β-receptor blocker enhances anti-tumor immunity via inhibiting lactate-induced norepinephrine metabolism of macrophages during malignant pleural effusion

β-receptor blocker enhances anti-tumor immunity via inhibiting lactate-induced norepinephrine metabolism of macrophages during malignant pleural effusion

IntroductionMalignant pleural effusion (MPE) is associated with poor quality of life and mortality in patients with tumors. In clinical practice, we observed that patients with malignant pleural effusion (MPE) and concurrent heart disease exhibited a decrease in MPE volumes following treatment with...

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Main Authors: Ru Zhang, Weijia Wang, Aitian Li, Huishang Wang, Xiaoyan Liu, Feifei Fan, Ying Wang, Huanyu Zhang, Jingxia Chang, Yinyin Zhang, Hongmin Wang, Lijun Miao, Bo Huang, Li Yang, Yi Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
macrophage
tumor immunity
norepinephrine metabolism
lactate
β-receptor blocker
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1497468/full
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