New perspectives on DNA methylation modifications in ocular diseases
The methylation of DNA is a prevalent epigenetic modification that plays a crucial role in the pathological progression of ocular diseases. DNA methylation can regulate gene expression, thereby affecting cell function and signal transduction. Ophthalmic diseases are a kind of complex diseases, and t...
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| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2025-02-01
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| Series: | International Journal of Ophthalmology |
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| Online Access: | http://ies.ijo.cn/en_publish/2025/2/20250219.pdf |
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| author | Fei-Fei Zong Da-Dong Jia Guang-Kun Huang Meng Pan Hao Hu Shi-Yi Song Liang Xiao Ru-Weng Wang Liang Liang |
| author_facet | Fei-Fei Zong Da-Dong Jia Guang-Kun Huang Meng Pan Hao Hu Shi-Yi Song Liang Xiao Ru-Weng Wang Liang Liang |
| author_sort | Fei-Fei Zong |
| collection | DOAJ |
| description | The methylation of DNA is a prevalent epigenetic modification that plays a crucial role in the pathological progression of ocular diseases. DNA methylation can regulate gene expression, thereby affecting cell function and signal transduction. Ophthalmic diseases are a kind of complex diseases, and their pathogenesis involves many factors such as genetic, environmental and individual differences. In addition, inflammation, oxidative stress and lipid metabolism, which abnormal DNA methylation is closely related to, are also considered to be major factors in eye diseases. The current understanding of DNA methylation in eye diseases is becoming more complex and comprehensive. In addition to the simple suppression of gene expression by hypermethylation, factors such as hypomethylation or demethylation, DNA methylation in non-promoter regions, interactions with other epigenetic modifications, and dynamic changes in DNA methylation must also be considered. Interestingly, although some genes are at abnormal methylation levels, their expression is not significantly changed, which indirectly reflects the complexity of gene regulation. This review aims to summarize and compare some relevant studies, and provide with new ideas and methods for the prevention and treatment of different eye diseases, such as glaucoma, retinoblastoma, and diabetic retinopathy. |
| format | Article |
| id | doaj-art-2ff4d8116da84e3e9d5210f830764491 |
| institution | Kabale University |
| issn | 2222-3959 2227-4898 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | International Journal of Ophthalmology |
| spelling | doaj-art-2ff4d8116da84e3e9d5210f8307644912025-01-16T07:54:35ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982025-02-0118234035010.18240/ijo.2025.02.1920250219New perspectives on DNA methylation modifications in ocular diseasesFei-Fei Zong0Da-Dong Jia1Guang-Kun Huang2Meng Pan3Hao Hu4Shi-Yi Song5Liang Xiao6Ru-Weng Wang7Liang Liang8Liang Liang. The Second People's Hospital of China Three Gorges University, the Second People's Hospital of Yichang, Yichang 443000, Hubei Province, China. liangliang419519@163.comThe Second People's Hospital of China Three Gorges University, the Second People's Hospital of Yichang, Yichang 443000, Hubei Province, ChinaDepartment of Ophthalmology, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, ChinaShaanxi University of Chinese Medicine, Basic Medical College, Xianyang 712046, Shaanxi Province, ChinaThe Second People's Hospital of China Three Gorges University, the Second People's Hospital of Yichang, Yichang 443000, Hubei Province, ChinaThe Second People's Hospital of China Three Gorges University, the Second People's Hospital of Yichang, Yichang 443000, Hubei Province, ChinaDepartment of Pathology, Yichang Central People's Hospital, the First College of Clinical Medical Science, China Three Gorges University, Yichang 443003, Hubei Province, ChinaThe Second People's Hospital of China Three Gorges University, the Second People's Hospital of Yichang, Yichang 443000, Hubei Province, ChinaThe Second People's Hospital of China Three Gorges University, the Second People's Hospital of Yichang, Yichang 443000, Hubei Province, ChinaThe methylation of DNA is a prevalent epigenetic modification that plays a crucial role in the pathological progression of ocular diseases. DNA methylation can regulate gene expression, thereby affecting cell function and signal transduction. Ophthalmic diseases are a kind of complex diseases, and their pathogenesis involves many factors such as genetic, environmental and individual differences. In addition, inflammation, oxidative stress and lipid metabolism, which abnormal DNA methylation is closely related to, are also considered to be major factors in eye diseases. The current understanding of DNA methylation in eye diseases is becoming more complex and comprehensive. In addition to the simple suppression of gene expression by hypermethylation, factors such as hypomethylation or demethylation, DNA methylation in non-promoter regions, interactions with other epigenetic modifications, and dynamic changes in DNA methylation must also be considered. Interestingly, although some genes are at abnormal methylation levels, their expression is not significantly changed, which indirectly reflects the complexity of gene regulation. This review aims to summarize and compare some relevant studies, and provide with new ideas and methods for the prevention and treatment of different eye diseases, such as glaucoma, retinoblastoma, and diabetic retinopathy.http://ies.ijo.cn/en_publish/2025/2/20250219.pdfdna methylation modificationepigeneticglaucomaretinoblastomadiabetic retinopathymethylase inhibitors |
| spellingShingle | Fei-Fei Zong Da-Dong Jia Guang-Kun Huang Meng Pan Hao Hu Shi-Yi Song Liang Xiao Ru-Weng Wang Liang Liang New perspectives on DNA methylation modifications in ocular diseases International Journal of Ophthalmology dna methylation modification epigenetic glaucoma retinoblastoma diabetic retinopathy methylase inhibitors |
| title | New perspectives on DNA methylation modifications in ocular diseases |
| title_full | New perspectives on DNA methylation modifications in ocular diseases |
| title_fullStr | New perspectives on DNA methylation modifications in ocular diseases |
| title_full_unstemmed | New perspectives on DNA methylation modifications in ocular diseases |
| title_short | New perspectives on DNA methylation modifications in ocular diseases |
| title_sort | new perspectives on dna methylation modifications in ocular diseases |
| topic | dna methylation modification epigenetic glaucoma retinoblastoma diabetic retinopathy methylase inhibitors |
| url | http://ies.ijo.cn/en_publish/2025/2/20250219.pdf |
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