Microbial perspective of multidisciplinary collaborative weight management approach: Ruminococcus gnavus may serve as a key target for weight loss
Changes in the gut microbiota are associated with obesity and may influence weight loss. We are currently implementing a sustained multidisciplinary collaborative weight management (MCWM) approach to weight loss. We report significant improvements in participant health status after 6 months, along w...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2025-12-01
|
| Series: | Gut Microbes |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/19490976.2024.2442038 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841557075437551616 |
|---|---|
| author | Sijia Zhao Wenjun Wu Wenyan Song Qunyan Zhou Haiyan Cheng Shukun Deng Jianxin Zhao Hao Zhang Wei Chen Hongchao Wang |
| author_facet | Sijia Zhao Wenjun Wu Wenyan Song Qunyan Zhou Haiyan Cheng Shukun Deng Jianxin Zhao Hao Zhang Wei Chen Hongchao Wang |
| author_sort | Sijia Zhao |
| collection | DOAJ |
| description | Changes in the gut microbiota are associated with obesity and may influence weight loss. We are currently implementing a sustained multidisciplinary collaborative weight management (MCWM) approach to weight loss. We report significant improvements in participant health status after 6 months, along with alterations in the structure, interactions, and metabolic functions of the microbiota. We observed an enrichment of the gut symbiont Ruminococcus gnavus in obese subjects, which was significantly correlated with clinical indicators and contributed significantly to random forest (RF) classification, and revealed its correlation with bile acid metabolism. Experimental results indicate that R. gnavus impairs weight loss in diet-modified obese mice by altering the gut microbiota structure and influencing bile acid metabolism. The findings of this study highlight the significant role of the gut microbiota in obese patients and establishes a more substantial scientific foundation for the prevention and management of obesity. |
| format | Article |
| id | doaj-art-2fb2b3df423a44f5a9797ae7f767a03d |
| institution | Kabale University |
| issn | 1949-0976 1949-0984 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gut Microbes |
| spelling | doaj-art-2fb2b3df423a44f5a9797ae7f767a03d2025-01-06T20:15:22ZengTaylor & Francis GroupGut Microbes1949-09761949-09842025-12-0117110.1080/19490976.2024.2442038Microbial perspective of multidisciplinary collaborative weight management approach: Ruminococcus gnavus may serve as a key target for weight lossSijia Zhao0Wenjun Wu1Wenyan Song2Qunyan Zhou3Haiyan Cheng4Shukun Deng5Jianxin Zhao6Hao Zhang7Wei Chen8Hongchao Wang9State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, ChinaJinshan Branch of Shanghai Sixth People’s Hospital, Shanghai, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, ChinaThe Affiliated Wuxi People’s Hospital of Nanjing Medical University, Wuxi People’s Hospital, Wuxi Medical Center, Nanjing Medical UniversityThe Affiliated Wuxi People’s Hospital of Nanjing Medical University, Wuxi People’s Hospital, Wuxi Medical Center, Nanjing Medical UniversityThe Affiliated Wuxi People’s Hospital of Nanjing Medical University, Wuxi People’s Hospital, Wuxi Medical Center, Nanjing Medical UniversityState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, ChinaChanges in the gut microbiota are associated with obesity and may influence weight loss. We are currently implementing a sustained multidisciplinary collaborative weight management (MCWM) approach to weight loss. We report significant improvements in participant health status after 6 months, along with alterations in the structure, interactions, and metabolic functions of the microbiota. We observed an enrichment of the gut symbiont Ruminococcus gnavus in obese subjects, which was significantly correlated with clinical indicators and contributed significantly to random forest (RF) classification, and revealed its correlation with bile acid metabolism. Experimental results indicate that R. gnavus impairs weight loss in diet-modified obese mice by altering the gut microbiota structure and influencing bile acid metabolism. The findings of this study highlight the significant role of the gut microbiota in obese patients and establishes a more substantial scientific foundation for the prevention and management of obesity.https://www.tandfonline.com/doi/10.1080/19490976.2024.2442038Gut microbiotaobesebile acidRuminococcus gnavusmachine learning |
| spellingShingle | Sijia Zhao Wenjun Wu Wenyan Song Qunyan Zhou Haiyan Cheng Shukun Deng Jianxin Zhao Hao Zhang Wei Chen Hongchao Wang Microbial perspective of multidisciplinary collaborative weight management approach: Ruminococcus gnavus may serve as a key target for weight loss Gut Microbes Gut microbiota obese bile acid Ruminococcus gnavus machine learning |
| title | Microbial perspective of multidisciplinary collaborative weight management approach: Ruminococcus gnavus may serve as a key target for weight loss |
| title_full | Microbial perspective of multidisciplinary collaborative weight management approach: Ruminococcus gnavus may serve as a key target for weight loss |
| title_fullStr | Microbial perspective of multidisciplinary collaborative weight management approach: Ruminococcus gnavus may serve as a key target for weight loss |
| title_full_unstemmed | Microbial perspective of multidisciplinary collaborative weight management approach: Ruminococcus gnavus may serve as a key target for weight loss |
| title_short | Microbial perspective of multidisciplinary collaborative weight management approach: Ruminococcus gnavus may serve as a key target for weight loss |
| title_sort | microbial perspective of multidisciplinary collaborative weight management approach ruminococcus gnavus may serve as a key target for weight loss |
| topic | Gut microbiota obese bile acid Ruminococcus gnavus machine learning |
| url | https://www.tandfonline.com/doi/10.1080/19490976.2024.2442038 |
| work_keys_str_mv | AT sijiazhao microbialperspectiveofmultidisciplinarycollaborativeweightmanagementapproachruminococcusgnavusmayserveasakeytargetforweightloss AT wenjunwu microbialperspectiveofmultidisciplinarycollaborativeweightmanagementapproachruminococcusgnavusmayserveasakeytargetforweightloss AT wenyansong microbialperspectiveofmultidisciplinarycollaborativeweightmanagementapproachruminococcusgnavusmayserveasakeytargetforweightloss AT qunyanzhou microbialperspectiveofmultidisciplinarycollaborativeweightmanagementapproachruminococcusgnavusmayserveasakeytargetforweightloss AT haiyancheng microbialperspectiveofmultidisciplinarycollaborativeweightmanagementapproachruminococcusgnavusmayserveasakeytargetforweightloss AT shukundeng microbialperspectiveofmultidisciplinarycollaborativeweightmanagementapproachruminococcusgnavusmayserveasakeytargetforweightloss AT jianxinzhao microbialperspectiveofmultidisciplinarycollaborativeweightmanagementapproachruminococcusgnavusmayserveasakeytargetforweightloss AT haozhang microbialperspectiveofmultidisciplinarycollaborativeweightmanagementapproachruminococcusgnavusmayserveasakeytargetforweightloss AT weichen microbialperspectiveofmultidisciplinarycollaborativeweightmanagementapproachruminococcusgnavusmayserveasakeytargetforweightloss AT hongchaowang microbialperspectiveofmultidisciplinarycollaborativeweightmanagementapproachruminococcusgnavusmayserveasakeytargetforweightloss |