Internal Medicine, Konya, TurkeySelcuk University, Veterinary Faculty, Department of Parasitology, Konya, TurkeySelcuk University, Veterinary Faculty, Department of Internal Medicine, Konya, TurkeySelcuk University, Veterinary Faculty, Department of Parasitology, Konya, TurkeyMustafa Kemal University, Veterinary Faculty, Department of Internal Medicine, Hatay, TurkeySelcuk University, Veterinary Faculty, Department of Parasitology, Konya, TurkeySelcuk University, Veterinary Faculty, Department of Internal Medicine, Konya, Turkey<b>Aim: </b>The purpose of this study was to investigate the clinical efficacy of gamithromycin in the treatment of naturally infected neonatal calves with cryptosporidiosis.<p> <b>Materials and Methods: </b>5-20 days old 20 diarrheic neonatal calves were used as material in this study. Diagnosis of cryptosporidiosis was made by microscopic examination and ELISA test. Calves shedding Cryptosporidium oocysts between 4 x 10<sup>4</sup> and 15 x 10<sup>6</sup> per gram in feces were included in the study. Hemogram and blood gases were measured at the beginning of the treatment and after the treatment. A single dose of 6 mg/kg body weight of gamithromycin was administered subcutaneously. Drug efficacy was assessed by evaluating the existence of diarrhea, oocyst shedding and body condition from day 1 to 5.<p> <b>Results: </b>On 5<sup>th</sup> day, the medicated 6 calves had no oocysts, and number of oocysts in feces had been decreased in 11 calves on 5th day. Statistically significant difference (p<0.05) was observed in the blood values at the beginning of the treatment and after the treatment.<p> <b>Conclusion: </b>It has been determined that based on both clinical improvement and decrease in oocyst count in feces, gamithromycin was found to have moderate effect in the treatment of cryptosporidiosis in naturally infected neonatal calves.http://eurasianjvetsci.org/pdf.php3?id=1346calfcryptosporidiosistreatmentgamithromycin |
| spellingShingle | Mahmut Ok Ferda Sevinç Merve İder Onur Ceylan Alper Ertürk Ceylan Ceylan Murat Kaan Durgut Evaluation of clinical efficacy of gamithromycin in the treatment of naturally infected neonatal calves with cryptosporidiosis Eurasian Journal of Veterinary Sciences calf cryptosporidiosis treatment gamithromycin |
| title | Evaluation of clinical efficacy of gamithromycin in the treatment of naturally infected neonatal calves with cryptosporidiosis |
| title_full | Evaluation of clinical efficacy of gamithromycin in the treatment of naturally infected neonatal calves with cryptosporidiosis |
| title_fullStr | Evaluation of clinical efficacy of gamithromycin in the treatment of naturally infected neonatal calves with cryptosporidiosis |
| title_full_unstemmed | Evaluation of clinical efficacy of gamithromycin in the treatment of naturally infected neonatal calves with cryptosporidiosis |
| title_short | Evaluation of clinical efficacy of gamithromycin in the treatment of naturally infected neonatal calves with cryptosporidiosis |
| title_sort | evaluation of clinical efficacy of gamithromycin in the treatment of naturally infected neonatal calves with cryptosporidiosis |
| topic | calf cryptosporidiosis treatment gamithromycin |
| url | http://eurasianjvetsci.org/pdf.php3?id=1346 |
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