Effectiveness and safety of hydrogen inhalation therapy as an additional treatment for hypertension in real-world practice: a retrospective, observational study in China
AimTo evaluate the real-life effectiveness and safety of hydrogen inhalation (HI) therapy as an additional treatment in Chinese adults with hypertension.MethodsThis observational, retrospective clinical study included hypertensive patients receiving routine antihypertensives with or without HI initi...
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1391282/full |
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| author | Hongxiang Ji Hualin Sun Yinghui Zhang Ziyi Zhao Xin Gao Chunhe Wang Yang Yang Xiaodong Zhang Jianyong Gao Dequan Man Qian Yang Ying Yang Chengbin Yue Changjiang Chen Xiaoheng Ding Tongshang Ni Tongshang Ni |
| author_facet | Hongxiang Ji Hualin Sun Yinghui Zhang Ziyi Zhao Xin Gao Chunhe Wang Yang Yang Xiaodong Zhang Jianyong Gao Dequan Man Qian Yang Ying Yang Chengbin Yue Changjiang Chen Xiaoheng Ding Tongshang Ni Tongshang Ni |
| author_sort | Hongxiang Ji |
| collection | DOAJ |
| description | AimTo evaluate the real-life effectiveness and safety of hydrogen inhalation (HI) therapy as an additional treatment in Chinese adults with hypertension.MethodsThis observational, retrospective clinical study included hypertensive patients receiving routine antihypertensives with or without HI initiation from 2018 to 2023. Participants were assigned to the HI group or non-HI group (control group) after propensity score matching. The changes in mean systolic blood pressure (SBP) level during the 24-week follow-up period in different groups were examined primarily. The secondary outcome was the changes in diastolic blood pressure (DBP) and blood pressure (BP) control rate during the study. Several subgroup and sensitivity analyses were performed to confirm the robustness of our main findings. Adverse event (AE) was also assessed in patients of both groups.ResultsIn total, we selected 2,364 patients into the analysis. Both mean SBP and DBP levels significantly decreased in the HI group compared to control group at each follow-up visit with the between group difference of −4.63 mm Hg (95% CI, −6.51 to −2.74) at week 8, −6.69 mm Hg (95% CI, −8.54 to −4.85) at week 16, −7.81 mm Hg (95% CI, −9.57 to −6.04) at week 24 for SBP, and −1.83 mm Hg (95% CI, −3.21 to −0.45) at week 8, −2.57 mm Hg (95% CI, −3.97 to −1.17) at week 16, −2.89 mm Hg (95% CI, −4.24 to −1.54) at week 24 for DBP. Patients in the HI group were more likely to attain controlled BP at the follow-up period with odds ratio of 1.44 (95% CI, 1.21–1.72) at week 8, 1.90 (95% CI, 1.59–2.27) at week 16, and 2.24 (95% CI, 1.87–2.68) at the end. The trends of subgroup and sensitivity analyses were mostly consistent with the main analysis. The incidences of AEs were similar between the HI group and control group with all p-value >0.05.ConclusionThe HI therapy is related to significant amelioration in BP levels with acceptable safety profile in Chinese hypertensive adults after 24 weeks of treatment, building a clinical ground for further research to evaluate the antihypertensive effect of HI therapy. |
| format | Article |
| id | doaj-art-2faa1c71bc2e4e2cad5b0411fb9ef5be |
| institution | Kabale University |
| issn | 2297-055X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj-art-2faa1c71bc2e4e2cad5b0411fb9ef5be2024-11-12T06:15:23ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2024-11-011110.3389/fcvm.2024.13912821391282Effectiveness and safety of hydrogen inhalation therapy as an additional treatment for hypertension in real-world practice: a retrospective, observational study in ChinaHongxiang Ji0Hualin Sun1Yinghui Zhang2Ziyi Zhao3Xin Gao4Chunhe Wang5Yang Yang6Xiaodong Zhang7Jianyong Gao8Dequan Man9Qian Yang10Ying Yang11Chengbin Yue12Changjiang Chen13Xiaoheng Ding14Tongshang Ni15Tongshang Ni16The First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, ChinaGraduate School, Chengde Medical University, Chengde, Hebei, ChinaNursing Department, Qingzhou People's Hospital, Qingzhou, Shandong, ChinaDepartment of Hand and Foot, Microsurgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, ChinaThe First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, ChinaThe First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, ChinaSchool of Health Management, Hengxing University, Qingdao, Shandong, ChinaSchool of Health Management, Hengxing University, Qingdao, Shandong, ChinaSchool of Health Management, Hengxing University, Qingdao, Shandong, ChinaSchool of Health Management, Hengxing University, Qingdao, Shandong, ChinaSchool of Health