Predicting molecular mechanisms of hereditary diseases by using their tissue‐selective manifestation

Predicting molecular mechanisms of hereditary diseases by using their tissue‐selective manifestation

Abstract How do aberrations in widely expressed genes lead to tissue‐selective hereditary diseases? Previous attempts to answer this question were limited to testing a few candidate mechanisms. To answer this question at a larger scale, we developed “Tissue Risk Assessment of Causality by Expression...

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Main Authors: Eyal Simonovsky, Moran Sharon, Maya Ziv, Omry Mauer, Idan Hekselman, Juman Jubran, Ekaterina Vinogradov, Chanan M Argov, Omer Basha, Lior Kerber, Yuval Yogev, Ayellet V Segrè, Hae Kyung Im, GTEx Consortium, Ohad Birk, Lior Rokach, Esti Yeger‐Lotem
Format: Article
Language:English
Published: Springer Nature 2023-05-01
Series:Molecular Systems Biology
Subjects:
data integration
genomic medicine
machine learning
omics
tissue selectivity
Online Access:https://doi.org/10.15252/msb.202211407
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https://doi.org/10.15252/msb.202211407

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