The efficacy and duration of treatment with propranolol in children with cyclic vomiting syndrome in southern Iran
Introduction : Cyclic vomiting syndrome is a functional disorder characterised by repeated episodes of nausea and vomiting with symptom-free intervals between the attacks. Cyclic vomiting syndrome is a migraine equivalent; therefore, anti-migraine medications are effective for cyclic vomiting syndro...
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| Language: | English |
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Termedia Publishing House
2017-12-01
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| Series: | Gastroenterology Review |
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| Online Access: | https://www.termedia.pl/The-efficacy-and-duration-of-treatment-with-propranolol-in-children-with-cyclic-vomiting-syndrome-in-southern-Iran,41,31247,1,1.html |
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| author | Mahmoud Haghighat Hajar Memari Naser Honar Seyed Mohsen Dehghani Mohammad-Hadi Imanieh Seyed-Javad Injoo Hazhir Javaherizadeh |
| author_facet | Mahmoud Haghighat Hajar Memari Naser Honar Seyed Mohsen Dehghani Mohammad-Hadi Imanieh Seyed-Javad Injoo Hazhir Javaherizadeh |
| author_sort | Mahmoud Haghighat |
| collection | DOAJ |
| description | Introduction : Cyclic vomiting syndrome is a functional disorder characterised by repeated episodes of nausea and vomiting with symptom-free intervals between the attacks. Cyclic vomiting syndrome is a migraine equivalent; therefore, anti-migraine medications are effective for cyclic vomiting syndrome prophylaxis, but duration of treatment is not clear.
Aim : To determine the efficacy and duration of drug therapy in cyclic vomiting syndrome.
Material and methods : This study was conducted on 206 cases of cyclic vomiting syndrome, who were treated with propranolol as prophylaxis. After they were symptom-free for at least 9 months, propranolol was tapered and discontinued and then they were followed for at least 6 months after drug withdrawal for evaluation of recurrence.
Results : The study subjects included 127 boys and 79 girls. The mean age of symptom onset was 3.4 years (range: 3 months to 14.5 years) and the mean age at the time of diagnosis was 5.7 years (range: 8.4 months to 18 years). Among the 206 patients in whom propranolol was discontinued, only 16 (7.8%) subjects developed recurrence of symptoms in the 6-month follow-up period.
Conclusions : There is no need to continue prophylaxis of cyclic vomiting syndrome for a long time. It is also possible to make the duration of drug therapy shorter, which is useful for the convenience of the patients and prevention of drug side effects. |
| format | Article |
| id | doaj-art-2ff889dc32334e10852df683002d94e5 |
| institution | Kabale University |
| issn | 1895-5770 1897-4317 |
| language | English |
| publishDate | 2017-12-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Gastroenterology Review |
| spelling | doaj-art-2ff889dc32334e10852df683002d94e52025-01-10T14:06:14ZengTermedia Publishing HouseGastroenterology Review1895-57701897-43172017-12-0112429129510.5114/pg.2017.7210531247The efficacy and duration of treatment with propranolol in children with cyclic vomiting syndrome in southern IranMahmoud HaghighatHajar MemariNaser HonarSeyed Mohsen DehghaniMohammad-Hadi ImaniehSeyed-Javad InjooHazhir JavaherizadehIntroduction : Cyclic vomiting syndrome is a functional disorder characterised by repeated episodes of nausea and vomiting with symptom-free intervals between the attacks. Cyclic vomiting syndrome is a migraine equivalent; therefore, anti-migraine medications are effective for cyclic vomiting syndrome prophylaxis, but duration of treatment is not clear. Aim : To determine the efficacy and duration of drug therapy in cyclic vomiting syndrome. Material and methods : This study was conducted on 206 cases of cyclic vomiting syndrome, who were treated with propranolol as prophylaxis. After they were symptom-free for at least 9 months, propranolol was tapered and discontinued and then they were followed for at least 6 months after drug withdrawal for evaluation of recurrence. Results : The study subjects included 127 boys and 79 girls. The mean age of symptom onset was 3.4 years (range: 3 months to 14.5 years) and the mean age at the time of diagnosis was 5.7 years (range: 8.4 months to 18 years). Among the 206 patients in whom propranolol was discontinued, only 16 (7.8%) subjects developed recurrence of symptoms in the 6-month follow-up period. Conclusions : There is no need to continue prophylaxis of cyclic vomiting syndrome for a long time. It is also possible to make the duration of drug therapy shorter, which is useful for the convenience of the patients and prevention of drug side effects.https://www.termedia.pl/The-efficacy-and-duration-of-treatment-with-propranolol-in-children-with-cyclic-vomiting-syndrome-in-southern-Iran,41,31247,1,1.htmlcyclic vomiting syndrome children propranolol duration of therapy prevention |
| spellingShingle | Mahmoud Haghighat Hajar Memari Naser Honar Seyed Mohsen Dehghani Mohammad-Hadi Imanieh Seyed-Javad Injoo Hazhir Javaherizadeh The efficacy and duration of treatment with propranolol in children with cyclic vomiting syndrome in southern Iran Gastroenterology Review cyclic vomiting syndrome children propranolol duration of therapy prevention |
| title | The efficacy and duration of treatment with propranolol in children with cyclic vomiting syndrome in southern Iran |
| title_full | The efficacy and duration of treatment with propranolol in children with cyclic vomiting syndrome in southern Iran |
| title_fullStr | The efficacy and duration of treatment with propranolol in children with cyclic vomiting syndrome in southern Iran |
| title_full_unstemmed | The efficacy and duration of treatment with propranolol in children with cyclic vomiting syndrome in southern Iran |
| title_short | The efficacy and duration of treatment with propranolol in children with cyclic vomiting syndrome in southern Iran |
| title_sort | efficacy and duration of treatment with propranolol in children with cyclic vomiting syndrome in southern iran |
| topic | cyclic vomiting syndrome children propranolol duration of therapy prevention |
| url | https://www.termedia.pl/The-efficacy-and-duration-of-treatment-with-propranolol-in-children-with-cyclic-vomiting-syndrome-in-southern-Iran,41,31247,1,1.html |
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