Genetic evidence for the liver-brain axis: lipid metabolism and neurodegenerative disease risk

Genetic evidence for the liver-brain axis: lipid metabolism and neurodegenerative disease risk

Abstract Background The liver‒brain axis is critical in neurodegenerative diseases (NDs), with lipid metabolism influencing neuroinflammation and microglial function. A systematic investigation of the genetic relationship between lipid metabolism abnormalities and ND, namely, Alzheimer's diseas...

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Bibliographic Details
Main Authors: Zeyu Wang, Zixiao Yin, Guangyong Sun, Dong Zhang, Jianguo Zhang
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Lipids in Health and Disease
Subjects:
Mendelian Randomization Analysis
Lipid Metabolism
Neurodegenerative Diseases
Causality
Genetic Variation
Online Access:https://doi.org/10.1186/s12944-025-02455-3
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