A novel non-invasive murine model for rapidly testing drug activity via inhalation administration against Mycobacterium tuberculosis

A novel non-invasive murine model for rapidly testing drug activity via inhalation administration against Mycobacterium tuberculosis

The efficacy of many compounds against Mycobacterium tuberculosis is often limited when administered via conventional oral or injection routes due to suboptimal pharmacokinetic characteristics. Inhalation-based delivery methods have been investigated to achieve high local therapeutic doses in the lu...

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Bibliographic Details
Main Authors: Xirong Tian, Yamin Gao, Chunyu Li, Wanli Ma, Jingran Zhang, Yanan Ju, Jie Ding, Sanshan Zeng, H. M. Adnan Hameed, Htin Lin Aung, Nanshan Zhong, Gregory M. Cook, Jinxing Hu, Tianyu Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Pharmacology
Subjects:
inhalation administration
autoluminescence
tuberculosis
murine model
chemotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1400436/full
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