A comparative analysis of sequence composition in different lots of a phage display peptide library during amplification

A comparative analysis of sequence composition in different lots of a phage display peptide library during amplification

Abstract Background To develop efficient selection strategies and improve the discovery of promising ligands, it is highly desirable to analyze the sequence composition of naïve phage display libraries and monitor the evolution of their peptide content during successive rounds of amplification. In t...

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Bibliographic Details
Main Authors: Anders Wilgaard Sinkjaer, Ane Beth Sloth, Amanda Oester Andersen, Malte Jensen, Babak Bakhshinejad, Andreas Kjaer
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Virology Journal
Subjects:
Amplification
Bias
Compositional heterogeneity
Enrichment factor
Illumina sequencing
Motif discovery
Online Access:https://doi.org/10.1186/s12985-024-02600-x
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