Management, Hengxing University, Qingdao, Shandong, ChinaSchool of Health Management, Hengxing University, Qingdao, Shandong, ChinaSchool of Health Management, Hengxing University, Qingdao, Shandong, ChinaSchool of Health Management, Hengxing University, Qingdao, Shandong, ChinaDepartment of Hand and Foot, Microsurgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, ChinaSchool of Health Management, Hengxing University, Qingdao, Shandong, ChinaCenter of Integrated Traditional Chinese and Western Medicine, School of Basic Medicine, Qingdao University, Qingdao, Shandong, ChinaAimTo evaluate the real-life effectiveness and safety of hydrogen inhalation (HI) therapy as an additional treatment in Chinese adults with hypertension.MethodsThis observational, retrospective clinical study included hypertensive patients receiving routine antihypertensives with or without HI initiation from 2018 to 2023. Participants were assigned to the HI group or non-HI group (control group) after propensity score matching. The changes in mean systolic blood pressure (SBP) level during the 24-week follow-up period in different groups were examined primarily. The secondary outcome was the changes in diastolic blood pressure (DBP) and blood pressure (BP) control rate during the study. Several subgroup and sensitivity analyses were performed to confirm the robustness of our main findings. Adverse event (AE) was also assessed in patients of both groups.ResultsIn total, we selected 2,364 patients into the analysis. Both mean SBP and DBP levels significantly decreased in the HI group compared to control group at each follow-up visit with the between group difference of −4.63 mm Hg (95% CI, −6.51 to −2.74) at week 8, −6.69 mm Hg (95% CI, −8.54 to −4.85) at week 16, −7.81 mm Hg (95% CI, −9.57 to −6.04) at week 24 for SBP, and −1.83 mm Hg (95% CI, −3.21 to −0.45) at week 8, −2.57 mm Hg (95% CI, −3.97 to −1.17) at week 16, −2.89 mm Hg (95% CI, −4.24 to −1.54) at week 24 for DBP. Patients in the HI group were more likely to attain controlled BP at the follow-up period with odds ratio of 1.44 (95% CI, 1.21–1.72) at week 8, 1.90 (95% CI, 1.59–2.27) at week 16, and 2.24 (95% CI, 1.87–2.68) at the end. The trends of subgroup and sensitivity analyses were mostly consistent with the main analysis. The incidences of AEs were similar between the HI group and control group with all p-value >0.05.ConclusionThe HI therapy is related to significant amelioration in BP levels with acceptable safety profile in Chinese hypertensive adults after 24 weeks of treatment, building a clinical ground for further research to evaluate the antihypertensive effect of HI therapy.https://www.frontiersin.org/articles/10.3389/fcvm.2024.1391282/fullhypertensionobservational studyhydrogen inhalationblood pressurereal-world study |
| spellingShingle | Hongxiang Ji Hualin Sun Yinghui Zhang Ziyi Zhao Xin Gao Chunhe Wang Yang Yang Xiaodong Zhang Jianyong Gao Dequan Man Qian Yang Ying Yang Chengbin Yue Changjiang Chen Xiaoheng Ding Tongshang Ni Tongshang Ni Effectiveness and safety of hydrogen inhalation therapy as an additional treatment for hypertension in real-world practice: a retrospective, observational study in China Frontiers in Cardiovascular Medicine hypertension observational study hydrogen inhalation blood pressure real-world study |
| title | Effectiveness and safety of hydrogen inhalation therapy as an additional treatment for hypertension in real-world practice: a retrospective, observational study in China |
| title_full | Effectiveness and safety of hydrogen inhalation therapy as an additional treatment for hypertension in real-world practice: a retrospective, observational study in China |
| title_fullStr | Effectiveness and safety of hydrogen inhalation therapy as an additional treatment for hypertension in real-world practice: a retrospective, observational study in China |
| title_full_unstemmed | Effectiveness and safety of hydrogen inhalation therapy as an additional treatment for hypertension in real-world practice: a retrospective, observational study in China |
| title_short | Effectiveness and safety of hydrogen inhalation therapy as an additional treatment for hypertension in real-world practice: a retrospective, observational study in China |
| title_sort | effectiveness and safety of hydrogen inhalation therapy as an additional treatment for hypertension in real world practice a retrospective observational study in china |
| topic | hypertension observational study hydrogen inhalation blood pressure real-world study |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1391282/full |
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