PPP1R2 stimulates protein phosphatase-1 through stabilisation of dynamic subunit interactions

Abstract Protein Ser/Thr phosphatase PP1 is always associated with one or two regulatory subunits or RIPPOs. One of the earliest evolved RIPPOs is PPP1R2, also known as Inhibitor-2. Since its discovery nearly 5 decades ago, PPP1R2 has been variously described as an inhibitor, activator or (metal) ch...

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Bibliographic Details
Main Authors: Sarah Lemaire, Mónica Ferreira, Zander Claes, Rita Derua, Madryn Lake, Gerd Van der Hoeven, Fabienne Withof, Xinyu Cao, Elora C. Greiner, Arminja N. Kettenbach, Aleyde Van Eynde, Mathieu Bollen
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54256-4
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